Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa

Detalhes bibliográficos
Autor(a) principal: Conde, Sandro José Conde [UNESP]
Data de Publicação: 2012
Outros Autores: Luvizotto, Renata de Azevedo Melo [UNESP], Síbio, Maria Teresa [UNESP], Saraiva, Patrícia Pinto, Brentani, Maria Mitzi, Nogueira, Célia Regina [UNESP]
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302012000400004
http://hdl.handle.net/11449/226909
Resumo: Objective: The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC). Subjects and methods: 12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), thyroid-stimulating hormone (TSH), free thyroxine (T4L), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), before and after surgery, besides immunohistochemistry for estrogen (ER) and progesterone (PR) receptors. Results: Four patients with CaM showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for TPO-AB. All of them positive for ER and PR. TSH levels in breast cancer patients were not different from levels found in the control group (1.89 ± 1.56 vs. 2.86 ± 3.12 mIU/mL), but the levels of T4L in patients with CaM were statistically higher than those of the control group (1.83 ± 0.57 vs. 1.10 ± 0.20 ng/dL). Conclusion: These results reinforce the need for assessment of thyroid status in CaM patients, since in the absence of E2, changes in clinical HTs can act in E2-controlled processes. © ABE&M todos os direitos reservados.
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spelling Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausaThyroid hormone profile in breast cancer patients in postmenopauseBreast neoplasmsHyperthyroidismPostmenopauseThyroid hormonesObjective: The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC). Subjects and methods: 12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), thyroid-stimulating hormone (TSH), free thyroxine (T4L), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), before and after surgery, besides immunohistochemistry for estrogen (ER) and progesterone (PR) receptors. Results: Four patients with CaM showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for TPO-AB. All of them positive for ER and PR. TSH levels in breast cancer patients were not different from levels found in the control group (1.89 ± 1.56 vs. 2.86 ± 3.12 mIU/mL), but the levels of T4L in patients with CaM were statistically higher than those of the control group (1.83 ± 0.57 vs. 1.10 ± 0.20 ng/dL). Conclusion: These results reinforce the need for assessment of thyroid status in CaM patients, since in the absence of E2, changes in clinical HTs can act in E2-controlled processes. © ABE&M todos os direitos reservados.Departamento de Clínica Médica Universidade Estadual Paulista 'Júlio de Mesquista Filho'(Unesp), Botucatu, SPDepartamento de Odontologia Universidade Sagrado Coração (USC), Bauru, SPDepartamento de Radiologia Universidade de São Paulo (USP), São Paulo, SPDepartamento de Clínica Médica Universidade Estadual Paulista 'Júlio de Mesquista Filho'(Unesp), Botucatu, SPUniversidade Estadual Paulista (UNESP)Universidade Sagrado Coração (USC)Universidade de São Paulo (USP)Conde, Sandro José Conde [UNESP]Luvizotto, Renata de Azevedo Melo [UNESP]Síbio, Maria Teresa [UNESP]Saraiva, Patrícia PintoBrentani, Maria MitziNogueira, Célia Regina [UNESP]2022-04-29T04:22:51Z2022-04-29T04:22:51Z2012-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article238-243http://dx.doi.org/10.1590/S0004-27302012000400004Arquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 4, p. 238-243, 2012.0004-27301677-9487http://hdl.handle.net/11449/22690910.1590/S0004-273020120004000042-s2.0-84864048042Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporArquivos Brasileiros de Endocrinologia e Metabologiainfo:eu-repo/semantics/openAccess2024-08-14T17:22:15Zoai:repositorio.unesp.br:11449/226909Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
Thyroid hormone profile in breast cancer patients in postmenopause
title Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
spellingShingle Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
Conde, Sandro José Conde [UNESP]
Breast neoplasms
Hyperthyroidism
Postmenopause
Thyroid hormones
title_short Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
title_full Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
title_fullStr Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
title_full_unstemmed Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
title_sort Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
author Conde, Sandro José Conde [UNESP]
author_facet Conde, Sandro José Conde [UNESP]
Luvizotto, Renata de Azevedo Melo [UNESP]
Síbio, Maria Teresa [UNESP]
Saraiva, Patrícia Pinto
Brentani, Maria Mitzi
Nogueira, Célia Regina [UNESP]
author_role author
author2 Luvizotto, Renata de Azevedo Melo [UNESP]
Síbio, Maria Teresa [UNESP]
Saraiva, Patrícia Pinto
Brentani, Maria Mitzi
Nogueira, Célia Regina [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade Sagrado Coração (USC)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Conde, Sandro José Conde [UNESP]
Luvizotto, Renata de Azevedo Melo [UNESP]
Síbio, Maria Teresa [UNESP]
Saraiva, Patrícia Pinto
Brentani, Maria Mitzi
Nogueira, Célia Regina [UNESP]
dc.subject.por.fl_str_mv Breast neoplasms
Hyperthyroidism
Postmenopause
Thyroid hormones
topic Breast neoplasms
Hyperthyroidism
Postmenopause
Thyroid hormones
description Objective: The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC). Subjects and methods: 12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), thyroid-stimulating hormone (TSH), free thyroxine (T4L), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), before and after surgery, besides immunohistochemistry for estrogen (ER) and progesterone (PR) receptors. Results: Four patients with CaM showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for TPO-AB. All of them positive for ER and PR. TSH levels in breast cancer patients were not different from levels found in the control group (1.89 ± 1.56 vs. 2.86 ± 3.12 mIU/mL), but the levels of T4L in patients with CaM were statistically higher than those of the control group (1.83 ± 0.57 vs. 1.10 ± 0.20 ng/dL). Conclusion: These results reinforce the need for assessment of thyroid status in CaM patients, since in the absence of E2, changes in clinical HTs can act in E2-controlled processes. © ABE&M todos os direitos reservados.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
2022-04-29T04:22:51Z
2022-04-29T04:22:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302012000400004
Arquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 4, p. 238-243, 2012.
0004-2730
1677-9487
http://hdl.handle.net/11449/226909
10.1590/S0004-27302012000400004
2-s2.0-84864048042
url http://dx.doi.org/10.1590/S0004-27302012000400004
http://hdl.handle.net/11449/226909
identifier_str_mv Arquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 4, p. 238-243, 2012.
0004-2730
1677-9487
10.1590/S0004-27302012000400004
2-s2.0-84864048042
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Endocrinologia e Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 238-243
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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