In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/jat.3922 http://hdl.handle.net/11449/196431 |
Resumo: | Triclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (n = 8-11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post-natal day 21 and included in the study. No litter-mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre-implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring. |
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In utero and lactational exposure to triclocarban: reproductive effects on female rat offspringbehaviorendocrine disruptorfertilitymaternal exposureprogesteroneTriclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (n = 8-11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post-natal day 21 and included in the study. No litter-mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre-implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundacao AraucariaUniv Estadual Londrina, Dept Physiol Sci, Londrina, Parana, BrazilUniv Sao Paulo, Dept Morphol Estomatol & Physiol, Sao Paulo, BrazilSao Paulo State Univ, Dept Physiol, Botucatu Biosci Inst, Sao Paulo, BrazilSao Paulo State Univ, Dept Physiol, Botucatu Biosci Inst, Sao Paulo, BrazilWiley-BlackwellUniversidade Estadual de Londrina (UEL)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Costa, Nathalia OrlandiniBorges, Lorena IrenoCavalcanti, Liara FreitasMontagnini, Bruno GarciaAnselmo Franci, Janete AparecidaKiss, Ana Carolina Inhasz [UNESP]Gerardin, Daniela Cristina Ceccatto2020-12-10T19:44:43Z2020-12-10T19:44:43Z2019-12-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article504-514http://dx.doi.org/10.1002/jat.3922Journal Of Applied Toxicology. Hoboken: Wiley, v. 40, n. 4, p. 504-514, 2020.0260-437Xhttp://hdl.handle.net/11449/19643110.1002/jat.3922WOS:000503917100001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Applied Toxicologyinfo:eu-repo/semantics/openAccess2021-10-23T03:13:01Zoai:repositorio.unesp.br:11449/196431Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T03:13:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
title |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
spellingShingle |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring Costa, Nathalia Orlandini behavior endocrine disruptor fertility maternal exposure progesterone |
title_short |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
title_full |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
title_fullStr |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
title_full_unstemmed |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
title_sort |
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
author |
Costa, Nathalia Orlandini |
author_facet |
Costa, Nathalia Orlandini Borges, Lorena Ireno Cavalcanti, Liara Freitas Montagnini, Bruno Garcia Anselmo Franci, Janete Aparecida Kiss, Ana Carolina Inhasz [UNESP] Gerardin, Daniela Cristina Ceccatto |
author_role |
author |
author2 |
Borges, Lorena Ireno Cavalcanti, Liara Freitas Montagnini, Bruno Garcia Anselmo Franci, Janete Aparecida Kiss, Ana Carolina Inhasz [UNESP] Gerardin, Daniela Cristina Ceccatto |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Costa, Nathalia Orlandini Borges, Lorena Ireno Cavalcanti, Liara Freitas Montagnini, Bruno Garcia Anselmo Franci, Janete Aparecida Kiss, Ana Carolina Inhasz [UNESP] Gerardin, Daniela Cristina Ceccatto |
dc.subject.por.fl_str_mv |
behavior endocrine disruptor fertility maternal exposure progesterone |
topic |
behavior endocrine disruptor fertility maternal exposure progesterone |
description |
Triclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (n = 8-11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post-natal day 21 and included in the study. No litter-mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre-implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-23 2020-12-10T19:44:43Z 2020-12-10T19:44:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/jat.3922 Journal Of Applied Toxicology. Hoboken: Wiley, v. 40, n. 4, p. 504-514, 2020. 0260-437X http://hdl.handle.net/11449/196431 10.1002/jat.3922 WOS:000503917100001 |
url |
http://dx.doi.org/10.1002/jat.3922 http://hdl.handle.net/11449/196431 |
identifier_str_mv |
Journal Of Applied Toxicology. Hoboken: Wiley, v. 40, n. 4, p. 504-514, 2020. 0260-437X 10.1002/jat.3922 WOS:000503917100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Applied Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
504-514 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046363383988224 |