Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/cbin.11995 http://hdl.handle.net/11449/248292 |
Resumo: | Several pollutants can alter neonatal prostatic development predisposing this gland to diseases. The toxicity and endocrine disrupting potential of aluminum has been reported in many organs, but little is known about its effects on the prostate. This study aimed to evaluate the effects that aluminum neonatal exposure can cause in the male ventral prostate and in the female prostate of adult and senile gerbils. Male and female pups were treated orally with aluminum chloride (10 mg/kg) from the 1st to the 14th day life. After treatment, the animals were aged until they reached 90 days or 1 year of life. The prostate glands were dissected out and submitted to morphological, immunohistochemical and ultrastructural analyses. Ventral prostates of adult males showed moderate hyperplasia and increased epithelial proliferation not associated with androgen receptor (AR) deregulation. On the other hand, senile males showed intense prostatic hyperplasia, and increased cell proliferation and epithelial AR regulation. Additionally, at both ages, there was a reduction in the prostate secretory function. The morphological changes observed in the female prostate were like those found in males. However, in adult females, prostatic hyperplasia was accompanied by a lower regulation of AR and estrogen receptor alpha, while in senile females, intense hyperplastic growth was associated with an increase in estrogen receptor alpha and a reduction in stromal AR. These results demonstrate that aluminum chloride neonatal exposure alters the hormonal regulation of the male and female prostate, inducing tissue damage that occurs in adulthood and intensifies during aging. |
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Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasiaandrogensendocrine disruptorsestrogensfemale prostatemetalsventral prostateSeveral pollutants can alter neonatal prostatic development predisposing this gland to diseases. The toxicity and endocrine disrupting potential of aluminum has been reported in many organs, but little is known about its effects on the prostate. This study aimed to evaluate the effects that aluminum neonatal exposure can cause in the male ventral prostate and in the female prostate of adult and senile gerbils. Male and female pups were treated orally with aluminum chloride (10 mg/kg) from the 1st to the 14th day life. After treatment, the animals were aged until they reached 90 days or 1 year of life. The prostate glands were dissected out and submitted to morphological, immunohistochemical and ultrastructural analyses. Ventral prostates of adult males showed moderate hyperplasia and increased epithelial proliferation not associated with androgen receptor (AR) deregulation. On the other hand, senile males showed intense prostatic hyperplasia, and increased cell proliferation and epithelial AR regulation. Additionally, at both ages, there was a reduction in the prostate secretory function. The morphological changes observed in the female prostate were like those found in males. However, in adult females, prostatic hyperplasia was accompanied by a lower regulation of AR and estrogen receptor alpha, while in senile females, intense hyperplastic growth was associated with an increase in estrogen receptor alpha and a reduction in stromal AR. These results demonstrate that aluminum chloride neonatal exposure alters the hormonal regulation of the male and female prostate, inducing tissue damage that occurs in adulthood and intensifies during aging.Fundação de Amparo à Pesquisa do Estado de GoiásConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Laboratory of Microscopy Applied to Reproduction Department of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of Goiás, GoiásLaboratory of Microscopy and Microanalysis Department of Biology University Estadual Paulista – UNESP, São PauloLaboratory of Molecular and Biochemistry Pharmacology Department of Pharmacology Institute of Biological Sciences Federal University of Goiás, GoiásLaboratory of Microscopy and Microanalysis Department of Biology University Estadual Paulista – UNESP, São PauloFundação de Amparo à Pesquisa do Estado de Goiás: 02/2018CNPq: 206895/2021-8CAPES: Finance code 001Universidade Federal de Goiás (UFG)Universidade Estadual Paulista (UNESP)Gomes, Liana Silvada Silva Lima, DaniloCosta, Janaína RibeiroNaves, Jane SousaMarques, Mara RúbiaTaboga, Sebastião Roberto [UNESP]Ghedini, Paulo CésarBiancardi, Manoel FranciscoAlcantara dos Santos, Fernanda Cristina2023-07-29T13:39:50Z2023-07-29T13:39:50Z2023-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article990-1003http://dx.doi.org/10.1002/cbin.11995Cell Biology International, v. 47, n. 5, p. 990-1003, 2023.1095-83551065-6995http://hdl.handle.net/11449/24829210.1002/cbin.119952-s2.0-85147203468Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCell Biology Internationalinfo:eu-repo/semantics/openAccess2024-04-11T19:33:50Zoai:repositorio.unesp.br:11449/248292Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:19:52.407340Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia |
