Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1177/0885066617710218 http://hdl.handle.net/11449/188083 |
Resumo: | Background: The objective of our study was to evaluate the association of serum malondialdehyde (MDA) and protein carbonyl concentration with intensive care unit (ICU) mortality in patients with septic shock. Methods: We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 16 patients were excluded. Thus, 159 patients were enrolled in the study. In addition, we evaluated 16 control patients. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient’s admission to determine serum MDA and protein carbonyl concentrations. Results: The mean age was 67.3 ± 15.9 years, 44% were males, and the ICU mortality rate was 67.9%. Median MDA concentration was 1.53 (0.83-2.22) µmol/L, and median protein carbonyl concentration was 24.0 (12.7-32.8) nmol/mL. Patients who died during ICU stay had higher protein carbonyl concentration. However, there was no difference in MDA levels between these patients. Receiver operating characteristic curve analysis showed that higher levels of protein carbonyl were associated with ICU mortality (area under the curve: 0.955; 95% confidence interval [CI]: 0.918-0.992; P <.001) at the cutoff of >22.83 nmol/mL (sensibility: 80.4% and specificity: 98.1%). In the logistic regression models, protein carbonyl concentrations (odds ratio [OR]: 1.424; 95% CI: 1.268-1.600; P <.001), but not MDA concentrations (OR: 1.087; 95% CI: 0.805-1.467; P =.59), were associated with ICU mortality when adjusted for age, gender, and Acute Physiology and Chronic Health Evaluation (APACHE) II score; and when adjusted by APACHE II score, lactate, and urea; protein carbonyl concentrations (OR: 1.394; 95% CI: 1.242-1.564; P <.001); and MDA (OR: 1.054; 95% CI: 0.776-1.432; P =.73). Conclusion: In conclusion, protein carbonyl, but not MDA, concentration is associated with ICU mortality in patients with septic shock. |
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Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shockmalondialdehydeoxidative stressprotein carbonylsepsisshockBackground: The objective of our study was to evaluate the association of serum malondialdehyde (MDA) and protein carbonyl concentration with intensive care unit (ICU) mortality in patients with septic shock. Methods: We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 16 patients were excluded. Thus, 159 patients were enrolled in the study. In addition, we evaluated 16 control patients. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient’s admission to determine serum MDA and protein carbonyl concentrations. Results: The mean age was 67.3 ± 15.9 years, 44% were males, and the ICU mortality rate was 67.9%. Median MDA concentration was 1.53 (0.83-2.22) µmol/L, and median protein carbonyl concentration was 24.0 (12.7-32.8) nmol/mL. Patients who died during ICU stay had higher protein carbonyl concentration. However, there was no difference in MDA levels between these patients. Receiver operating characteristic curve analysis showed that higher levels of protein carbonyl were associated with ICU mortality (area under the curve: 0.955; 95% confidence interval [CI]: 0.918-0.992; P <.001) at the cutoff of >22.83 nmol/mL (sensibility: 80.4% and specificity: 98.1%). In the logistic regression models, protein carbonyl concentrations (odds ratio [OR]: 1.424; 95% CI: 1.268-1.600; P <.001), but not MDA concentrations (OR: 1.087; 95% CI: 0.805-1.467; P =.59), were associated with ICU mortality when adjusted for age, gender, and Acute Physiology and Chronic Health Evaluation (APACHE) II score; and when adjusted by APACHE II score, lactate, and urea; protein carbonyl concentrations (OR: 1.394; 95% CI: 1.242-1.564; P <.001); and MDA (OR: 1.054; 95% CI: 0.776-1.432; P =.73). Conclusion: In conclusion, protein carbonyl, but not MDA, concentration is associated with ICU mortality in patients with septic shock.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of Internal Medicine Botucatu Medical School Universidade Estadual Paulista (UNESP)Department of Chemistry and Biochemistry Institute of Biological Sciences Universidade Estadual Paulista (UNESP)Department of Internal Medicine Botucatu Medical School Universidade Estadual Paulista (UNESP)Department of Chemistry and Biochemistry Institute of Biological Sciences Universidade Estadual Paulista (UNESP)CAPES: 2014/17262-0Universidade Estadual Paulista (Unesp)Costa, Nara Aline [UNESP]Gut, Ana Lucia [UNESP]Azevedo, Paula Schmidt [UNESP]Fernandes, Ana Angelica Henrique [UNESP]Polegato, Bertha Furlan [UNESP]Cunha, Natália Baraldi [UNESP]Bachiega, Tatiana Fernanda [UNESP]Lourenço, Maria Angélica Martins [UNESP]Júnior, Edson Luiz Favero [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]de Paiva, Sergio Alberto Rupp [UNESP]Minicucci, Marcos Ferreira [UNESP]2019-10-06T15:56:44Z2019-10-06T15:56:44Z2019-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article669-673http://dx.doi.org/10.1177/0885066617710218Journal of Intensive Care Medicine, v. 34, n. 8, p. 669-673, 2019.1525-14890885-0666http://hdl.handle.net/11449/18808310.1177/08850666177102182-s2.0-850411712385016839015394547121314080140264774387040344716730000-0002-5843-6232Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Intensive Care Medicineinfo:eu-repo/semantics/openAccess2021-10-23T21:47:17Zoai:repositorio.unesp.br:11449/188083Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T21:47:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock |
