Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts

Detalhes bibliográficos
Autor(a) principal: Regasini, Luis Octavio [UNESP]
Data de Publicação: 2009
Outros Autores: Cotinguiba, Fernando [UNESP], Morandim, Andreia de Araujo [UNESP], Kato, Massuo Jorge [UNESP], Scorzoni, Liliana [UNESP], Mendes-Giannini, Maria José Soares [UNESP], Bolzani, Vanderlan da Silva [UNESP], Furlan, Maysa [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5897/AJB09.182
http://hdl.handle.net/11449/26366
Resumo: In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values ( in mu g/ml) of 15.6 and 31.2 mu g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 mu g/ml against C. krusei, C. parapsilosis and C. neoformans.
id UNSP_e975e03476b109519d1a7fb4ac3b400b
oai_identifier_str oai:repositorio.unesp.br:11449/26366
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeastsAntifungalantimicrobialPiper arboreumPiper tuberculatumPiperaceaeCandidaCryptococcus neoformansIn the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values ( in mu g/ml) of 15.6 and 31.2 mu g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 mu g/ml against C. krusei, C. parapsilosis and C. neoformans.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)São Paulo State Univ, UNESP, Inst Chem, Dept Organ Chem, Araraquara, BrazilUniv São Paulo, UNESP, Inst Chem, Dept Fundamental Chem, São Paulo, BrazilSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Araraquara, BrazilSão Paulo State Univ, UNESP, Inst Chem, Dept Organ Chem, Araraquara, BrazilUniv São Paulo, UNESP, Inst Chem, Dept Fundamental Chem, São Paulo, BrazilSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Araraquara, BrazilAcademic JournalsUniversidade Estadual Paulista (Unesp)Regasini, Luis Octavio [UNESP]Cotinguiba, Fernando [UNESP]Morandim, Andreia de Araujo [UNESP]Kato, Massuo Jorge [UNESP]Scorzoni, Liliana [UNESP]Mendes-Giannini, Maria José Soares [UNESP]Bolzani, Vanderlan da Silva [UNESP]Furlan, Maysa [UNESP]2014-05-20T14:21:16Z2014-05-20T14:21:16Z2009-06-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2866-2870application/pdfhttp://dx.doi.org/10.5897/AJB09.182African Journal of Biotechnology. Victoria Island: Academic Journals, v. 8, n. 12, p. 2866-2870, 2009.1684-5315http://hdl.handle.net/11449/2636610.5897/AJB09.450WOS:000268831200034WOS000268831200034.pdf448408368525167313080427947868720000-0002-8059-0826Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Biotechnologyinfo:eu-repo/semantics/openAccess2024-06-24T14:51:52Zoai:repositorio.unesp.br:11449/26366Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:44:23.019976Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
spellingShingle Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
Regasini, Luis Octavio [UNESP]
Antifungal
antimicrobial
Piper arboreum
Piper tuberculatum
Piperaceae
Candida
Cryptococcus neoformans
title_short Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_full Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_fullStr Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_full_unstemmed Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
title_sort Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
author Regasini, Luis Octavio [UNESP]
author_facet Regasini, Luis Octavio [UNESP]
Cotinguiba, Fernando [UNESP]
Morandim, Andreia de Araujo [UNESP]
Kato, Massuo Jorge [UNESP]
Scorzoni, Liliana [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
author_role author
author2 Cotinguiba, Fernando [UNESP]
Morandim, Andreia de Araujo [UNESP]
Kato, Massuo Jorge [UNESP]
Scorzoni, Liliana [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Regasini, Luis Octavio [UNESP]
Cotinguiba, Fernando [UNESP]
Morandim, Andreia de Araujo [UNESP]
Kato, Massuo Jorge [UNESP]
Scorzoni, Liliana [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
dc.subject.por.fl_str_mv Antifungal
antimicrobial
Piper arboreum
Piper tuberculatum
Piperaceae
Candida
Cryptococcus neoformans
topic Antifungal
antimicrobial
Piper arboreum
Piper tuberculatum
Piperaceae
Candida
Cryptococcus neoformans
description In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity by using broth microdilution method. The current investigation reveals that P. arboreum extracts and fractions were more effective against Candida krusei and Candida parapsilosis than Cryptococcus neoformans. The growth of Candida albicans was weakly affected by all the tested extracts and fractions. The strongest effects were observed for hexane and ethyl acetate fractions from leaves of P. arboreum, with MIC values ( in mu g/ml) of 15.6 and 31.2 mu g/ml against C. krusei, respectively. Additionally, phytochemical investigation of the hexane fraction of P. arboreum leaves furnished 3 pyrrolidine amides; piperyline, 4,5-dihydropiperyline and tetrahydropiperyline, which could be responsible, at least in part for the observed antifungal activity. The most active compound, tetrahydropiperyline, displayed MIC values of 15.6 mu g/ml against C. krusei, C. parapsilosis and C. neoformans.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-17
2014-05-20T14:21:16Z
2014-05-20T14:21:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5897/AJB09.182
African Journal of Biotechnology. Victoria Island: Academic Journals, v. 8, n. 12, p. 2866-2870, 2009.
1684-5315
http://hdl.handle.net/11449/26366
10.5897/AJB09.450
WOS:000268831200034
WOS000268831200034.pdf
4484083685251673
1308042794786872
0000-0002-8059-0826
url http://dx.doi.org/10.5897/AJB09.182
http://hdl.handle.net/11449/26366
identifier_str_mv African Journal of Biotechnology. Victoria Island: Academic Journals, v. 8, n. 12, p. 2866-2870, 2009.
1684-5315
10.5897/AJB09.450
WOS:000268831200034
WOS000268831200034.pdf
4484083685251673
1308042794786872
0000-0002-8059-0826
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv African Journal of Biotechnology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2866-2870
application/pdf
dc.publisher.none.fl_str_mv Academic Journals
publisher.none.fl_str_mv Academic Journals
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129111042818048