Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5897/AJB09.182 http://hdl.handle.net/11449/26366 |
Resumo: | In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values ( in mu g/ml) of 15.6 and 31.2 mu g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 mu g/ml against C. krusei, C. parapsilosis and C. neoformans. |
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Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeastsAntifungalantimicrobialPiper arboreumPiper tuberculatumPiperaceaeCandidaCryptococcus neoformansIn the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values ( in mu g/ml) of 15.6 and 31.2 mu g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 mu g/ml against C. krusei, C. parapsilosis and C. neoformans.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)São Paulo State Univ, UNESP, Inst Chem, Dept Organ Chem, Araraquara, BrazilUniv São Paulo, UNESP, Inst Chem, Dept Fundamental Chem, São Paulo, BrazilSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Araraquara, BrazilSão Paulo State Univ, UNESP, Inst Chem, Dept Organ Chem, Araraquara, BrazilUniv São Paulo, UNESP, Inst Chem, Dept Fundamental Chem, São Paulo, BrazilSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Araraquara, BrazilAcademic JournalsUniversidade Estadual Paulista (Unesp)Regasini, Luis Octavio [UNESP]Cotinguiba, Fernando [UNESP]Morandim, Andreia de Araujo [UNESP]Kato, Massuo Jorge [UNESP]Scorzoni, Liliana [UNESP]Mendes-Giannini, Maria José Soares [UNESP]Bolzani, Vanderlan da Silva [UNESP]Furlan, Maysa [UNESP]2014-05-20T14:21:16Z2014-05-20T14:21:16Z2009-06-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2866-2870application/pdfhttp://dx.doi.org/10.5897/AJB09.182African Journal of Biotechnology. Victoria Island: Academic Journals, v. 8, n. 12, p. 2866-2870, 2009.1684-5315http://hdl.handle.net/11449/2636610.5897/AJB09.450WOS:000268831200034WOS000268831200034.pdf448408368525167313080427947868720000-0002-8059-0826Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Biotechnologyinfo:eu-repo/semantics/openAccess2024-06-24T14:51:52Zoai:repositorio.unesp.br:11449/26366Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:44:23.019976Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
spellingShingle |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts Regasini, Luis Octavio [UNESP] Antifungal antimicrobial Piper arboreum Piper tuberculatum Piperaceae Candida Cryptococcus neoformans |
title_short |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_full |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_fullStr |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_full_unstemmed |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
title_sort |
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts |
author |
Regasini, Luis Octavio [UNESP] |
author_facet |
Regasini, Luis Octavio [UNESP] Cotinguiba, Fernando [UNESP] Morandim, Andreia de Araujo [UNESP] Kato, Massuo Jorge [UNESP] Scorzoni, Liliana [UNESP] Mendes-Giannini, Maria José Soares [UNESP] Bolzani, Vanderlan da Silva [UNESP] Furlan, Maysa [UNESP] |
author_role |
author |
author2 |
Cotinguiba, Fernando [UNESP] Morandim, Andreia de Araujo [UNESP] Kato, Massuo Jorge [UNESP] Scorzoni, Liliana [UNESP] Mendes-Giannini, Maria José Soares [UNESP] Bolzani, Vanderlan da Silva [UNESP] Furlan, Maysa [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Regasini, Luis Octavio [UNESP] Cotinguiba, Fernando [UNESP] Morandim, Andreia de Araujo [UNESP] Kato, Massuo Jorge [UNESP] Scorzoni, Liliana [UNESP] Mendes-Giannini, Maria José Soares [UNESP] Bolzani, Vanderlan da Silva [UNESP] Furlan, Maysa [UNESP] |
dc.subject.por.fl_str_mv |
Antifungal antimicrobial Piper arboreum Piper tuberculatum Piperaceae Candida Cryptococcus neoformans |
topic |
Antifungal antimicrobial Piper arboreum Piper tuberculatum Piperaceae Candida Cryptococcus neoformans |
description |
In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values ( in mu g/ml) of 15.6 and 31.2 mu g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 mu g/ml against C. krusei, C. parapsilosis and C. neoformans. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-17 2014-05-20T14:21:16Z 2014-05-20T14:21:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5897/AJB09.182 African Journal of Biotechnology. Victoria Island: Academic Journals, v. 8, n. 12, p. 2866-2870, 2009. 1684-5315 http://hdl.handle.net/11449/26366 10.5897/AJB09.450 WOS:000268831200034 WOS000268831200034.pdf 4484083685251673 1308042794786872 0000-0002-8059-0826 |
url |
http://dx.doi.org/10.5897/AJB09.182 http://hdl.handle.net/11449/26366 |
identifier_str_mv |
African Journal of Biotechnology. Victoria Island: Academic Journals, v. 8, n. 12, p. 2866-2870, 2009. 1684-5315 10.5897/AJB09.450 WOS:000268831200034 WOS000268831200034.pdf 4484083685251673 1308042794786872 0000-0002-8059-0826 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
African Journal of Biotechnology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2866-2870 application/pdf |
dc.publisher.none.fl_str_mv |
Academic Journals |
publisher.none.fl_str_mv |
Academic Journals |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129111042818048 |