title |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock |
spellingShingle |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock Costa, Nara Aline [UNESP] malondialdehyde oxidative stress protein carbonyl sepsis shock |
title_short |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock |
title_full |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock |
title_fullStr |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock |
title_full_unstemmed |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock |
title_sort |
Protein Carbonyl, But Not Malondialdehyde, Is Associated With ICU Mortality in Patients With Septic Shock |
author |
Costa, Nara Aline [UNESP] |
author_facet |
Costa, Nara Aline [UNESP] Gut, Ana Lucia [UNESP] Azevedo, Paula Schmidt [UNESP] Fernandes, Ana Angelica Henrique [UNESP] Polegato, Bertha Furlan [UNESP] Cunha, Natália Baraldi [UNESP] Bachiega, Tatiana Fernanda [UNESP] Lourenço, Maria Angélica Martins [UNESP] Júnior, Edson Luiz Favero [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author_role |
author |
author2 |
Gut, Ana Lucia [UNESP] Azevedo, Paula Schmidt [UNESP] Fernandes, Ana Angelica Henrique [UNESP] Polegato, Bertha Furlan [UNESP] Cunha, Natália Baraldi [UNESP] Bachiega, Tatiana Fernanda [UNESP] Lourenço, Maria Angélica Martins [UNESP] Júnior, Edson Luiz Favero [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Costa, Nara Aline [UNESP] Gut, Ana Lucia [UNESP] Azevedo, Paula Schmidt [UNESP] Fernandes, Ana Angelica Henrique [UNESP] Polegato, Bertha Furlan [UNESP] Cunha, Natália Baraldi [UNESP] Bachiega, Tatiana Fernanda [UNESP] Lourenço, Maria Angélica Martins [UNESP] Júnior, Edson Luiz Favero [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] de Paiva, Sergio Alberto Rupp [UNESP] Minicucci, Marcos Ferreira [UNESP] |
dc.subject.por.fl_str_mv |
malondialdehyde oxidative stress protein carbonyl sepsis shock |
topic |
malondialdehyde oxidative stress protein carbonyl sepsis shock |
description |
Background: The objective of our study was to evaluate the association of serum malondialdehyde (MDA) and protein carbonyl concentration with intensive care unit (ICU) mortality in patients with septic shock. Methods: We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 16 patients were excluded. Thus, 159 patients were enrolled in the study. In addition, we evaluated 16 control patients. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient’s admission to determine serum MDA and protein carbonyl concentrations. Results: The mean age was 67.3 ± 15.9 years, 44% were males, and the ICU mortality rate was 67.9%. Median MDA concentration was 1.53 (0.83-2.22) µmol/L, and median protein carbonyl concentration was 24.0 (12.7-32.8) nmol/mL. Patients who died during ICU stay had higher protein carbonyl concentration. However, there was no difference in MDA levels between these patients. Receiver operating characteristic curve analysis showed that higher levels of protein carbonyl were associated with ICU mortality (area under the curve: 0.955; 95% confidence interval [CI]: 0.918-0.992; P <.001) at the cutoff of >22.83 nmol/mL (sensibility: 80.4% and specificity: 98.1%). In the logistic regression models, protein carbonyl concentrations (odds ratio [OR]: 1.424; 95% CI: 1.268-1.600; P <.001), but not MDA concentrations (OR: 1.087; 95% CI: 0.805-1.467; P =.59), were associated with ICU mortality when adjusted for age, gender, and Acute Physiology and Chronic Health Evaluation (APACHE) II score; and when adjusted by APACHE II score, lactate, and urea; protein carbonyl concentrations (OR: 1.394; 95% CI: 1.242-1.564; P <.001); and MDA (OR: 1.054; 95% CI: 0.776-1.432; P =.73). Conclusion: In conclusion, protein carbonyl, but not MDA, concentration is associated with ICU mortality in patients with septic shock. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T15:56:44Z 2019-10-06T15:56:44Z 2019-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1177/0885066617710218 Journal of Intensive Care Medicine, v. 34, n. 8, p. 669-673, 2019. 1525-1489 0885-0666 http://hdl.handle.net/11449/188083 10.1177/0885066617710218 2-s2.0-85041171238 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
url |
http://dx.doi.org/10.1177/0885066617710218 http://hdl.handle.net/11449/188083 |
identifier_str_mv |
Journal of Intensive Care Medicine, v. 34, n. 8, p. 669-673, 2019. 1525-1489 0885-0666 10.1177/0885066617710218 2-s2.0-85041171238 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Intensive Care Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
669-673 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965069496287232 |