title |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia |
spellingShingle |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia Gomes, Liana Silva androgens endocrine disruptors estrogens female prostate metals ventral prostate |
title_short |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia |
title_full |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia |
title_fullStr |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia |
title_full_unstemmed |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia |
title_sort |
Neonatal exposure to aluminum chloride predisposes adult and senile gerbils to the prostatic hyperplasia |
author |
Gomes, Liana Silva |
author_facet |
Gomes, Liana Silva da Silva Lima, Danilo Costa, Janaína Ribeiro Naves, Jane Sousa Marques, Mara Rúbia Taboga, Sebastião Roberto [UNESP] Ghedini, Paulo César Biancardi, Manoel Francisco Alcantara dos Santos, Fernanda Cristina |
author_role |
author |
author2 |
da Silva Lima, Danilo Costa, Janaína Ribeiro Naves, Jane Sousa Marques, Mara Rúbia Taboga, Sebastião Roberto [UNESP] Ghedini, Paulo César Biancardi, Manoel Francisco Alcantara dos Santos, Fernanda Cristina |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Gomes, Liana Silva da Silva Lima, Danilo Costa, Janaína Ribeiro Naves, Jane Sousa Marques, Mara Rúbia Taboga, Sebastião Roberto [UNESP] Ghedini, Paulo César Biancardi, Manoel Francisco Alcantara dos Santos, Fernanda Cristina |
dc.subject.por.fl_str_mv |
androgens endocrine disruptors estrogens female prostate metals ventral prostate |
topic |
androgens endocrine disruptors estrogens female prostate metals ventral prostate |
description |
Several pollutants can alter neonatal prostatic development predisposing this gland to diseases. The toxicity and endocrine disrupting potential of aluminum has been reported in many organs, but little is known about its effects on the prostate. This study aimed to evaluate the effects that aluminum neonatal exposure can cause in the male ventral prostate and in the female prostate of adult and senile gerbils. Male and female pups were treated orally with aluminum chloride (10 mg/kg) from the 1st to the 14th day life. After treatment, the animals were aged until they reached 90 days or 1 year of life. The prostate glands were dissected out and submitted to morphological, immunohistochemical and ultrastructural analyses. Ventral prostates of adult males showed moderate hyperplasia and increased epithelial proliferation not associated with androgen receptor (AR) deregulation. On the other hand, senile males showed intense prostatic hyperplasia, and increased cell proliferation and epithelial AR regulation. Additionally, at both ages, there was a reduction in the prostate secretory function. The morphological changes observed in the female prostate were like those found in males. However, in adult females, prostatic hyperplasia was accompanied by a lower regulation of AR and estrogen receptor alpha, while in senile females, intense hyperplastic growth was associated with an increase in estrogen receptor alpha and a reduction in stromal AR. These results demonstrate that aluminum chloride neonatal exposure alters the hormonal regulation of the male and female prostate, inducing tissue damage that occurs in adulthood and intensifies during aging. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:39:50Z 2023-07-29T13:39:50Z 2023-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/cbin.11995 Cell Biology International, v. 47, n. 5, p. 990-1003, 2023. 1095-8355 1065-6995 http://hdl.handle.net/11449/248292 10.1002/cbin.11995 2-s2.0-85147203468 |
url |
http://dx.doi.org/10.1002/cbin.11995 http://hdl.handle.net/11449/248292 |
identifier_str_mv |
Cell Biology International, v. 47, n. 5, p. 990-1003, 2023. 1095-8355 1065-6995 10.1002/cbin.11995 2-s2.0-85147203468 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cell Biology International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
990-1003 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128497350082560 |