Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease

Detalhes bibliográficos
Autor(a) principal: Cortelli, Sheila Cavalca
Data de Publicação: 2003
Outros Autores: Jorge, Antonio Olavo Cardoso [UNESP], Cortelli, José Roberto, Jordan, Shawn Francis, Haraszthy, Violet Ibyola
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1517-74912003000200016
http://hdl.handle.net/11449/213014
Resumo: This study examined the prevalence of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans in patients with periodontal disease. Pooled subgingival plaque samples from 136 patients with some form of periodontal disease were examined. Subjects were between 14 and 76 years of age. Clinical examinations included periodontal pocket depth (PD), plaque index (PI) and bleeding index (BI). The obtained plaque samples were examined for the presence of highly or minimally leukotoxic A. actinomycetemcomitans strains by the polymerase chain reaction (PCR). Chi-square and logistic regression were performed to evaluate the results. Forty-seven subjects were diagnosed with gingivitis, 70 with chronic periodontitis and 19 with aggressive periodontitis. According to chi-square there was no significant correlation detected between PD (chi2 = 0.73), PI (chi2 = 0.35), BI (chi2 = 0.09) and the presence of the highly leukotoxic A. actinomycetemcomitans. The highly leukotoxic A. actinomycetemcomitans strains were correlated with subjects that were 28 years of age and younger (chi2 = 7.41). There was a significant correlation between highly leukotoxic A. actinomycetemcomitans and aggressive periodontitis (chi2 = 22.06). This study of a Brazilian cohort confirms the strong association between highly leukotoxic A. actinomycetemcomitans strains and the presence of aggressive periodontitis.
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spelling Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal diseaseDetecção de cepas de Actinobacillus actinomycetemcomitans de máxima e mínima leucotoxicidade em pacientes com doença periodontalActinobacillus actinomycetemcomitansLeukotoxinGingivitisPeriodontitisPolymerase chain reactionActinobacillus actinomycetemcomitansLeucotoxinaGengivitePeriodontiteReação em cadeia da polimeraseThis study examined the prevalence of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans in patients with periodontal disease. Pooled subgingival plaque samples from 136 patients with some form of periodontal disease were examined. Subjects were between 14 and 76 years of age. Clinical examinations included periodontal pocket depth (PD), plaque index (PI) and bleeding index (BI). The obtained plaque samples were examined for the presence of highly or minimally leukotoxic A. actinomycetemcomitans strains by the polymerase chain reaction (PCR). Chi-square and logistic regression were performed to evaluate the results. Forty-seven subjects were diagnosed with gingivitis, 70 with chronic periodontitis and 19 with aggressive periodontitis. According to chi-square there was no significant correlation detected between PD (chi2 = 0.73), PI (chi2 = 0.35), BI (chi2 = 0.09) and the presence of the highly leukotoxic A. actinomycetemcomitans. The highly leukotoxic A. actinomycetemcomitans strains were correlated with subjects that were 28 years of age and younger (chi2 = 7.41). There was a significant correlation between highly leukotoxic A. actinomycetemcomitans and aggressive periodontitis (chi2 = 22.06). This study of a Brazilian cohort confirms the strong association between highly leukotoxic A. actinomycetemcomitans strains and the presence of aggressive periodontitis.O presente estudo avaliou a prevalência de Actinobacillus actinomycetemcomitans de máxima e mínima leucotoxicidade em indivíduos com doença periodontal. Foram analisadas amostras de placa bacteriana subgengival de 136 indivíduos, entre 14 e 76 anos de idade, com algum tipo de doença periodontal. Os parâmetros clínicos avaliados incluíram profundidade de sondagem (PS), índice de placa bacteriana (IPB) e índice de sangramento gengival (ISG). A presença de amostras de A. actinomycetemcomitans de máxima e mínima leucotoxicidade foi avaliada por reação em cadeia da polimerase (PCR). Os resultados foram analisados empregando-se teste qui-quadrado e análise de regressão logística. Quarenta e sete indivíduos apresentaram gengivite, 70 indivíduos periodontite crônica e 19 indivíduos periodontite agressiva. O teste qui-quadrado não demonstrou correlação significativa entre PS (chi2 = 0,73), IPB (chi2 = 0,35), ISG (chi2 = 0,09) e a presença de amostras de máxima leucotoxicidade. A. actinomycetemcomitans de máxima leucotoxicidade apresentou associação com indivíduos com idade inferior a 28 anos (chi2 = 22,06). Os resultados observados nessa população brasileira confirmam a forte associação existente entre amostras de A. actinomycetemcomitans de máxima leucotoxicidade e periodontite agressiva.State University of New York, School of Dental MedicineUniversidade Estadual PaulistaUniversity of TaubatéUniversidade Estadual PaulistaSociedade Brasileira de Pesquisa Odontológica e Faculdade de Odontologia da Universidade de São PauloState University of New YorkUniversidade Estadual Paulista (Unesp)University of TaubatéCortelli, Sheila CavalcaJorge, Antonio Olavo Cardoso [UNESP]Cortelli, José RobertoJordan, Shawn FrancisHaraszthy, Violet Ibyola2021-07-14T10:48:39Z2021-07-14T10:48:39Z2003-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article183-188application/pdfhttp://dx.doi.org/10.1590/S1517-74912003000200016Pesquisa Odontológica Brasileira. São Paulo, SP, Brazil: Sociedade Brasileira de Pesquisa Odontológica e Faculdade de Odontologia da Universidade de São Paulo, v. 17, n. 2, p. 183-188, 2003.1517-7491http://hdl.handle.net/11449/21301410.1590/S1517-74912003000200016S1517-74912003000200016S1517-74912003000200016.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Odontológica Brasileirainfo:eu-repo/semantics/openAccess2023-12-19T06:26:27Zoai:repositorio.unesp.br:11449/213014Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:46:40.940940Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
Detecção de cepas de Actinobacillus actinomycetemcomitans de máxima e mínima leucotoxicidade em pacientes com doença periodontal
title Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
spellingShingle Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
Cortelli, Sheila Cavalca
Actinobacillus actinomycetemcomitans
Leukotoxin
Gingivitis
Periodontitis
Polymerase chain reaction
Actinobacillus actinomycetemcomitans
Leucotoxina
Gengivite
Periodontite
Reação em cadeia da polimerase
title_short Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
title_full Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
title_fullStr Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
title_full_unstemmed Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
title_sort Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease
author Cortelli, Sheila Cavalca
author_facet Cortelli, Sheila Cavalca
Jorge, Antonio Olavo Cardoso [UNESP]
Cortelli, José Roberto
Jordan, Shawn Francis
Haraszthy, Violet Ibyola
author_role author
author2 Jorge, Antonio Olavo Cardoso [UNESP]
Cortelli, José Roberto
Jordan, Shawn Francis
Haraszthy, Violet Ibyola
author2_role author
author
author
author
dc.contributor.none.fl_str_mv State University of New York
Universidade Estadual Paulista (Unesp)
University of Taubaté
dc.contributor.author.fl_str_mv Cortelli, Sheila Cavalca
Jorge, Antonio Olavo Cardoso [UNESP]
Cortelli, José Roberto
Jordan, Shawn Francis
Haraszthy, Violet Ibyola
dc.subject.por.fl_str_mv Actinobacillus actinomycetemcomitans
Leukotoxin
Gingivitis
Periodontitis
Polymerase chain reaction
Actinobacillus actinomycetemcomitans
Leucotoxina
Gengivite
Periodontite
Reação em cadeia da polimerase
topic Actinobacillus actinomycetemcomitans
Leukotoxin
Gingivitis
Periodontitis
Polymerase chain reaction
Actinobacillus actinomycetemcomitans
Leucotoxina
Gengivite
Periodontite
Reação em cadeia da polimerase
description This study examined the prevalence of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans in patients with periodontal disease. Pooled subgingival plaque samples from 136 patients with some form of periodontal disease were examined. Subjects were between 14 and 76 years of age. Clinical examinations included periodontal pocket depth (PD), plaque index (PI) and bleeding index (BI). The obtained plaque samples were examined for the presence of highly or minimally leukotoxic A. actinomycetemcomitans strains by the polymerase chain reaction (PCR). Chi-square and logistic regression were performed to evaluate the results. Forty-seven subjects were diagnosed with gingivitis, 70 with chronic periodontitis and 19 with aggressive periodontitis. According to chi-square there was no significant correlation detected between PD (chi2 = 0.73), PI (chi2 = 0.35), BI (chi2 = 0.09) and the presence of the highly leukotoxic A. actinomycetemcomitans. The highly leukotoxic A. actinomycetemcomitans strains were correlated with subjects that were 28 years of age and younger (chi2 = 7.41). There was a significant correlation between highly leukotoxic A. actinomycetemcomitans and aggressive periodontitis (chi2 = 22.06). This study of a Brazilian cohort confirms the strong association between highly leukotoxic A. actinomycetemcomitans strains and the presence of aggressive periodontitis.
publishDate 2003
dc.date.none.fl_str_mv 2003-06
2021-07-14T10:48:39Z
2021-07-14T10:48:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1517-74912003000200016
Pesquisa Odontológica Brasileira. São Paulo, SP, Brazil: Sociedade Brasileira de Pesquisa Odontológica e Faculdade de Odontologia da Universidade de São Paulo, v. 17, n. 2, p. 183-188, 2003.
1517-7491
http://hdl.handle.net/11449/213014
10.1590/S1517-74912003000200016
S1517-74912003000200016
S1517-74912003000200016.pdf
url http://dx.doi.org/10.1590/S1517-74912003000200016
http://hdl.handle.net/11449/213014
identifier_str_mv Pesquisa Odontológica Brasileira. São Paulo, SP, Brazil: Sociedade Brasileira de Pesquisa Odontológica e Faculdade de Odontologia da Universidade de São Paulo, v. 17, n. 2, p. 183-188, 2003.
1517-7491
10.1590/S1517-74912003000200016
S1517-74912003000200016
S1517-74912003000200016.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pesquisa Odontológica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 183-188
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica e Faculdade de Odontologia da Universidade de São Paulo
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica e Faculdade de Odontologia da Universidade de São Paulo
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129247188877312

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