Efeito da aPDT na osseointegração de implantes em alvéolos contaminados

• Autor(a) principal: Theodoro, Letícia Helena [UNESP]
• Data de Publicação: 2012
• Outros Autores: Almeida, Juliano Milanezi de [UNESP], Gualberto Júnior, Erivan Clementino [UNESP], Fernandes, Leandro Araujo, Silveira, Luis Geraldo, Longo, Mariéllen [UNESP], Marcantonio Júnior, Elcio [UNESP], Garcia, Valdir Gouveia [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://revodontolunesp.com.br/article/51ae4aa81ef1faca3d00386c; http://hdl.handle.net/11449/125440
• topic: Dental implantation; Lasers; Periodontitis; Photochemotherapy; Rats; Implante dentário; Lasers; Periodontite; Fotoquimioterapia; Ratos

Objective: The aim of this study is to evaluate by histometric and immunohistochemistry analysis the effects of antimicrobial photodynamic therapy (aPDT) in alveolar prior to placement of mini-implants in animals with or without induced periodontal disease. Material and method: Thirty-two rats were used. Periodontal disease (PD) was induced by ligature in the lower left first molar. After 7 days of PD evolution, it was performed removal of the ligature and extraction of the left lower first molars in all animals. Thus, animals were divided into 2 groups (n=16) according to the treatments in the dental alveolus before immediate implant installation: MD (control) : mechanical debridement (MD), irrigation with 1 ml of saline solution followed by implant installation; aPDT- MD, irrigation with 1 ml of Toluidine Blue-O and low intensity laser (LLLT) and implant installation. Eight animals from each group were euthanized at 15 and 30 days after the installation of mini-implants. Specimens were processed for histologic, immunohistochemical and histometric analysis. The histometric data were processed for statistical analysis (Kruskall-Wallis and Dunn test; p <0.05). Result: In treatment analysis, results indicated that there was a greater BIC in implants installed in uncontaminated alveolus treated with a PDT ( p<0,05) and greater imuno-reactivity to OPG in bone issue treated with aPDT. Conclusion: The aPDT proved to be effective in bone loss control in no contaminated area and it has increased the bone loss and metabolic activity in alveolus irradiated prior to implant installation.