In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.reprotox.2016.04.006 http://hdl.handle.net/11449/161641 |
Resumo: | Depression is one of the most prevalent disorders in the world and may occur during pregnancy and postpartum periods. Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation. This study aimed to investigate if in utero and lactational exposure to FLX could compromise reproductive parameters in female offspring. Wistar rats received, by daily gavage, FLX 5 mg/kg or 0.3 ml of water (control group) from the first gestational day until weaning (21 days). Assessments in the female offspring included: body weight, anogenital distance, vaginal opening, first estrus, estrous cycle, reproductive organs weight, uterine morphometric analyses, ovarian follicle and corpora lutea counting, estradiol plasmatic concentration, sexual behavior, maternal behavior and fertility test. Exposure to FLX delayed the puberty onset in female pups. The present study demonstrated that developmental exposure to FLX can deregulate the neuroendocrine hormonal control of female offspring during prepubertal and pubertal periods. (C) 2016 Elsevier Inc. All rights reserved. |
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In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspringFemaleFertilityPubertyFluoxetineMaternal behaviorDepression is one of the most prevalent disorders in the world and may occur during pregnancy and postpartum periods. Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation. This study aimed to investigate if in utero and lactational exposure to FLX could compromise reproductive parameters in female offspring. Wistar rats received, by daily gavage, FLX 5 mg/kg or 0.3 ml of water (control group) from the first gestational day until weaning (21 days). Assessments in the female offspring included: body weight, anogenital distance, vaginal opening, first estrus, estrous cycle, reproductive organs weight, uterine morphometric analyses, ovarian follicle and corpora lutea counting, estradiol plasmatic concentration, sexual behavior, maternal behavior and fertility test. Exposure to FLX delayed the puberty onset in female pups. The present study demonstrated that developmental exposure to FLX can deregulate the neuroendocrine hormonal control of female offspring during prepubertal and pubertal periods. (C) 2016 Elsevier Inc. All rights reserved.Univ Estadual Londrina, Dept Physiol Sci, BR-86051980 Londrina, Parana, BrazilUniv Sao Paulo, Dept Morphol Estomatol & Physiol, Ribeirao Preto, SP, BrazilSao Paulo State Univ, Dept Physiol, Botucatu, SP, BrazilUniv Estadual Londrina, Dept Biol, BR-86051980 Londrina, Parana, BrazilSao Paulo State Univ, Dept Physiol, Botucatu, SP, BrazilElsevier B.V.Universidade Estadual de Londrina (UEL)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Santos, Alice Hartmann dosVieira, Milene LeivasCamin, Nathalia de AzevedoAnselmo-Franci, Janete AparecidaCeravolo, Graziela ScaliantiPelosi, Gislaine GarciaMoreira, Estefania GastaldelloInhasz Kiss, Ana Carolina [UNESP]Paccola Mesquita, Suzana de FatimaCeccatto Gerardin, Daniela Cristina2018-11-26T16:48:04Z2018-11-26T16:48:04Z2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-8application/pdfhttp://dx.doi.org/10.1016/j.reprotox.2016.04.006Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 62, p. 1-8, 2016.0890-6238http://hdl.handle.net/11449/16164110.1016/j.reprotox.2016.04.006WOS:000378367700001WOS000378367700001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductive Toxicology0,846info:eu-repo/semantics/openAccess2023-10-07T06:02:37Zoai:repositorio.unesp.br:11449/161641Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T11:41:40.732817Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring |
title |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring |
spellingShingle |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring Santos, Alice Hartmann dos Female Fertility Puberty Fluoxetine Maternal behavior |
title_short |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring |
title_full |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring |
title_fullStr |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring |
title_full_unstemmed |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring |
title_sort |
In utero and lactational exposure to fluoxetine delays puberty onset in female rats offspring |
author |
Santos, Alice Hartmann dos |
author_facet |
Santos, Alice Hartmann dos Vieira, Milene Leivas Camin, Nathalia de Azevedo Anselmo-Franci, Janete Aparecida Ceravolo, Graziela Scalianti Pelosi, Gislaine Garcia Moreira, Estefania Gastaldello Inhasz Kiss, Ana Carolina [UNESP] Paccola Mesquita, Suzana de Fatima Ceccatto Gerardin, Daniela Cristina |
author_role |
author |
author2 |
Vieira, Milene Leivas Camin, Nathalia de Azevedo Anselmo-Franci, Janete Aparecida Ceravolo, Graziela Scalianti Pelosi, Gislaine Garcia Moreira, Estefania Gastaldello Inhasz Kiss, Ana Carolina [UNESP] Paccola Mesquita, Suzana de Fatima Ceccatto Gerardin, Daniela Cristina |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Santos, Alice Hartmann dos Vieira, Milene Leivas Camin, Nathalia de Azevedo Anselmo-Franci, Janete Aparecida Ceravolo, Graziela Scalianti Pelosi, Gislaine Garcia Moreira, Estefania Gastaldello Inhasz Kiss, Ana Carolina [UNESP] Paccola Mesquita, Suzana de Fatima Ceccatto Gerardin, Daniela Cristina |
dc.subject.por.fl_str_mv |
Female Fertility Puberty Fluoxetine Maternal behavior |
topic |
Female Fertility Puberty Fluoxetine Maternal behavior |
description |
Depression is one of the most prevalent disorders in the world and may occur during pregnancy and postpartum periods. Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation. This study aimed to investigate if in utero and lactational exposure to FLX could compromise reproductive parameters in female offspring. Wistar rats received, by daily gavage, FLX 5 mg/kg or 0.3 ml of water (control group) from the first gestational day until weaning (21 days). Assessments in the female offspring included: body weight, anogenital distance, vaginal opening, first estrus, estrous cycle, reproductive organs weight, uterine morphometric analyses, ovarian follicle and corpora lutea counting, estradiol plasmatic concentration, sexual behavior, maternal behavior and fertility test. Exposure to FLX delayed the puberty onset in female pups. The present study demonstrated that developmental exposure to FLX can deregulate the neuroendocrine hormonal control of female offspring during prepubertal and pubertal periods. (C) 2016 Elsevier Inc. All rights reserved. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-01 2018-11-26T16:48:04Z 2018-11-26T16:48:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.reprotox.2016.04.006 Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 62, p. 1-8, 2016. 0890-6238 http://hdl.handle.net/11449/161641 10.1016/j.reprotox.2016.04.006 WOS:000378367700001 WOS000378367700001.pdf |
url |
http://dx.doi.org/10.1016/j.reprotox.2016.04.006 http://hdl.handle.net/11449/161641 |
identifier_str_mv |
Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 62, p. 1-8, 2016. 0890-6238 10.1016/j.reprotox.2016.04.006 WOS:000378367700001 WOS000378367700001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reproductive Toxicology 0,846 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-8 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803045867725258752 |