Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.foodres.2019.01.033 http://hdl.handle.net/11449/188654 |
Resumo: | Due to the lack of regulated drugs for aquaculture, the present study considered specific issues relating to environmental and food safety aspects concerning the potential use of emamectin benzoate (EMA) in freshwater fishes such as tilapia (Oreochromis niloticus) – an important commercial fish species worldwide. The residual depletion of EMA (EMA-B 1a ) in fillet (muscle plus skin in natural proportions) of tilapia treated with a daily dose of 50 μg/kg BW during seven consecutive days was evaluated. To facilitate this, analytical methods for quantitation of EMA in fish feed and in fish fillet employing LC-MS/MS were developed and validated. To eliminate the risk of EMA leaching from feed into the aquatic environment during fish medication via oral administration, a promising procedure for drug incorporation into feed involving the coating of feed pellets with ethyl cellulose polymer containing EMA was evaluated. The medicated feed exhibited good homogeneity (CV < 2.1%) with negligible EMA release (< LOQ) when the medicated feed remained in the water for up to 20 min. Depletion study analysis revealed the highest EMA concentration obtained in fish fillet to be 13.3 ng/g. Therefore, under the employed rearing conditions of this study, the obtained results did not evidence requirement for a minimum withdrawal period to be proposed considering the maximum residue limit of 100 μg/g for fish muscle. In response to the well-recognized demands and need for new alternative veterinary drugs for use within aquaculture, this study offers impetus for consideration of EMA use in tilapia taking into account environmental contamination and food safety issues. |
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Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion studyAquacultureEmamectin benzoateFood safetyResidual depletionTilapiaVeterinary drug residuesWithdrawal periodDue to the lack of regulated drugs for aquaculture, the present study considered specific issues relating to environmental and food safety aspects concerning the potential use of emamectin benzoate (EMA) in freshwater fishes such as tilapia (Oreochromis niloticus) – an important commercial fish species worldwide. The residual depletion of EMA (EMA-B 1a ) in fillet (muscle plus skin in natural proportions) of tilapia treated with a daily dose of 50 μg/kg BW during seven consecutive days was evaluated. To facilitate this, analytical methods for quantitation of EMA in fish feed and in fish fillet employing LC-MS/MS were developed and validated. To eliminate the risk of EMA leaching from feed into the aquatic environment during fish medication via oral administration, a promising procedure for drug incorporation into feed involving the coating of feed pellets with ethyl cellulose polymer containing EMA was evaluated. The medicated feed exhibited good homogeneity (CV < 2.1%) with negligible EMA release (< LOQ) when the medicated feed remained in the water for up to 20 min. Depletion study analysis revealed the highest EMA concentration obtained in fish fillet to be 13.3 ng/g. Therefore, under the employed rearing conditions of this study, the obtained results did not evidence requirement for a minimum withdrawal period to be proposed considering the maximum residue limit of 100 μg/g for fish muscle. In response to the well-recognized demands and need for new alternative veterinary drugs for use within aquaculture, this study offers impetus for consideration of EMA use in tilapia taking into account environmental contamination and food safety issues.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Faculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Física e Química Universidade de São Paulo (USP)Centro de Aquacultura da Unesp Universidade do Estado de São Paulo (Unesp)Faculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Ciências Farmacêuticas Universidade de São Paulo (USP)Institute for Global Food Security School of Biological Sciences Queen's University BelfastCentro de Aquacultura da Unesp Universidade do Estado de São Paulo (Unesp)FAPESP: 2012/18334-0FAPESP: 2014/50755-0Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Queen's University BelfastNeto, Pedro Fraccarollida Silva, Agnaldo Fernando BaldoMoro, Evandro Bilha [UNESP]Pilarski, Fabiana [UNESP]de Freitas, OsvaldoMooney, Mark H.Paschoal, Jonas Augusto Rizzato2019-10-06T16:15:00Z2019-10-06T16:15:00Z2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article524-529http://dx.doi.org/10.1016/j.foodres.2019.01.033Food Research International, v. 119, p. 524-529.1873-71450963-9969http://hdl.handle.net/11449/18865410.1016/j.foodres.2019.01.0332-s2.0-85060350844Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood Research Internationalinfo:eu-repo/semantics/openAccess2024-04-09T15:43:17Zoai:repositorio.unesp.br:11449/188654Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:17:30.676351Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study |
