Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jphotobiol.2016.08.040 http://hdl.handle.net/11449/173460 |
Resumo: | Objective To histomorphometrically analyze the effect of low-level laser therapy (LLLT) on bone formation process in surgically created critical-size defects (CSDs) treated with bovine bone graft (BBG) and its influence over particles' resorption of BBG. Methods A 10-mm diameter CSD was surgically created in the calvaria of 64 male rats, which were distributed into 4 experimental groups: the C group (control), only blood clot; the LLLT group, LLLT (GaAlAs, 660 nm) and blood clot; the BBG group, CSD filled with BBG; the BBG/LLLT group, LLLT and CSD filled with BBG. Animals were euthanized at either 30 or 60 days post-operation. A histological analysis was performed. Additionally, the percentage of newly formed bone area (NFBA) and remaining particles areas (RPA) of BBG were histometrically evaluated and data statistically analyzed. Results The LLLT (5.82 ± 2.05; 7.34 ± 1.01) group presented significantly greater NFBA when compared to the C group (1.61 ± 0.30; 5.59 ± 0.94) at 30 and 60 days post-operation (p < 0.05). The BBG/LLLT group (7.39 ± 1.45; 9.44 ± 2.36) presented significantly greater NFBA than the BBG group (3.85 ± 1.56; 8.02 ± 0.63) at 30 and 60 days postoperation (p < 0.05). There was no significant difference in the mean percentage of implanted material RPA between the BBG and the BBG/LLLT groups. Conclusions LLLT can improve bone formation process in CSD filled or not with BBG in rat calvaria, but it is not able to accelerate particles resorption of this material in the interior of bone defect. |
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Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graftBone graftingBone regenerationCalvariaLow-level laser therapyObjective To histomorphometrically analyze the effect of low-level laser therapy (LLLT) on bone formation process in surgically created critical-size defects (CSDs) treated with bovine bone graft (BBG) and its influence over particles' resorption of BBG. Methods A 10-mm diameter CSD was surgically created in the calvaria of 64 male rats, which were distributed into 4 experimental groups: the C group (control), only blood clot; the LLLT group, LLLT (GaAlAs, 660 nm) and blood clot; the BBG group, CSD filled with BBG; the BBG/LLLT group, LLLT and CSD filled with BBG. Animals were euthanized at either 30 or 60 days post-operation. A histological analysis was performed. Additionally, the percentage of newly formed bone area (NFBA) and remaining particles areas (RPA) of BBG were histometrically evaluated and data statistically analyzed. Results The LLLT (5.82 ± 2.05; 7.34 ± 1.01) group presented significantly greater NFBA when compared to the C group (1.61 ± 0.30; 5.59 ± 0.94) at 30 and 60 days post-operation (p < 0.05). The BBG/LLLT group (7.39 ± 1.45; 9.44 ± 2.36) presented significantly greater NFBA than the BBG group (3.85 ± 1.56; 8.02 ± 0.63) at 30 and 60 days postoperation (p < 0.05). There was no significant difference in the mean percentage of implanted material RPA between the BBG and the BBG/LLLT groups. Conclusions LLLT can improve bone formation process in CSD filled or not with BBG in rat calvaria, but it is not able to accelerate particles resorption of this material in the interior of bone defect.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ. Estadual Paulista - UNESP Division of Periodontics Department of Surgery and Integrated Clinic Dental School of Araçatuba, Rua José Bonifácio, n° 1193University Center of Educational Foundation of Barretos – UNIFEB Department of Periodontics Dental School of Barretos, Avenida Professor Roberto Frade Monte, n° 389Univ. Estadual Paulista - UNESP Division of Periodontics Department of Surgery and Integrated Clinic Dental School of Araçatuba, Rua José Bonifácio, n° 1193FAPESP: 07/05896-1Universidade Estadual Paulista (Unesp)Dental School of BarretosBosco, Alvaro Francisco [UNESP]Faleiros, Paula Lazilha [UNESP]Carmona, Luana Rodrigues [UNESP]Garcia, Valdir Gouveia [UNESP]Theodoro, Letícia Helena [UNESP]de Araujo, Nathália Januario [UNESP]Nagata, Maria José Hitomi [UNESP]de Almeida, Juliano Milanezi [UNESP]2018-12-11T17:05:36Z2018-12-11T17:05:36Z2016-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article303-310application/pdfhttp://dx.doi.org/10.1016/j.jphotobiol.2016.08.040Journal of Photochemistry and Photobiology B: Biology, v. 163, p. 303-310.1873-26821011-1344http://hdl.handle.net/11449/17346010.1016/j.jphotobiol.2016.08.0402-s2.0-849865928532-s2.0-84986592853.pdf47744471181273468399870097572073Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Photochemistry and Photobiology B: Biology0,698info:eu-repo/semantics/openAccess2024-09-19T13:30:01Zoai:repositorio.unesp.br:11449/173460Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T13:30:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
