Otosporin reduces pulp inflammatory reactions after dental bleaching of rat molars

• Autor(a) principal: Ferreira, Luciana Louzada [UNESP]
• Data de Publicação: 2020
• Outros Autores: Benetti, Francine [UNESP], Álamo, Larissa [UNESP], Bosisio, Ana Caroline [UNESP], de Proença, Ariane Santana [UNESP], Rahal, Vanessa [UNESP], Sipert, Carla Renata, Briso, André Luiz Fraga [UNESP], Cintra, Luciano Tavares Angelo [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.14436/2358-2545.10.1.054-061.oar; http://hdl.handle.net/11449/228925
• topic: Anti-Inflammatory Agents; Dental Pulp; Hydrogen Peroxide; Tooth Bleaching

Introduction: Patients undergoing dental bleaching relate to postoperative sensitivity, that is linked to hydrogen peroxide (H2O2) penetrating on the dental pulp. This study evaluated the anti-inflammatory effect of ibuprofen, Otosporin®, and curcumin gel on the pulp of the rats’ teeth after bleaching. Methods: Fifty rats were divided into CG: controlplacebo gel; BLE: bleached (35% H2O2, 30 minutes); BLE-I: bleached and ibuprofen oral administration (twice every 12 hours in 2 successive days); BLE-O: bleached followed by Otosporin® application in the molar surfaces (10 minutes); and BLE-C: bleaching session followed curcumin gel (10 minutes). After two days, the rats were killed for histological analysis. Statistical tests were performed (P<.05). Results: BLE, BLE-I, and BLE-C had severe inflammation or necrosis in the occlusal third of coronal pulp (P>.05); BLE-O had mild inflammation and was similar from CG (P>.05) and different from other groups (P<.05). In the middle third, BLE-O group had lower inflammatory infiltration and remained different from BLE group (P<.05); BLE, BLE-I, and BLE-C were similar (P>.05). In the cervical third, BLE, BLE-I, and BLE-C had a reduction of inflammation, without difference between bleached groups (P>.05). Conclusions: Otosporin® can reduce the inflammation in the pulp after dental bleaching; this result was not observed using ibuprofen or curcumin gel. Therefore, this study shows a new teeth bleaching posttreatment possibility using Otosporin®, which minimizes the inflammation generated to the pulp tissue by the bleaching gel. This could consequently minimize the postoperative sensitivity.