title |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study |
spellingShingle |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study Neto, Pedro Fraccarolli Aquaculture Emamectin benzoate Food safety Residual depletion Tilapia Veterinary drug residues Withdrawal period |
title_short |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study |
title_full |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study |
title_fullStr |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study |
title_full_unstemmed |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study |
title_sort |
Emamectin benzoate in tilapia: Alternative method for drug incorporation into feed and associated residual depletion study |
author |
Neto, Pedro Fraccarolli |
author_facet |
Neto, Pedro Fraccarolli da Silva, Agnaldo Fernando Baldo Moro, Evandro Bilha [UNESP] Pilarski, Fabiana [UNESP] de Freitas, Osvaldo Mooney, Mark H. Paschoal, Jonas Augusto Rizzato |
author_role |
author |
author2 |
da Silva, Agnaldo Fernando Baldo Moro, Evandro Bilha [UNESP] Pilarski, Fabiana [UNESP] de Freitas, Osvaldo Mooney, Mark H. Paschoal, Jonas Augusto Rizzato |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Queen's University Belfast |
dc.contributor.author.fl_str_mv |
Neto, Pedro Fraccarolli da Silva, Agnaldo Fernando Baldo Moro, Evandro Bilha [UNESP] Pilarski, Fabiana [UNESP] de Freitas, Osvaldo Mooney, Mark H. Paschoal, Jonas Augusto Rizzato |
dc.subject.por.fl_str_mv |
Aquaculture Emamectin benzoate Food safety Residual depletion Tilapia Veterinary drug residues Withdrawal period |
topic |
Aquaculture Emamectin benzoate Food safety Residual depletion Tilapia Veterinary drug residues Withdrawal period |
description |
Due to the lack of regulated drugs for aquaculture, the present study considered specific issues relating to environmental and food safety aspects concerning the potential use of emamectin benzoate (EMA) in freshwater fishes such as tilapia (Oreochromis niloticus) – an important commercial fish species worldwide. The residual depletion of EMA (EMA-B 1a ) in fillet (muscle plus skin in natural proportions) of tilapia treated with a daily dose of 50 μg/kg BW during seven consecutive days was evaluated. To facilitate this, analytical methods for quantitation of EMA in fish feed and in fish fillet employing LC-MS/MS were developed and validated. To eliminate the risk of EMA leaching from feed into the aquatic environment during fish medication via oral administration, a promising procedure for drug incorporation into feed involving the coating of feed pellets with ethyl cellulose polymer containing EMA was evaluated. The medicated feed exhibited good homogeneity (CV < 2.1%) with negligible EMA release (< LOQ) when the medicated feed remained in the water for up to 20 min. Depletion study analysis revealed the highest EMA concentration obtained in fish fillet to be 13.3 ng/g. Therefore, under the employed rearing conditions of this study, the obtained results did not evidence requirement for a minimum withdrawal period to be proposed considering the maximum residue limit of 100 μg/g for fish muscle. In response to the well-recognized demands and need for new alternative veterinary drugs for use within aquaculture, this study offers impetus for consideration of EMA use in tilapia taking into account environmental contamination and food safety issues. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:15:00Z 2019-10-06T16:15:00Z 2019-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.foodres.2019.01.033 Food Research International, v. 119, p. 524-529. 1873-7145 0963-9969 http://hdl.handle.net/11449/188654 10.1016/j.foodres.2019.01.033 2-s2.0-85060350844 |
url |
http://dx.doi.org/10.1016/j.foodres.2019.01.033 http://hdl.handle.net/11449/188654 |
identifier_str_mv |
Food Research International, v. 119, p. 524-529. 1873-7145 0963-9969 10.1016/j.foodres.2019.01.033 2-s2.0-85060350844 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food Research International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
524-529 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129413908267008 |