Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.appet.2022.106014 http://hdl.handle.net/11449/230688 |
Resumo: | Sodium appetite reverts from aversive to hedonic the orofacial responses to intraoral hypertonic NaCl in a taste reactivity test (TRT). An electrophysiological-based hypothesis suggests that aversion to salty taste results from oral nociception (e.g., like that produced by intraoral capsaicin). In the present work, we used the TRT to investigate whether sodium appetite and its sensitization produce similar effects on the orofacial responses to the intraoral infusion of either capsaicin or hypertonic NaCl. We produced rapid onset sodium appetite by subcutaneous injection of furosemide combined with a low dose of captopril (Furo/Cap) in adult rats instrumented with intraoral cannula. Then, the animals had 1-h free access to water (thirst test). Immediately after, they entered the TRT receiving a first intraoral infusion (1 ml for a total of 1 min) of (0.5 μM) capsaicin and, 20 min later, a second one of (0.3 M) NaCl. The sequence, Furo/Cap injection - thirst test - TRT, was repeated twice more every three days. The repetition of the Furo/Cap increased the frequency of hedonic responses, decreased the frequency of aversive responses, and increased the hedonic:neutral response ratio to NaCl. The repetition of Furo/Cap reduced transiently the neutral orofacial responses and ended decreasing the aversive:neutral response ratio to capsaicin. The results suggest that repeated Furo/Cap sensitizes the palatability of hypertonic NaCl. They also suggest that sensitization of sodium appetite involves increased sodium “liking”. Finally yet importantly, we found that sensitization of sodium appetite can influence orofacial responses to capsaicin. Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat. |
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Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the ratEmotionOral nociceptionSalt intakeTaste“Liking”Sodium appetite reverts from aversive to hedonic the orofacial responses to intraoral hypertonic NaCl in a taste reactivity test (TRT). An electrophysiological-based hypothesis suggests that aversion to salty taste results from oral nociception (e.g., like that produced by intraoral capsaicin). In the present work, we used the TRT to investigate whether sodium appetite and its sensitization produce similar effects on the orofacial responses to the intraoral infusion of either capsaicin or hypertonic NaCl. We produced rapid onset sodium appetite by subcutaneous injection of furosemide combined with a low dose of captopril (Furo/Cap) in adult rats instrumented with intraoral cannula. Then, the animals had 1-h free access to water (thirst test). Immediately after, they entered the TRT receiving a first intraoral infusion (1 ml for a total of 1 min) of (0.5 μM) capsaicin and, 20 min later, a second one of (0.3 M) NaCl. The sequence, Furo/Cap injection - thirst test - TRT, was repeated twice more every three days. The repetition of the Furo/Cap increased the frequency of hedonic responses, decreased the frequency of aversive responses, and increased the hedonic:neutral response ratio to NaCl. The repetition of Furo/Cap reduced transiently the neutral orofacial responses and ended decreasing the aversive:neutral response ratio to capsaicin. The results suggest that repeated Furo/Cap sensitizes the palatability of hypertonic NaCl. They also suggest that sensitization of sodium appetite involves increased sodium “liking”. Finally yet importantly, we found that sensitization of sodium appetite can influence orofacial responses to capsaicin. Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)National Research CouncilCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Physiology and Pathology School of Dentistry - FOAr São Paulo State University UNESP, SPDepartment of Physiology and Pathology School of Dentistry - FOAr São Paulo State University UNESP, SPCAPES: 001FAPESP: 2011/50770-1FAPESP: 2015/20500-3CNPq: 301939/2013-6CNPq: 306833/2021-2CNPq: 310216/2017-6CNPq: 478960/2013-1Universidade Estadual Paulista (UNESP)Fernandes, Natalie Aparecida Rodrigues [UNESP]Santos, Bruna Maitan [UNESP]Andrade-Franzé, Gláucia Maria Fabrício de [UNESP]de Paula, Patrícia Maria [UNESP]Andrade, Carina Aparecida Fabrício de [UNESP]Vanderlei Menani, José [UNESP]De Luca, Laurival Antonio [UNESP]2022-04-29T08:41:31Z2022-04-29T08:41:31Z2022-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.appet.2022.106014Appetite, v. 174.1095-83040195-6663http://hdl.handle.net/11449/23068810.1016/j.appet.2022.1060142-s2.0-85127745938Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAppetiteinfo:eu-repo/semantics/openAccess2022-04-29T08:41:31Zoai:repositorio.unesp.br:11449/230688Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:13:04.242689Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat |
title |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat |
spellingShingle |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat Fernandes, Natalie Aparecida Rodrigues [UNESP] Emotion Oral nociception Salt intake Taste “Liking” |
title_short |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat |
title_full |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat |
title_fullStr |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat |
title_full_unstemmed |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat |
title_sort |
Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat |
author |
Fernandes, Natalie Aparecida Rodrigues [UNESP] |
author_facet |
Fernandes, Natalie Aparecida Rodrigues [UNESP] Santos, Bruna Maitan [UNESP] Andrade-Franzé, Gláucia Maria Fabrício de [UNESP] de Paula, Patrícia Maria [UNESP] Andrade, Carina Aparecida Fabrício de [UNESP] Vanderlei Menani, José [UNESP] De Luca, Laurival Antonio [UNESP] |
author_role |
author |
author2 |
Santos, Bruna Maitan [UNESP] Andrade-Franzé, Gláucia Maria Fabrício de [UNESP] de Paula, Patrícia Maria [UNESP] Andrade, Carina Aparecida Fabrício de [UNESP] Vanderlei Menani, José [UNESP] De Luca, Laurival Antonio [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Fernandes, Natalie Aparecida Rodrigues [UNESP] Santos, Bruna Maitan [UNESP] Andrade-Franzé, Gláucia Maria Fabrício de [UNESP] de Paula, Patrícia Maria [UNESP] Andrade, Carina Aparecida Fabrício de [UNESP] Vanderlei Menani, José [UNESP] De Luca, Laurival Antonio [UNESP] |
dc.subject.por.fl_str_mv |
Emotion Oral nociception Salt intake Taste “Liking” |
topic |
Emotion Oral nociception Salt intake Taste “Liking” |
description |
Sodium appetite reverts from aversive to hedonic the orofacial responses to intraoral hypertonic NaCl in a taste reactivity test (TRT). An electrophysiological-based hypothesis suggests that aversion to salty taste results from oral nociception (e.g., like that produced by intraoral capsaicin). In the present work, we used the TRT to investigate whether sodium appetite and its sensitization produce similar effects on the orofacial responses to the intraoral infusion of either capsaicin or hypertonic NaCl. We produced rapid onset sodium appetite by subcutaneous injection of furosemide combined with a low dose of captopril (Furo/Cap) in adult rats instrumented with intraoral cannula. Then, the animals had 1-h free access to water (thirst test). Immediately after, they entered the TRT receiving a first intraoral infusion (1 ml for a total of 1 min) of (0.5 μM) capsaicin and, 20 min later, a second one of (0.3 M) NaCl. The sequence, Furo/Cap injection - thirst test - TRT, was repeated twice more every three days. The repetition of the Furo/Cap increased the frequency of hedonic responses, decreased the frequency of aversive responses, and increased the hedonic:neutral response ratio to NaCl. The repetition of Furo/Cap reduced transiently the neutral orofacial responses and ended decreasing the aversive:neutral response ratio to capsaicin. The results suggest that repeated Furo/Cap sensitizes the palatability of hypertonic NaCl. They also suggest that sensitization of sodium appetite involves increased sodium “liking”. Finally yet importantly, we found that sensitization of sodium appetite can influence orofacial responses to capsaicin. Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:41:31Z 2022-04-29T08:41:31Z 2022-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.appet.2022.106014 Appetite, v. 174. 1095-8304 0195-6663 http://hdl.handle.net/11449/230688 10.1016/j.appet.2022.106014 2-s2.0-85127745938 |
url |
http://dx.doi.org/10.1016/j.appet.2022.106014 http://hdl.handle.net/11449/230688 |
identifier_str_mv |
Appetite, v. 174. 1095-8304 0195-6663 10.1016/j.appet.2022.106014 2-s2.0-85127745938 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Appetite |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129500090728448 |