Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts

Detalhes bibliográficos
Autor(a) principal: Regasini, Luis Octávio [UNESP]
Data de Publicação: 2009
Outros Autores: Cotinguiba, Fernando [UNESP], Morandim, Andreia De Araújo [UNESP], Kato, Massuo Jorge, Scorzoni, Liliana [UNESP], Mendes-Giannini, Maria José [UNESP], Bolzani, Vanderlan Da Silva [UNESP], Furlan, Maysa [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/225537
Resumo: In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values (in μ g/ml) of 15.6 and 31.2 μ g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 μ g/ml against C. krusei, C. parapsilosis and C. neoformans. © 2009 Academic Journals.
id UNSP_207d071b4106ceb3609c6da5879181cb
oai_identifier_str oai:repositorio.unesp.br:11449/225537
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeastsAntifungalAntimicrobialCandidaCryptococcus neoformansPiper arboreumPiper tuberculatumPiperaceaeIn the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values (in μ g/ml) of 15.6 and 31.2 μ g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 μ g/ml against C. krusei, C. parapsilosis and C. neoformans. © 2009 Academic Journals.Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), AraraquaraDepartment of Fundamental Chemistry Institute of Chemistry São Paulo University (USP), São PauloDepartment of Clinical and Toxicological Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), AraraquaraDepartment of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), AraraquaraDepartment of Clinical and Toxicological Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), AraraquaraUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Regasini, Luis Octávio [UNESP]Cotinguiba, Fernando [UNESP]Morandim, Andreia De Araújo [UNESP]Kato, Massuo JorgeScorzoni, Liliana [UNESP]Mendes-Giannini, Maria José [UNESP]Bolzani, Vanderlan Da Silva [UNESP]Furlan, Maysa [UNESP]2022-04-28T20:54:01Z2022-04-28T20:54:01Z2009-06-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2866-2870African Journal of Biotechnology, v. 8, n. 12, p. 2866-2870, 2009.1684-5315http://hdl.handle.net/11449/2255372-s2.0-67650477446Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Biotechnologyinfo:eu-repo/semantics/openAccess2024-06-24T14:51:22Zoai:repositorio.unesp.br:11449/225537Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:36:58.157354Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
spellingShingle Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
Regasini, Luis Octávio [UNESP]
Antifungal
Antimicrobial
Candida
Cryptococcus neoformans
Piper arboreum
Piper tuberculatum
Piperaceae
title_short Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_full Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_fullStr Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_full_unstemmed Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_sort Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
author Regasini, Luis Octávio [UNESP]
author_facet Regasini, Luis Octávio [UNESP]
Cotinguiba, Fernando [UNESP]
Morandim, Andreia De Araújo [UNESP]
Kato, Massuo Jorge
Scorzoni, Liliana [UNESP]
Mendes-Giannini, Maria José [UNESP]
Bolzani, Vanderlan Da Silva [UNESP]
Furlan, Maysa [UNESP]
author_role author
author2 Cotinguiba, Fernando [UNESP]
Morandim, Andreia De Araújo [UNESP]
Kato, Massuo Jorge
Scorzoni, Liliana [UNESP]
Mendes-Giannini, Maria José [UNESP]
Bolzani, Vanderlan Da Silva [UNESP]
Furlan, Maysa [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Regasini, Luis Octávio [UNESP]
Cotinguiba, Fernando [UNESP]
Morandim, Andreia De Araújo [UNESP]
Kato, Massuo Jorge
Scorzoni, Liliana [UNESP]
Mendes-Giannini, Maria José [UNESP]
Bolzani, Vanderlan Da Silva [UNESP]
Furlan, Maysa [UNESP]
dc.subject.por.fl_str_mv Antifungal
Antimicrobial
Candida
Cryptococcus neoformans
Piper arboreum
Piper tuberculatum
Piperaceae
topic Antifungal
Antimicrobial
Candida
Cryptococcus neoformans
Piper arboreum
Piper tuberculatum
Piperaceae
description In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values (in μ g/ml) of 15.6 and 31.2 μ g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 μ g/ml against C. krusei, C. parapsilosis and C. neoformans. © 2009 Academic Journals.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-17
2022-04-28T20:54:01Z
2022-04-28T20:54:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv African Journal of Biotechnology, v. 8, n. 12, p. 2866-2870, 2009.
1684-5315
http://hdl.handle.net/11449/225537
2-s2.0-67650477446
identifier_str_mv African Journal of Biotechnology, v. 8, n. 12, p. 2866-2870, 2009.
1684-5315
2-s2.0-67650477446
url http://hdl.handle.net/11449/225537
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv African Journal of Biotechnology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2866-2870
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128254500929536