Natural products isolated from oriental medicinal herbs inactivate zika virus
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/v11010049 http://hdl.handle.net/11449/190049 |
Resumo: | Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus. |
id |
UNSP_26721ae5a0699d96108b0b29b8d59121 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/190049 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Natural products isolated from oriental medicinal herbs inactivate zika virusBerberinEmodinVero E6 cellsZIKVZika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.Laboratory of Genomic Studies Sao Paulo State University—UNESPDepartamento de Doenças Infecciosas e Parasitárias FAMERP Institute of Exact and Natural Science Mato Grosso Federal UniversityDepartment of Physics Multiuser Center for Biomolecular Innovation Sao Paulo State University-UNESPLaboratory of Genomic Studies Sao Paulo State University—UNESPDepartment of Physics Multiuser Center for Biomolecular Innovation Sao Paulo State University-UNESPUniversidade Estadual Paulista (Unesp)Mato Grosso Federal UniversityBatista, Mariana N. [UNESP]Braga, Ana Cláudia S. [UNESP]Fernandes Campos, Guilherme Rodrigues [UNESP]Michel Souza, Marcos [UNESP]de Matos, Renata Prandini Adum [UNESP]Zara Lopes, Tairine [UNESP]Maria Candido, Natalia [UNESP]Duarte Lima, Maria Leticia [UNESP]Cristina Machado, Francielly [UNESP]de Andrade, Stephane Tereza Queiroz [UNESP]Bittar, Cíntia [UNESP]Nogueira, Maurício L.Carneiro, Bruno M. [UNESP]Mariutti, Ricardo B. [UNESP]Krishnaswamy Arni, Raghuvir [UNESP]Freitas Calmon, Marilia [UNESP]Rahal, Paula [UNESP]2019-10-06T17:00:37Z2019-10-06T17:00:37Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/v11010049Viruses, v. 11, n. 1, 2019.1999-4915http://hdl.handle.net/11449/19004910.3390/v110100492-s2.0-8506005877079910823626712120000-0001-5693-6148Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirusesinfo:eu-repo/semantics/openAccess2021-10-23T03:22:20Zoai:repositorio.unesp.br:11449/190049Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:37:51.785215Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Natural products isolated from oriental medicinal herbs inactivate zika virus |
title |
Natural products isolated from oriental medicinal herbs inactivate zika virus |
spellingShingle |
Natural products isolated from oriental medicinal herbs inactivate zika virus Batista, Mariana N. [UNESP] Berberin Emodin Vero E6 cells ZIKV |
title_short |
Natural products isolated from oriental medicinal herbs inactivate zika virus |
title_full |
Natural products isolated from oriental medicinal herbs inactivate zika virus |
title_fullStr |
Natural products isolated from oriental medicinal herbs inactivate zika virus |
title_full_unstemmed |
Natural products isolated from oriental medicinal herbs inactivate zika virus |
title_sort |
Natural products isolated from oriental medicinal herbs inactivate zika virus |
author |
Batista, Mariana N. [UNESP] |
author_facet |
Batista, Mariana N. [UNESP] Braga, Ana Cláudia S. [UNESP] Fernandes Campos, Guilherme Rodrigues [UNESP] Michel Souza, Marcos [UNESP] de Matos, Renata Prandini Adum [UNESP] Zara Lopes, Tairine [UNESP] Maria Candido, Natalia [UNESP] Duarte Lima, Maria Leticia [UNESP] Cristina Machado, Francielly [UNESP] de Andrade, Stephane Tereza Queiroz [UNESP] Bittar, Cíntia [UNESP] Nogueira, Maurício L. Carneiro, Bruno M. [UNESP] Mariutti, Ricardo B. [UNESP] Krishnaswamy Arni, Raghuvir [UNESP] Freitas Calmon, Marilia [UNESP] Rahal, Paula [UNESP] |
author_role |
author |
author2 |
Braga, Ana Cláudia S. [UNESP] Fernandes Campos, Guilherme Rodrigues [UNESP] Michel Souza, Marcos [UNESP] de Matos, Renata Prandini Adum [UNESP] Zara Lopes, