Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial

Detalhes bibliográficos
Autor(a) principal: Castro dos Santos, Nídia Cristina [UNESP]
Data de Publicação: 2016
Outros Autores: Andere, Naira Maria Rebelatto Bechara [UNESP], Araujo, Cássia Fernandes [UNESP], de Marco, Andrea Carvalho [UNESP], dos Santos, Lúcio Murilo [UNESP], Jardini, Maria Aparecida Neves [UNESP], Santamaria, Mauro Pedrine [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10103-016-2030-8
http://hdl.handle.net/11449/173290
Resumo: Diabetes has become a global epidemic. Its complications can have a significant impact on quality of life, longevity, and public health costs. The presence of diabetes might impair the prognosis of periodontal treatments due to its negative influence on wound healing. Antimicrobial photodynamic therapy (aPDT) is a local approach that can promote bacterial decontamination in periodontal pockets. The aim of this study was to investigate the local effect of adjunct aPDT to ultrasonic periodontal debridement (UPD) and compare it to UD only for the treatment of chronic periodontitis in type 2 diabetic patients. Twenty type 2 diabetic patients with moderate to severe generalized chronic periodontitis were selected. Two periodontal pockets with probing depth (PD) and clinical attachment level (CAL) ≥5 mm received UPD only (UPD group) or UPD plus adjunct aPDT (UPD + aPDT group). Periodontal clinical measures were collected and compared at baseline and 30, 90, and 180 days. After 180 days of follow-up, there were statistically significant reductions in PD from 5.75 ± 0.91 to 3.47 ± 0.97 mm in the UPD group and from 6.15 ± 1.27 to 3.71 ± 1.63 mm in the UPD + aPDT group. However, intergroup analysis did not reveal statistically significant differences in any of the evaluated clinical parameters (p > 0.05). The adjunct application of aPDT to UPD did not present additional benefits for the treatment of chronic periodontitis in type 2 diabetic patients. The ClinicalTrials.gov identifier of the present study is NCT02627534.
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spelling Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trialAntimicrobial therapyChronic periodontitisDiabetes mellitusLow-level laser therapyPeriodontal pocketPhotodynamic therapyDiabetes has become a global epidemic. Its complications can have a significant impact on quality of life, longevity, and public health costs. The presence of diabetes might impair the prognosis of periodontal treatments due to its negative influence on wound healing. Antimicrobial photodynamic therapy (aPDT) is a local approach that can promote bacterial decontamination in periodontal pockets. The aim of this study was to investigate the local effect of adjunct aPDT to ultrasonic periodontal debridement (UPD) and compare it to UD only for the treatment of chronic periodontitis in type 2 diabetic patients. Twenty type 2 diabetic patients with moderate to severe generalized chronic periodontitis were selected. Two periodontal pockets with probing depth (PD) and clinical attachment level (CAL) ≥5 mm received UPD only (UPD group) or UPD plus adjunct aPDT (UPD + aPDT group). Periodontal clinical measures were collected and compared at baseline and 30, 90, and 180 days. After 180 days of follow-up, there were statistically significant reductions in PD from 5.75 ± 0.91 to 3.47 ± 0.97 mm in the UPD group and from 6.15 ± 1.27 to 3.71 ± 1.63 mm in the UPD + aPDT group. However, intergroup analysis did not reveal statistically significant differences in any of the evaluated clinical parameters (p > 0.05). The adjunct application of aPDT to UPD did not present additional benefits for the treatment of chronic periodontitis in type 2 diabetic patients. The ClinicalTrials.gov identifier of the present study is NCT02627534.Department of Diagnosis and Surgery - Division of Periodontics College of Dentistry – FOSJC UNESP – Sao Paulo State University, Av. Eng. Francisco José Longo, 777Department of Biosciences and Oral Diagnosis College of Dentistry – FOSJC UNESP – Sao Paulo State University, Av. Eng. Francisco José Longo, 777Department of Diagnosis and Surgery - Division of Periodontics College of Dentistry – FOSJC UNESP – Sao Paulo State University, Av. Eng. Francisco José Longo, 777Department of Biosciences and Oral Diagnosis College of Dentistry – FOSJC UNESP – Sao Paulo State University, Av. Eng. Francisco José Longo, 777Universidade Estadual Paulista (Unesp)Castro dos Santos, Nídia Cristina [UNESP]Andere, Naira Maria Rebelatto Bechara [UNESP]Araujo, Cássia Fernandes [UNESP]de Marco, Andrea Carvalho [UNESP]dos Santos, Lúcio Murilo [UNESP]Jardini, Maria Aparecida Neves [UNESP]Santamaria, Mauro Pedrine [UNESP]2018-12-11T17:04:31Z2018-12-11T17:04:31Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1633-1640application/pdfhttp://dx.doi.org/10.1007/s10103-016-2030-8Lasers in Medical Science, v. 31, n. 8, p. 1633-1640, 2016.1435-604X0268-8921http://hdl.handle.net/11449/17329010.1007/s10103-016-2030-82-s2.0-849792875032-s2.0-84979287503.pdf57336393420169587008114923397947Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLasers in Medical Science0,713info:eu-repo/semantics/openAccess2023-11-19T06:11:50Zoai:repositorio.unesp.br:11449/173290Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:08:04.754287Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
title Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
spellingShingle Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
Castro dos Santos, Nídia Cristina [UNESP]
Antimicrobial therapy
Chronic periodontitis
Diabetes mellitus
Low-level laser therapy
Periodontal pocket
Photodynamic therapy
title_short Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
title_full Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
title_fullStr Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
title_full_unstemmed Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
title_sort Local adjunct effect of antimicrobial photodynamic therapy for the treatment of chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized controlled clinical trial
author Castro dos Santos, Nídia Cristina [UNESP]
author_facet Castro dos Santos, Nídia Cristina [UNESP]
Andere, Naira Maria Rebelatto Bechara [UNESP]
Araujo, Cássia Fernandes [UNESP]
de Marco, Andrea Carvalho [UNESP]
dos Santos, Lúcio Murilo [UNESP]
Jardini, Maria Aparecida Neves [UNESP]
Santamaria, Mauro Pedrine [UNESP]
author_role author
author2 Andere, Naira Maria Rebelatto Bechara [UNESP]
Araujo, Cássia Fernandes [UNESP]
de Marco, Andrea Carvalho [UNESP]
dos Santos, Lúcio Murilo [UNESP]
Jardini, Maria Aparecida Neves [UNESP]
Santamaria, Mauro Pedrine [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Castro dos Santos, Nídia Cristina [UNESP]
Andere, Naira Maria Rebelatto Bechara [UNESP]
Araujo, Cássia Fernandes [UNESP]
de Marco, Andrea Carvalho [UNESP]
dos Santos, Lúcio Murilo [UNESP]
Jardini, Maria Aparecida Neves [UNESP]
Santamaria, Mauro Pedrine [UNESP]
dc.subject.por.fl_str_mv Antimicrobial therapy
Chronic periodontitis
Diabetes mellitus
Low-level laser therapy
Periodontal pocket
Photodynamic therapy
topic Antimicrobial therapy
Chronic periodontitis
Diabetes mellitus
Low-level laser therapy
Periodontal pocket
Photodynamic therapy
description Diabetes has become a global epidemic. Its complications can have a significant impact on quality of life, longevity, and public health costs. The presence of diabetes might impair the prognosis of periodontal treatments due to its negative influence on wound healing. Antimicrobial photodynamic therapy (aPDT) is a local approach that can promote bacterial decontamination in periodontal pockets. The aim of this study was to investigate the local effect of adjunct aPDT to ultrasonic periodontal debridement (UPD) and compare it to UD only for the treatment of chronic periodontitis in type 2 diabetic patients. Twenty type 2 diabetic patients with moderate to severe generalized chronic periodontitis were selected. Two periodontal pockets with probing depth (PD) and clinical attachment level (CAL) ≥5 mm received UPD only (UPD group) or UPD plus adjunct aPDT (UPD + aPDT group). Periodontal clinical measures were collected and compared at baseline and 30, 90, and 180 days. After 180 days of follow-up, there were statistically significant reductions in PD from 5.75 ± 0.91 to 3.47 ± 0.97 mm in the UPD group and from 6.15 ± 1.27 to 3.71 ± 1.63 mm in the UPD + aPDT group. However, intergroup analysis did not reveal statistically significant differences in any of the evaluated clinical parameters (p > 0.05). The adjunct application of aPDT to UPD did not present additional benefits for the treatment of chronic periodontitis in type 2 diabetic patients. The ClinicalTrials.gov identifier of the present study is NCT02627534.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-01
2018-12-11T17:04:31Z
2018-12-11T17:04:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10103-016-2030-8
Lasers in Medical Science, v. 31, n. 8, p. 1633-1640, 2016.
1435-604X
0268-8921
http://hdl.handle.net/11449/173290
10.1007/s10103-016-2030-8
2-s2.0-84979287503
2-s2.0-84979287503.pdf
5733639342016958
7008114923397947
url http://dx.doi.org/10.1007/s10103-016-2030-8
http://hdl.handle.net/11449/173290
identifier_str_mv Lasers in Medical Science, v. 31, n. 8, p. 1633-1640, 2016.
1435-604X
0268-8921
10.1007/s10103-016-2030-8
2-s2.0-84979287503
2-s2.0-84979287503.pdf
5733639342016958
7008114923397947
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lasers in Medical Science
0,713
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dc.format.none.fl_str_mv 1633-1640
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
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instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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