Neurological manifestations by sex and age group in COVID-19 inhospital patients
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ensci.2022.100419 http://hdl.handle.net/11449/241525 |
Resumo: | Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures. |
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Neurological manifestations by sex and age group in COVID-19 inhospital patientsAgeCOVID-19DeliriumNeurological manifestationsSexIntroduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculdade de Medicina Universidade Federal de Minas GeraisFundação Hospitalar do Estado de Minas Gerais (Fhemig)Hospital Risoleta Tolentino NevesHospitais da Rede Mater DeiHospital Universitário de Santa Maria/EBSERH Universidade Federal de Santa MariaHospital Universitário Ciências MédicasHospital Santa RosáliaHospital das Clínicas da Faculdade de Medicina de BotucatuComplexo da Saúde São João de Deus Universidade Federal de São João del-ReiSanta Casa de Misericórdia de Belo HorizonteHospital Mãe de DeusGrupo Hospitalar Conceição Brazilian National Health System Hospital Nossa Senhora da Conceição and Hospital Cristo RedentorHospital SOS CárdioHospital Santo AntônioUniversidade Federal Fronteira do SulHospital Metropolitano Odilon BehrensHospital Mãe de Deus Hospital Universitário de Canoas Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)Hospital de Clínicas de Porto Alegre IATS/CnPqOrizonti- Instituto Oncomed de Saúde e LongevidadeHospital SemperFaculdade Santa Casa BHDepartment of Internal Medicine Medical School and Telehealth Center University Hospital Universidade Federal de Minas GeraisUniversidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)Institute for Health Technology Assessment (IATS/ CNPq)Campus Centro Oeste Dona Lindu Universidade Federal de São João del-ReiInstituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)Hospital Regional do OesteNeuropsychiatry Program Department of Psychiatry and Behavioral Sciences UT Health HoustonHospital das Clínicas da Faculdade de Medicina de BotucatuCNPq: 147122/2021–0CNPq: 310561/2021–3Universidade Federal de Minas Gerais (UFMG)Fundação Hospitalar do Estado de Minas Gerais (Fhemig)Hospital Risoleta Tolentino NevesHospitais da Rede Mater DeiUniversidade Federal de Santa MariaHospital Universitário Ciências MédicasUniversidade Federal de Viçosa (UFV)Universidade Estadual Paulista (UNESP)Universidade Federal de São João del-ReiSanta Casa de Misericórdia de Belo HorizonteHospital Mãe de DeusHospital Nossa Senhora da Conceição and Hospital Cristo RedentorHospital SOS CárdioHospital Santo AntônioUniversidade Federal Fronteira do SulHospital Metropolitano Odilon BehrensUniversidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)IATS/CnPqOrizonti- Instituto Oncomed de Saúde e LongevidadeHospital SemperFaculdade Santa Casa BHInstitute for Health Technology Assessment (IATS/ CNPq)Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)Hospital Regional do OesteUT Health HoustonPereira, Daniella NunesBicalho, Maria Aparecida CamargosJorge, Alzira de OliveiraGomes, Angélica Gomides dos ReisSchwarzbold, Alexandre VargasAraújo, Anna Luiza HomanCimini, Christiane Corrêa RodriguesPonce, Daniela [UNESP]Rios, Danyelle Romana AlvesGrizende, Genna Maira SantosManenti, Euler Roberto FernandesAnschau, FernandoAranha, Fernando GraçaBartolazzi, FredericoBatista, Joanna d'Arc LyraTupinambás, Julia TeixeiraRuschel, Karen BrasilFerreira, Maria Angélica PiresParaíso, Pedro GibsonAraújo, Silvia FerreiraTeixeira, Antonio LucioMarcolino, Milena Soriano2023-03-01T21:08:02Z2023-03-01T21:08:02Z2022-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ensci.2022.100419eNeurologicalSci, v. 28.2405-6502http://hdl.handle.net/11449/24152510.1016/j.ensci.2022.1004192-s2.0-85136248005Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengeNeurologicalSciinfo:eu-repo/semantics/openAccess2023-03-01T21:08:03Zoai:repositorio.unesp.br:11449/241525Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T21:08:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neurological manifestations by sex and age group in COVID-19 inhospital patients |
title |
Neurological manifestations by sex and age group in COVID-19 inhospital patients |
spellingShingle |
Neurological manifestations by sex and age group in COVID-19 inhospital patients Pereira, Daniella Nunes Age COVID-19 Delirium Neurological manifestations Sex |
