Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols

Detalhes bibliográficos
Autor(a) principal: da Rocha, Claudia Quintino [UNESP]
Data de Publicação: 2017
Outros Autores: de-Faria, Felipe Meira, Marcourt, Laurence, Ebrahimi, Samad Nejad, Kitano, Bruna Tiemi, Ghilardi, Amanda Franceschini, Luiz Ferreira, Anderson, de Almeida, Ana Cristina Alves, Dunder, Ricardo José, Souza-Brito, Alba Regina Monteiro, Hamburger, Matthias, Vilegas, Wagner [UNESP], Queiroz, Emerson Ferreira, Wolfender, Jean-Luc
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.phytochem.2016.12.002
http://hdl.handle.net/11449/174026
Resumo: The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.
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spelling Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenolsArrabidaea brachypodaBignoniaceaeGastric ulcerGastroprotective effectGlycosylated dimeric flavonoidsIn vivo assaysThe hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.Institute of Biosciences Coastal Campus of São Vicente Universidade Estadual Paulista-UNESPSchool of Pharmaceutical Sciences University of Geneva University of Lausanne Centre Medical Universitaire-CMU, Rue Michel-Servet 1Department of Pharmacology Faculty of Medical Sciences State University of Campinas-UNICAMPDepartment of Structural and Functional Biology Institute of Biology State University of Campinas-UNICAMPDepartment of Phytochemistry Medicinal Plants and Drugs Research Institute Shahid Beheshti University, G. C., EvinNucleus of Biological Sciences Institute of Biotechnology Federal University of GoiasDivision of Pharmaceutical Biology Department of Pharmaceutical Sciences University of Basel, Klingelbergstrasse 50Institute of Biosciences Coastal Campus of São Vicente Universidade Estadual Paulista-UNESPUniversidade Estadual Paulista (Unesp)Centre Medical Universitaire-CMUUniversidade Estadual de Campinas (UNICAMP)Shahid Beheshti UniversityFederal University of GoiasUniversity of Baselda Rocha, Claudia Quintino [UNESP]de-Faria, Felipe MeiraMarcourt, LaurenceEbrahimi, Samad NejadKitano, Bruna TiemiGhilardi, Amanda FranceschiniLuiz Ferreira, Andersonde Almeida, Ana Cristina AlvesDunder, Ricardo JoséSouza-Brito, Alba Regina MonteiroHamburger, MatthiasVilegas, Wagner [UNESP]Queiroz, Emerson FerreiraWolfender, Jean-Luc2018-12-11T17:08:48Z2018-12-11T17:08:48Z2017-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article93-105application/pdfhttp://dx.doi.org/10.1016/j.phytochem.2016.12.002Phytochemistry, v. 135, p. 93-105.0031-9422http://hdl.handle.net/11449/17402610.1016/j.phytochem.2016.12.0022-s2.0-850082145842-s2.0-85008214584.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhytochemistry1,048info:eu-repo/semantics/openAccess2023-10-26T06:07:42Zoai:repositorio.unesp.br:11449/174026Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:01:35.695065Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
title Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
spellingShingle Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
da Rocha, Claudia Quintino [UNESP]
Arrabidaea brachypoda
Bignoniaceae
Gastric ulcer
Gastroprotective effect
Glycosylated dimeric flavonoids
In vivo assays
title_short Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
title_full Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
title_fullStr Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
title_full_unstemmed Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
title_sort Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols
author da Rocha, Claudia Quintino [UNESP]
author_facet da Rocha, Claudia Quintino [UNESP]
de-Faria, Felipe Meira
Marcourt, Laurence
Ebrahimi, Samad Nejad
Kitano, Bruna Tiemi
Ghilardi, Amanda Franceschini
Luiz Ferreira, Anderson
de Almeida, Ana Cristina Alves
Dunder, Ricardo José
Souza-Brito, Alba Regina Monteiro
Hamburger, Matthias
Vilegas, Wagner [UNESP]
Queiroz, Emerson Ferreira
Wolfender, Jean-Luc
author_role author
author2 de-Faria, Felipe Meira
Marcourt, Laurence
Ebrahimi, Samad Nejad
Kitano, Bruna Tiemi
Ghilardi, Amanda Franceschini
Luiz Ferreira, Anderson
de Almeida, Ana Cristina Alves
Dunder, Ricardo José
Souza-Brito, Alba Regina Monteiro
Hamburger, Matthias
Vilegas, Wagner [UNESP]
Queiroz, Emerson Ferreira
Wolfender, Jean-Luc
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Centre Medical Universitaire-CMU
Universidade Estadual de Campinas (UNICAMP)
Shahid Beheshti University
Federal University of Goias
University of Basel
dc.contributor.author.fl_str_mv da Rocha, Claudia Quintino [UNESP]
de-Faria, Felipe Meira
Marcourt, Laurence
Ebrahimi, Samad Nejad
Kitano, Bruna Tiemi
Ghilardi, Amanda Franceschini
Luiz Ferreira, Anderson
de Almeida, Ana Cristina Alves
Dunder, Ricardo José
Souza-Brito, Alba Regina Monteiro
Hamburger, Matthias
Vilegas, Wagner [UNESP]
Queiroz, Emerson Ferreira
Wolfender, Jean-Luc
dc.subject.por.fl_str_mv Arrabidaea brachypoda
Bignoniaceae
Gastric ulcer
Gastroprotective effect
Glycosylated dimeric flavonoids
In vivo assays
topic Arrabidaea brachypoda
Bignoniaceae
Gastric ulcer
Gastroprotective effect
Glycosylated dimeric flavonoids
In vivo assays
description The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
2018-12-11T17:08:48Z
2018-12-11T17:08:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.phytochem.2016.12.002
Phytochemistry, v. 135, p. 93-105.
0031-9422
http://hdl.handle.net/11449/174026
10.1016/j.phytochem.2016.12.002
2-s2.0-85008214584
2-s2.0-85008214584.pdf
url http://dx.doi.org/10.1016/j.phytochem.2016.12.002
http://hdl.handle.net/11449/174026
identifier_str_mv Phytochemistry, v. 135, p. 93-105.
0031-9422
10.1016/j.phytochem.2016.12.002
2-s2.0-85008214584
2-s2.0-85008214584.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Phytochemistry
1,048
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 93-105
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128595108823040

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