title |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
spellingShingle |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft Bosco, Alvaro Francisco [UNESP] Bone grafting Bone regeneration Calvaria Low-level laser therapy |
title_short |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
title_full |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
title_fullStr |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
title_full_unstemmed |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
title_sort |
Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft |
author |
Bosco, Alvaro Francisco [UNESP] |
author_facet |
Bosco, Alvaro Francisco [UNESP] Faleiros, Paula Lazilha [UNESP] Carmona, Luana Rodrigues [UNESP] Garcia, Valdir Gouveia [UNESP] Theodoro, Letícia Helena [UNESP] de Araujo, Nathália Januario [UNESP] Nagata, Maria José Hitomi [UNESP] de Almeida, Juliano Milanezi [UNESP] |
author_role |
author |
author2 |
Faleiros, Paula Lazilha [UNESP] Carmona, Luana Rodrigues [UNESP] Garcia, Valdir Gouveia [UNESP] Theodoro, Letícia Helena [UNESP] de Araujo, Nathália Januario [UNESP] Nagata, Maria José Hitomi [UNESP] de Almeida, Juliano Milanezi [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Dental School of Barretos |
dc.contributor.author.fl_str_mv |
Bosco, Alvaro Francisco [UNESP] Faleiros, Paula Lazilha [UNESP] Carmona, Luana Rodrigues [UNESP] Garcia, Valdir Gouveia [UNESP] Theodoro, Letícia Helena [UNESP] de Araujo, Nathália Januario [UNESP] Nagata, Maria José Hitomi [UNESP] de Almeida, Juliano Milanezi [UNESP] |
dc.subject.por.fl_str_mv |
Bone grafting Bone regeneration Calvaria Low-level laser therapy |
topic |
Bone grafting Bone regeneration Calvaria Low-level laser therapy |
description |
Objective To histomorphometrically analyze the effect of low-level laser therapy (LLLT) on bone formation process in surgically created critical-size defects (CSDs) treated with bovine bone graft (BBG) and its influence over particles' resorption of BBG. Methods A 10-mm diameter CSD was surgically created in the calvaria of 64 male rats, which were distributed into 4 experimental groups: the C group (control), only blood clot; the LLLT group, LLLT (GaAlAs, 660 nm) and blood clot; the BBG group, CSD filled with BBG; the BBG/LLLT group, LLLT and CSD filled with BBG. Animals were euthanized at either 30 or 60 days post-operation. A histological analysis was performed. Additionally, the percentage of newly formed bone area (NFBA) and remaining particles areas (RPA) of BBG were histometrically evaluated and data statistically analyzed. Results The LLLT (5.82 ± 2.05; 7.34 ± 1.01) group presented significantly greater NFBA when compared to the C group (1.61 ± 0.30; 5.59 ± 0.94) at 30 and 60 days post-operation (p < 0.05). The BBG/LLLT group (7.39 ± 1.45; 9.44 ± 2.36) presented significantly greater NFBA than the BBG group (3.85 ± 1.56; 8.02 ± 0.63) at 30 and 60 days postoperation (p < 0.05). There was no significant difference in the mean percentage of implanted material RPA between the BBG and the BBG/LLLT groups. Conclusions LLLT can improve bone formation process in CSD filled or not with BBG in rat calvaria, but it is not able to accelerate particles resorption of this material in the interior of bone defect. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 2018-12-11T17:05:36Z 2018-12-11T17:05:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jphotobiol.2016.08.040 Journal of Photochemistry and Photobiology B: Biology, v. 163, p. 303-310. 1873-2682 1011-1344 http://hdl.handle.net/11449/173460 10.1016/j.jphotobiol.2016.08.040 2-s2.0-84986592853 2-s2.0-84986592853.pdf 4774447118127346 8399870097572073 |
url |
http://dx.doi.org/10.1016/j.jphotobiol.2016.08.040 http://hdl.handle.net/11449/173460 |
identifier_str_mv |
Journal of Photochemistry and Photobiology B: Biology, v. 163, p. 303-310. 1873-2682 1011-1344 10.1016/j.jphotobiol.2016.08.040 2-s2.0-84986592853 2-s2.0-84986592853.pdf 4774447118127346 8399870097572073 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Photochemistry and Photobiology B: Biology 0,698 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
303-310 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546387579600896 |