Cellular functionality on nanotubes of Ti-30Ta alloy

Detalhes bibliográficos
Autor(a) principal: Capellato, Patricia [UNESP]
Data de Publicação: 2015
Outros Autores: Smith, Barbara S, Popat, Ketul C., Alves Claro, Ana P. R. [UNESP]
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4028/www.scientific.net/MSF.805.61
http://hdl.handle.net/11449/167759
Resumo: Recent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H2SO4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.
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spelling Cellular functionality on nanotubes of Ti-30Ta alloyHuman dermal fibroblastsTi-30Ta nanotube arraysRecent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H2SO4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.Department of Materials, UNESP- Univ. Estadual Paulista, Av. Ariberto Pereira da Cunha, 333School of Biomedical Engineering, Colorado State UniversityDepart of Mechanical Engineering, Colorado State UniversityDepartment of Materials, UNESP- Univ. Estadual Paulista, Av. Ariberto Pereira da Cunha, 333Universidade Estadual Paulista (Unesp)School of Biomedical Engineering, Colorado State UniversityCapellato, Patricia [UNESP]Smith, Barbara SPopat, Ketul C.Alves Claro, Ana P. R. [UNESP]2018-12-11T16:38:13Z2018-12-11T16:38:13Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject61-64http://dx.doi.org/10.4028/www.scientific.net/MSF.805.61Materials Science Forum, v. 805, p. 61-64.0255-5476http://hdl.handle.net/11449/16775910.4028/www.scientific.net/MSF.805.612-s2.0-84922238460Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Science Forum0,180info:eu-repo/semantics/openAccess2021-10-23T16:01:14Zoai:repositorio.unesp.br:11449/167759Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:52:33.119489Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cellular functionality on nanotubes of Ti-30Ta alloy
title Cellular functionality on nanotubes of Ti-30Ta alloy
spellingShingle Cellular functionality on nanotubes of Ti-30Ta alloy
Capellato, Patricia [UNESP]
Human dermal fibroblasts
Ti-30Ta nanotube arrays
title_short Cellular functionality on nanotubes of Ti-30Ta alloy
title_full Cellular functionality on nanotubes of Ti-30Ta alloy
title_fullStr Cellular functionality on nanotubes of Ti-30Ta alloy
title_full_unstemmed Cellular functionality on nanotubes of Ti-30Ta alloy
title_sort Cellular functionality on nanotubes of Ti-30Ta alloy
author Capellato, Patricia [UNESP]
author_facet Capellato, Patricia [UNESP]
Smith, Barbara S
Popat, Ketul C.
Alves Claro, Ana P. R. [UNESP]
author_role author
author2 Smith, Barbara S
Popat, Ketul C.
Alves Claro, Ana P. R. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
School of Biomedical Engineering, Colorado State University
dc.contributor.author.fl_str_mv Capellato, Patricia [UNESP]
Smith, Barbara S
Popat, Ketul C.
Alves Claro, Ana P. R. [UNESP]
dc.subject.por.fl_str_mv Human dermal fibroblasts
Ti-30Ta nanotube arrays
topic Human dermal fibroblasts
Ti-30Ta nanotube arrays
description Recent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H2SO4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
2018-12-11T16:38:13Z
2018-12-11T16:38:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4028/www.scientific.net/MSF.805.61
Materials Science Forum, v. 805, p. 61-64.
0255-5476
http://hdl.handle.net/11449/167759
10.4028/www.scientific.net/MSF.805.61
2-s2.0-84922238460
url http://dx.doi.org/10.4028/www.scientific.net/MSF.805.61
http://hdl.handle.net/11449/167759
identifier_str_mv Materials Science Forum, v. 805, p. 61-64.
0255-5476
10.4028/www.scientific.net/MSF.805.61
2-s2.0-84922238460
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials Science Forum
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 61-64
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reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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reponame_str Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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