Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/225537 |
Resumo: | In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values (in μ g/ml) of 15.6 and 31.2 μ g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 μ g/ml against C. krusei, C. parapsilosis and C. neoformans. © 2009 Academic Journals. |
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Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeastsAntifungalAntimicrobialCandidaCryptococcus neoformansPiper arboreumPiper tuberculatumPiperaceaeIn the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values (in μ g/ml) of 15.6 and 31.2 μ g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 μ g/ml against C. krusei, C. parapsilosis and C. neoformans. © 2009 Academic Journals.Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), AraraquaraDepartment of Fundamental Chemistry Institute of Chemistry São Paulo University (USP), São PauloDepartment of Clinical and Toxicological Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), AraraquaraDepartment of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), AraraquaraDepartment of Clinical and Toxicological Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), AraraquaraUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Regasini, Luis Octávio [UNESP]Cotinguiba, Fernando [UNESP]Morandim, Andreia De Araújo [UNESP]Kato, Massuo JorgeScorzoni, Liliana [UNESP]Mendes-Giannini, Maria José [UNESP]Bolzani, Vanderlan Da Silva [UNESP]Furlan, Maysa [UNESP]2022-04-28T20:54:01Z2022-04-28T20:54:01Z2009-06-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2866-2870African Journal of Biotechnology, v. 8, n. 12, p. 2866-2870, 2009.1684-5315http://hdl.handle.net/11449/2255372-s2.0-67650477446Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Biotechnologyinfo:eu-repo/semantics/openAccess2024-06-24T14:51:22Zoai:repositorio.unesp.br:11449/225537Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:36:58.157354Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
spellingShingle |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts Regasini, Luis Octávio [UNESP] Antifungal Antimicrobial Candida Cryptococcus neoformans Piper arboreum Piper tuberculatum Piperaceae |
title_short |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_full |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_fullStr |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_full_unstemmed |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_sort |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
author |
Regasini, Luis Octávio [UNESP] |
author_facet |
Regasini, Luis Octávio [UNESP] Cotinguiba, Fernando [UNESP] Morandim, Andreia De Araújo [UNESP] Kato, Massuo Jorge Scorzoni, Liliana [UNESP] Mendes-Giannini, Maria José [UNESP] Bolzani, Vanderlan Da Silva [UNESP] Furlan, Maysa [UNESP] |
author_role |
author |
author2 |
Cotinguiba, Fernando [UNESP] Morandim, Andreia De Araújo [UNESP] Kato, Massuo Jorge Scorzoni, Liliana [UNESP] Mendes-Giannini, Maria José [UNESP] Bolzani, Vanderlan Da Silva [UNESP] Furlan, Maysa [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Regasini, Luis Octávio [UNESP] Cotinguiba, Fernando [UNESP] Morandim, Andreia De Araújo [UNESP] Kato, Massuo Jorge Scorzoni, Liliana [UNESP] Mendes-Giannini, Maria José [UNESP] Bolzani, Vanderlan Da Silva [UNESP] Furlan, Maysa [UNESP] |
dc.subject.por.fl_str_mv |
Antifungal Antimicrobial Candida Cryptococcus neoformans Piper arboreum Piper tuberculatum Piperaceae |
topic |
Antifungal Antimicrobial Candida Cryptococcus neoformans Piper arboreum Piper tuberculatum Piperaceae |
description |
In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values (in μ g/ml) of 15.6 and 31.2 μ g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 μ g/ml against C. krusei, C. parapsilosis and C. neoformans. © 2009 Academic Journals. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-17 2022-04-28T20:54:01Z 2022-04-28T20:54:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
African Journal of Biotechnology, v. 8, n. 12, p. 2866-2870, 2009. 1684-5315 http://hdl.handle.net/11449/225537 2-s2.0-67650477446 |
identifier_str_mv |
African Journal of Biotechnology, v. 8, n. 12, p. 2866-2870, 2009. 1684-5315 2-s2.0-67650477446 |
url |
http://hdl.handle.net/11449/225537 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
African Journal of Biotechnology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2866-2870 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128254500929536 |