Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft

Detalhes bibliográficos
Autor(a) principal: Bosco, Alvaro Francisco [UNESP]
Data de Publicação: 2016
Outros Autores: Faleiros, Paula Lazilha [UNESP], Carmona, Luana Rodrigues [UNESP], Garcia, Valdir Gouveia [UNESP], Theodoro, Letícia Helena [UNESP], de Araujo, Nathália Januario [UNESP], Nagata, Maria José Hitomi [UNESP], de Almeida, Juliano Milanezi [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jphotobiol.2016.08.040
http://hdl.handle.net/11449/173460
Resumo: Objective To histomorphometrically analyze the effect of low-level laser therapy (LLLT) on bone formation process in surgically created critical-size defects (CSDs) treated with bovine bone graft (BBG) and its influence over particles' resorption of BBG. Methods A 10-mm diameter CSD was surgically created in the calvaria of 64 male rats, which were distributed into 4 experimental groups: the C group (control), only blood clot; the LLLT group, LLLT (GaAlAs, 660 nm) and blood clot; the BBG group, CSD filled with BBG; the BBG/LLLT group, LLLT and CSD filled with BBG. Animals were euthanized at either 30 or 60 days post-operation. A histological analysis was performed. Additionally, the percentage of newly formed bone area (NFBA) and remaining particles areas (RPA) of BBG were histometrically evaluated and data statistically analyzed. Results The LLLT (5.82 ± 2.05; 7.34 ± 1.01) group presented significantly greater NFBA when compared to the C group (1.61 ± 0.30; 5.59 ± 0.94) at 30 and 60 days post-operation (p < 0.05). The BBG/LLLT group (7.39 ± 1.45; 9.44 ± 2.36) presented significantly greater NFBA than the BBG group (3.85 ± 1.56; 8.02 ± 0.63) at 30 and 60 days postoperation (p < 0.05). There was no significant difference in the mean percentage of implanted material RPA between the BBG and the BBG/LLLT groups. Conclusions LLLT can improve bone formation process in CSD filled or not with BBG in rat calvaria, but it is not able to accelerate particles resorption of this material in the interior of bone defect.
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spelling Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graftBone graftingBone regenerationCalvariaLow-level laser therapyObjective To histomorphometrically analyze the effect of low-level laser therapy (LLLT) on bone formation process in surgically created critical-size defects (CSDs) treated with bovine bone graft (BBG) and its influence over particles' resorption of BBG. Methods A 10-mm diameter CSD was surgically created in the calvaria of 64 male rats, which were distributed into 4 experimental groups: the C group (control), only blood clot; the LLLT group, LLLT (GaAlAs, 660 nm) and blood clot; the BBG group, CSD filled with BBG; the BBG/LLLT group, LLLT and CSD filled with BBG. Animals were euthanized at either 30 or 60 days post-operation. A histological analysis was performed. Additionally, the percentage of newly formed bone area (NFBA) and remaining particles areas (RPA) of BBG were histometrically evaluated and data statistically analyzed. Results The LLLT (5.82 ± 2.05; 7.34 ± 1.01) group presented significantly greater NFBA when compared to the C group (1.61 ± 0.30; 5.59 ± 0.94) at 30 and 60 days post-operation (p < 0.05). The BBG/LLLT group (7.39 ± 1.45; 9.44 ± 2.36) presented significantly greater NFBA than the BBG group (3.85 ± 1.56; 8.02 ± 0.63) at 30 and 60 days postoperation (p < 0.05). There was no significant difference in the mean percentage of implanted material RPA between the BBG and the BBG/LLLT groups. Conclusions LLLT can improve bone formation process in CSD filled or not with BBG in rat calvaria, but it is not able to accelerate particles resorption of this material in the interior of bone defect.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ. Estadual Paulista - UNESP Division of Periodontics Department of Surgery and Integrated Clinic Dental School of Araçatuba, Rua José Bonifácio, n° 1193University Center of Educational Foundation of Barretos – UNIFEB Department of Periodontics Dental School of Barretos, Avenida Professor Roberto Frade Monte, n° 389Univ. Estadual Paulista - UNESP Division of Periodontics Department of Surgery and Integrated Clinic Dental School of Araçatuba, Rua José Bonifácio, n° 1193FAPESP: 07/05896-1Universidade Estadual Paulista (Unesp)Dental School of BarretosBosco, Alvaro Francisco [UNESP]Faleiros, Paula Lazilha [UNESP]Carmona, Luana Rodrigues [UNESP]Garcia, Valdir Gouveia [UNESP]Theodoro, Letícia Helena [UNESP]de Araujo, Nathália Januario [UNESP]Nagata, Maria José Hitomi [UNESP]de Almeida, Juliano Milanezi [UNESP]2018-12-11T17:05:36Z2018-12-11T17:05:36Z2016-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article303-310application/pdfhttp://dx.doi.org/10.1016/j.jphotobiol.2016.08.040Journal of Photochemistry and Photobiology B: Biology, v. 163, p. 303-310.1873-26821011-1344http://hdl.handle.net/11449/17346010.1016/j.jphotobiol.2016.08.0402-s2.0-849865928532-s2.0-84986592853.pdf47744471181273468399870097572073Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Photochemistry and Photobiology B: Biology0,698info:eu-repo/semantics/openAccess2024-09-19T13:30:01Zoai:repositorio.unesp.br:11449/173460Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T13:30:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
title Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
spellingShingle Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
Bosco, Alvaro Francisco [UNESP]
Bone grafting
Bone regeneration
Calvaria
Low-level laser therapy
title_short Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
title_full Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
title_fullStr Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
title_full_unstemmed Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
title_sort Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
author Bosco, Alvaro Francisco [UNESP]
author_facet Bosco, Alvaro Francisco [UNESP]
Faleiros, Paula Lazilha [UNESP]
Carmona, Luana Rodrigues [UNESP]
Garcia, Valdir Gouveia [UNESP]
Theodoro, Letícia Helena [UNESP]
de Araujo, Nathália Januario [UNESP]
Nagata, Maria José Hitomi [UNESP]
de Almeida, Juliano Milanezi [UNESP]
author_role author
author2 Faleiros, Paula Lazilha [UNESP]
Carmona, Luana Rodrigues [UNESP]
Garcia, Valdir Gouveia [UNESP]
Theodoro, Letícia Helena [UNESP]
de Araujo, Nathália Januario [UNESP]
Nagata, Maria José Hitomi [UNESP]
de Almeida, Juliano Milanezi [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Dental School of Barretos
dc.contributor.author.fl_str_mv Bosco, Alvaro Francisco [UNESP]
Faleiros, Paula Lazilha [UNESP]
Carmona, Luana Rodrigues [UNESP]
Garcia, Valdir Gouveia [UNESP]
Theodoro, Letícia Helena [UNESP]
de Araujo, Nathália Januario [UNESP]
Nagata, Maria José Hitomi [UNESP]
de Almeida, Juliano Milanezi [UNESP]
dc.subject.por.fl_str_mv Bone grafting
Bone regeneration
Calvaria
Low-level laser therapy
topic Bone grafting
Bone regeneration
Calvaria
Low-level laser therapy
description Objective To histomorphometrically analyze the effect of low-level laser therapy (LLLT) on bone formation process in surgically created critical-size defects (CSDs) treated with bovine bone graft (BBG) and its influence over particles' resorption of BBG. Methods A 10-mm diameter CSD was surgically created in the calvaria of 64 male rats, which were distributed into 4 experimental groups: the C group (control), only blood clot; the LLLT group, LLLT (GaAlAs, 660 nm) and blood clot; the BBG group, CSD filled with BBG; the BBG/LLLT group, LLLT and CSD filled with BBG. Animals were euthanized at either 30 or 60 days post-operation. A histological analysis was performed. Additionally, the percentage of newly formed bone area (NFBA) and remaining particles areas (RPA) of BBG were histometrically evaluated and data statistically analyzed. Results The LLLT (5.82 ± 2.05; 7.34 ± 1.01) group presented significantly greater NFBA when compared to the C group (1.61 ± 0.30; 5.59 ± 0.94) at 30 and 60 days post-operation (p < 0.05). The BBG/LLLT group (7.39 ± 1.45; 9.44 ± 2.36) presented significantly greater NFBA than the BBG group (3.85 ± 1.56; 8.02 ± 0.63) at 30 and 60 days postoperation (p < 0.05). There was no significant difference in the mean percentage of implanted material RPA between the BBG and the BBG/LLLT groups. Conclusions LLLT can improve bone formation process in CSD filled or not with BBG in rat calvaria, but it is not able to accelerate particles resorption of this material in the interior of bone defect.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-01
2018-12-11T17:05:36Z
2018-12-11T17:05:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jphotobiol.2016.08.040
Journal of Photochemistry and Photobiology B: Biology, v. 163, p. 303-310.
1873-2682
1011-1344
http://hdl.handle.net/11449/173460
10.1016/j.jphotobiol.2016.08.040
2-s2.0-84986592853
2-s2.0-84986592853.pdf
4774447118127346
8399870097572073
url http://dx.doi.org/10.1016/j.jphotobiol.2016.08.040
http://hdl.handle.net/11449/173460
identifier_str_mv Journal of Photochemistry and Photobiology B: Biology, v. 163, p. 303-310.
1873-2682
1011-1344
10.1016/j.jphotobiol.2016.08.040
2-s2.0-84986592853
2-s2.0-84986592853.pdf
4774447118127346
8399870097572073
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Photochemistry and Photobiology B: Biology
0,698
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 303-310
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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