Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.amjoto.2019.102321 http://hdl.handle.net/11449/198226 |
Resumo: | Objective: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale. Materials and methods: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: ≥20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test. Results: The ARRP showed significantly higher quantities of CD3+, CD8+ and MUM1+ cells (p < .05) than the JRRP samples. The presence of CD15+ cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01). Conclusion: There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity. |
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Relationship between inflammation and the severity of Recurrent Respiratory PapillomatosisHuman papillomavirusInflammatory cellsLaryngeal papillomatosisSquamous cell papillomatosisObjective: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale. Materials and methods: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: ≥20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test. Results: The ARRP showed significantly higher quantities of CD3+, CD8+ and MUM1+ cells (p < .05) than the JRRP samples. The presence of CD15+ cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01). Conclusion: There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University - UNESPDepartment of Pathology Ribeirão Preto School of Medicine University of São PauloPathology Department Hospital Herrera-LlerandiOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry School of Dentistry of Ribeirão Preto University of São PauloDepartment of Pathology and Legal Medicine Ribeirão Preto School of Medicine University of São PauloDepartment of Otorhinolaryngology and Head and Neck Surgery São Paulo Federal UniversityDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University - UNESPFAPESP: 16/24019-0Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Hospital Herrera-LlerandiSão Paulo Federal UniversityEl Achkar, Vivian Narana Ribeiro [UNESP]Duarte, AndressaCarlos, RománLeón, Jorge EsquicheRibeiro-Silva, AlfredoPignatari, Shirley Shizue NagataKaminagakura, Estela [UNESP]2020-12-12T01:07:01Z2020-12-12T01:07:01Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.amjoto.2019.102321American Journal of Otolaryngology - Head and Neck Medicine and Surgery, v. 41, n. 2, 2020.1532-818X0196-0709http://hdl.handle.net/11449/19822610.1016/j.amjoto.2019.1023212-s2.0-85075903383Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgeryinfo:eu-repo/semantics/openAccess2021-10-23T10:02:23Zoai:repositorio.unesp.br:11449/198226Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:01:50.655569Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis |
title |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis |
spellingShingle |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis El Achkar, Vivian Narana Ribeiro [UNESP] Human papillomavirus Inflammatory cells Laryngeal papillomatosis Squamous cell papillomatosis |
title_short |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis |
title_full |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis |
title_fullStr |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis |
title_full_unstemmed |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis |
title_sort |
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis |
author |
El Achkar, Vivian Narana Ribeiro [UNESP] |
author_facet |
El Achkar, Vivian Narana Ribeiro [UNESP] Duarte, Andressa Carlos, Román León, Jorge Esquiche Ribeiro-Silva, Alfredo Pignatari, Shirley Shizue Nagata Kaminagakura, Estela [UNESP] |
author_role |
author |
author2 |
Duarte, Andressa Carlos, Román León, Jorge Esquiche Ribeiro-Silva, Alfredo Pignatari, Shirley Shizue Nagata Kaminagakura, Estela [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Hospital Herrera-Llerandi São Paulo Federal University |
dc.contributor.author.fl_str_mv |
El Achkar, Vivian Narana Ribeiro [UNESP] Duarte, Andressa Carlos, Román León, Jorge Esquiche Ribeiro-Silva, Alfredo Pignatari, Shirley Shizue Nagata Kaminagakura, Estela [UNESP] |
dc.subject.por.fl_str_mv |
Human papillomavirus Inflammatory cells Laryngeal papillomatosis Squamous cell papillomatosis |
topic |
Human papillomavirus Inflammatory cells Laryngeal papillomatosis Squamous cell papillomatosis |
description |
Objective: To characterize inflammatory cells in Recurrent Respiratory Papillomatosis (RRP) and to correlate it with severity using the Derkay laryngoscopic scale. Materials and methods: The data and biopsies from 36 patients with Juvenile (JRRP) and 56 patients with Adult (ARRP) were collected and analyzed under light microscopy. The patients were separated into groups according to the Derkay index: ≥20 for the most severe and < 20 for the less severe cases. Immunohistochemical analysis using CD3, CD4, CD8, CD15, CD20, CD68, FoxP3 and MUM-1 antibodies was performed, and the inflammatory cells were quantified. All the clinicopathological characteristics and the results of the immunohistochemical analysis were compared among the groups proposed using the Chi-Square test and correlated through the Spearman correlation test. Results: The ARRP showed significantly higher quantities of CD3+, CD8+ and MUM1+ cells (p < .05) than the JRRP samples. The presence of CD15+ cells showed positive correlation with the Derkay index (p < .05), while the MUM-1+ cells showed an inverse correlation (p = .01). Conclusion: There are differences between the inflammatory cells population in the juvenile and adult groups and it can be related to disease severity. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:07:01Z 2020-12-12T01:07:01Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.amjoto.2019.102321 American Journal of Otolaryngology - Head and Neck Medicine and Surgery, v. 41, n. 2, 2020. 1532-818X 0196-0709 http://hdl.handle.net/11449/198226 10.1016/j.amjoto.2019.102321 2-s2.0-85075903383 |
url |
http://dx.doi.org/10.1016/j.amjoto.2019.102321 http://hdl.handle.net/11449/198226 |
identifier_str_mv |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery, v. 41, n. 2, 2020. 1532-818X 0196-0709 10.1016/j.amjoto.2019.102321 2-s2.0-85075903383 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129150858297344 |