title_short |
Neurological manifestations by sex and age group in COVID-19 inhospital patients |
title_full |
Neurological manifestations by sex and age group in COVID-19 inhospital patients |
title_fullStr |
Neurological manifestations by sex and age group in COVID-19 inhospital patients |
title_full_unstemmed |
Neurological manifestations by sex and age group in COVID-19 inhospital patients |
title_sort |
Neurological manifestations by sex and age group in COVID-19 inhospital patients |
author |
Pereira, Daniella Nunes |
author_facet |
Pereira, Daniella Nunes Bicalho, Maria Aparecida Camargos Jorge, Alzira de Oliveira Gomes, Angélica Gomides dos Reis Schwarzbold, Alexandre Vargas Araújo, Anna Luiza Homan Cimini, Christiane Corrêa Rodrigues Ponce, Daniela [UNESP] Rios, Danyelle Romana Alves Grizende, Genna Maira Santos Manenti, Euler Roberto Fernandes Anschau, Fernando Aranha, Fernando Graça Bartolazzi, Frederico Batista, Joanna d'Arc Lyra Tupinambás, Julia Teixeira Ruschel, Karen Brasil Ferreira, Maria Angélica Pires Paraíso, Pedro Gibson Araújo, Silvia Ferreira Teixeira, Antonio Lucio Marcolino, Milena Soriano |
author_role |
author |
author2 |
Bicalho, Maria Aparecida Camargos Jorge, Alzira de Oliveira Gomes, Angélica Gomides dos Reis Schwarzbold, Alexandre Vargas Araújo, Anna Luiza Homan Cimini, Christiane Corrêa Rodrigues Ponce, Daniela [UNESP] Rios, Danyelle Romana Alves Grizende, Genna Maira Santos Manenti, Euler Roberto Fernandes Anschau, Fernando Aranha, Fernando Graça Bartolazzi, Frederico Batista, Joanna d'Arc Lyra Tupinambás, Julia Teixeira Ruschel, Karen Brasil Ferreira, Maria Angélica Pires Paraíso, Pedro Gibson Araújo, Silvia Ferreira Teixeira, Antonio Lucio Marcolino, Milena Soriano |
author2_role |
author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Minas Gerais (UFMG) Fundação Hospitalar do Estado de Minas Gerais (Fhemig) Hospital Risoleta Tolentino Neves Hospitais da Rede Mater Dei Universidade Federal de Santa Maria Hospital Universitário Ciências Médicas Universidade Federal de Viçosa (UFV) Universidade Estadual Paulista (UNESP) Universidade Federal de São João del-Rei Santa Casa de Misericórdia de Belo Horizonte Hospital Mãe de Deus Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor Hospital SOS Cárdio Hospital Santo Antônio Universidade Federal Fronteira do Sul Hospital Metropolitano Odilon Behrens Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ) IATS/CnPq Orizonti- Instituto Oncomed de Saúde e Longevidade Hospital Semper Faculdade Santa Casa BH Institute for Health Technology Assessment (IATS/ CNPq) Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ) Hospital Regional do Oeste UT Health Houston |
dc.contributor.author.fl_str_mv |
Pereira, Daniella Nunes Bicalho, Maria Aparecida Camargos Jorge, Alzira de Oliveira Gomes, Angélica Gomides dos Reis Schwarzbold, Alexandre Vargas Araújo, Anna Luiza Homan Cimini, Christiane Corrêa Rodrigues Ponce, Daniela [UNESP] Rios, Danyelle Romana Alves Grizende, Genna Maira Santos Manenti, Euler Roberto Fernandes Anschau, Fernando Aranha, Fernando Graça Bartolazzi, Frederico Batista, Joanna d'Arc Lyra Tupinambás, Julia Teixeira Ruschel, Karen Brasil Ferreira, Maria Angélica Pires Paraíso, Pedro Gibson Araújo, Silvia Ferreira Teixeira, Antonio Lucio Marcolino, Milena Soriano |
dc.subject.por.fl_str_mv |
Age COVID-19 Delirium Neurological manifestations Sex |
topic |
Age COVID-19 Delirium Neurological manifestations Sex |
description |
Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-01 2023-03-01T21:08:02Z 2023-03-01T21:08:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ensci.2022.100419 eNeurologicalSci, v. 28. 2405-6502 http://hdl.handle.net/11449/241525 10.1016/j.ensci.2022.100419 2-s2.0-85136248005 |
url |
http://dx.doi.org/10.1016/j.ensci.2022.100419 http://hdl.handle.net/11449/241525 |
identifier_str_mv |
eNeurologicalSci, v. 28. 2405-6502 10.1016/j.ensci.2022.100419 2-s2.0-85136248005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
eNeurologicalSci |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
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UNESP |
reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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