Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/10837450.2019.1682608 http://hdl.handle.net/11449/199676 |
Resumo: | Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18–30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery. |
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Repositório Institucional da UNESP |
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spelling |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug deliverycontrolled releasemechanical propertiesmucoadhesionSolvent casting methodswelling abilitywater vapor permeabilityFilms of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18–30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery.Department of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESPFaculty for Pharmaceutical Engineering University of Albstadt-SigmaringenDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESPUniversidade Estadual Paulista (Unesp)University of Albstadt-SigmaringenPrezotti, Fabíola Garavello [UNESP]Siedle, IzabelBoni, Fernanda Isadora [UNESP]Chorilli, Marlus [UNESP]Müller, IngridCury, Beatriz Stringhetti Ferreira [UNESP]2020-12-12T01:46:19Z2020-12-12T01:46:19Z2020-02-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article159-167http://dx.doi.org/10.1080/10837450.2019.1682608Pharmaceutical Development and Technology, v. 25, n. 2, p. 159-167, 2020.1097-98671083-7450http://hdl.handle.net/11449/19967610.1080/10837450.2019.16826082-s2.0-85075229584Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceutical Development and Technologyinfo:eu-repo/semantics/openAccess2024-06-24T13:45:29Zoai:repositorio.unesp.br:11449/199676Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:20:51.678404Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery |
title |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery |
spellingShingle |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery Prezotti, Fabíola Garavello [UNESP] controlled release mechanical properties mucoadhesion Solvent casting method swelling ability water vapor permeability |
title_short |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery |
title_full |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery |
title_fullStr |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery |
title_full_unstemmed |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery |
title_sort |
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery |
author |
Prezotti, Fabíola Garavello [UNESP] |
author_facet |
Prezotti, Fabíola Garavello [UNESP] Siedle, Izabel Boni, Fernanda Isadora [UNESP] Chorilli, Marlus [UNESP] Müller, Ingrid Cury, Beatriz Stringhetti Ferreira [UNESP] |
author_role |
author |
author2 |
Siedle, Izabel Boni, Fernanda Isadora [UNESP] Chorilli, Marlus [UNESP] Müller, Ingrid Cury, Beatriz Stringhetti Ferreira [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Albstadt-Sigmaringen |
dc.contributor.author.fl_str_mv |
Prezotti, Fabíola Garavello [UNESP] Siedle, Izabel Boni, Fernanda Isadora [UNESP] Chorilli, Marlus [UNESP] Müller, Ingrid Cury, Beatriz Stringhetti Ferreira [UNESP] |
dc.subject.por.fl_str_mv |
controlled release mechanical properties mucoadhesion Solvent casting method swelling ability water vapor permeability |
topic |
controlled release mechanical properties mucoadhesion Solvent casting method swelling ability water vapor permeability |
description |
Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18–30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:46:19Z 2020-12-12T01:46:19Z 2020-02-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/10837450.2019.1682608 Pharmaceutical Development and Technology, v. 25, n. 2, p. 159-167, 2020. 1097-9867 1083-7450 http://hdl.handle.net/11449/199676 10.1080/10837450.2019.1682608 2-s2.0-85075229584 |
url |
http://dx.doi.org/10.1080/10837450.2019.1682608 http://hdl.handle.net/11449/199676 |
identifier_str_mv |
Pharmaceutical Development and Technology, v. 25, n. 2, p. 159-167, 2020. 1097-9867 1083-7450 10.1080/10837450.2019.1682608 2-s2.0-85075229584 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceutical Development and Technology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
159-167 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128636387065856 |