Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied

Detalhes bibliográficos
Autor(a) principal: Leite, C. Q F [UNESP]
Data de Publicação: 2008
Outros Autores: Sato, D. N., Higuchi, C. T. [UNESP], Sannomiya, M. [UNESP], Pavan, F. R. [UNESP], Vilegas, Wagner [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo9_p63-66.pdf
http://hdl.handle.net/11449/70794
Resumo: In this study, the antimycobacterial activity of chloroformic and methanolic extracts obtained from Byrsonima crassa leaves was evaluated. Antimycobacterial activity was assessed through the microtechnique named Microplate Alamar Blue Assay (MABA) and the promising active principles were identified by spectrophotometric analysis. The chloroformic extract presenting 62.5 μg mL-1 minimum inhibitory concentration (MIC) showed to be active against tuberculosis bacillus. The MIC value of the methanolic extract was 1000 μg mL-1. For the chloroformic one , phytochemical analysis indicated that antimycobacterial activity might be related to the presence of triterpenes.
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spelling Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa NiedAntimycobacterial activity of Byrsonima crassa Nied leaf extractsAntimycobacterial activityByrsonima crassaMABAMalpighiaceaeMycobacterium tuberculosisalpha amyrenonealpha amyrinantimycobacterial agentbeta amyrinisoniazidlupeoltriterpene derivativeunclassified drugantibacterial activityassaydrug isolationmicromethodmicroplate alamar blue assayminimum inhibitory concentrationnonhumanphytochemistryplant leafIn this study, the antimycobacterial activity of chloroformic and methanolic extracts obtained from Byrsonima crassa leaves was evaluated. Antimycobacterial activity was assessed through the microtechnique named Microplate Alamar Blue Assay (MABA) and the promising active principles were identified by spectrophotometric analysis. The chloroformic extract presenting 62.5 μg mL-1 minimum inhibitory concentration (MIC) showed to be active against tuberculosis bacillus. The MIC value of the methanolic extract was 1000 μg mL-1. For the chloroformic one , phytochemical analysis indicated that antimycobacterial activity might be related to the presence of triterpenes.Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista-UNESP, Rodovia Araraquara-Jaú Km 01, CEP: 14801-902, Araraquara/SPInstituto Adolfo Lutz Laboratório de Micobacteriologia, Rua Minas 877, CEP: 14085-410, Ribeirão Preto/SPDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista-UNESP, Rua Francisco Degni s/n, CEP: 14800-900, Araraquara/SPDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista-UNESP, Rodovia Araraquara-Jaú Km 01, CEP: 14801-902, Araraquara/SPDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista-UNESP, Rua Francisco Degni s/n, CEP: 14800-900, Araraquara/SPUniversidade Estadual Paulista (Unesp)Laboratório de MicobacteriologiaLeite, C. Q F [UNESP]Sato, D. N.Higuchi, C. T. [UNESP]Sannomiya, M. [UNESP]Pavan, F. R. [UNESP]Vilegas, Wagner [UNESP]2014-05-27T11:23:48Z2014-05-27T11:23:48Z2008-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article63-66application/pdfhttp://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo9_p63-66.pdfRevista Brasileira de Plantas Medicinais, v. 10, n. 4, p. 63-66, 2008.1516-0572http://hdl.handle.net/11449/707942-s2.0-779545207722-s2.0-77954520772.pdf0000-0003-3032-2556Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Plantas Medicinais0,199info:eu-repo/semantics/openAccess2023-10-10T06:02:55Zoai:repositorio.unesp.br:11449/70794Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-10T06:02:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
Antimycobacterial activity of Byrsonima crassa Nied leaf extracts
title Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
spellingShingle Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
Leite, C. Q F [UNESP]
Antimycobacterial activity
Byrsonima crassa
MABA
Malpighiaceae
Mycobacterium tuberculosis
alpha amyrenone
alpha amyrin
antimycobacterial agent
beta amyrin
isoniazid
lupeol
triterpene derivative
unclassified drug
antibacterial activity
assay
drug isolation
micromethod
microplate alamar blue assay
minimum inhibitory concentration
nonhuman
phytochemistry
plant leaf
title_short Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
title_full Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
title_fullStr Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
title_full_unstemmed Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
title_sort Atividade anti-micobacteriana de extratos de folhas de Byrsonima crassa Nied
author Leite, C. Q F [UNESP]
author_facet Leite, C. Q F [UNESP]
Sato, D. N.
Higuchi, C. T. [UNESP]
Sannomiya, M. [UNESP]
Pavan, F. R. [UNESP]
Vilegas, Wagner [UNESP]
author_role author
author2 Sato, D. N.
Higuchi, C. T. [UNESP]
Sannomiya, M. [UNESP]
Pavan, F. R. [UNESP]
Vilegas, Wagner [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Laboratório de Micobacteriologia
dc.contributor.author.fl_str_mv Leite, C. Q F [UNESP]
Sato, D. N.
Higuchi, C. T. [UNESP]
Sannomiya, M. [UNESP]
Pavan, F. R. [UNESP]
Vilegas, Wagner [UNESP]
dc.subject.por.fl_str_mv Antimycobacterial activity
Byrsonima crassa
MABA
Malpighiaceae
Mycobacterium tuberculosis
alpha amyrenone
alpha amyrin
antimycobacterial agent
beta amyrin
isoniazid
lupeol
triterpene derivative
unclassified drug
antibacterial activity
assay
drug isolation
micromethod
microplate alamar blue assay
minimum inhibitory concentration
nonhuman
phytochemistry
plant leaf
topic Antimycobacterial activity
Byrsonima crassa
MABA
Malpighiaceae
Mycobacterium tuberculosis
alpha amyrenone
alpha amyrin
antimycobacterial agent
beta amyrin
isoniazid
lupeol
triterpene derivative
unclassified drug
antibacterial activity
assay
drug isolation
micromethod
microplate alamar blue assay
minimum inhibitory concentration
nonhuman
phytochemistry
plant leaf
description In this study, the antimycobacterial activity of chloroformic and methanolic extracts obtained from Byrsonima crassa leaves was evaluated. Antimycobacterial activity was assessed through the microtechnique named Microplate Alamar Blue Assay (MABA) and the promising active principles were identified by spectrophotometric analysis. The chloroformic extract presenting 62.5 μg mL-1 minimum inhibitory concentration (MIC) showed to be active against tuberculosis bacillus. The MIC value of the methanolic extract was 1000 μg mL-1. For the chloroformic one , phytochemical analysis indicated that antimycobacterial activity might be related to the presence of triterpenes.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
2014-05-27T11:23:48Z
2014-05-27T11:23:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo9_p63-66.pdf
Revista Brasileira de Plantas Medicinais, v. 10, n. 4, p. 63-66, 2008.
1516-0572
http://hdl.handle.net/11449/70794
2-s2.0-77954520772
2-s2.0-77954520772.pdf
0000-0003-3032-2556
url http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo9_p63-66.pdf
http://hdl.handle.net/11449/70794
identifier_str_mv Revista Brasileira de Plantas Medicinais, v. 10, n. 4, p. 63-66, 2008.
1516-0572
2-s2.0-77954520772
2-s2.0-77954520772.pdf
0000-0003-3032-2556
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Plantas Medicinais
0,199
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 63-66
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964503094329344

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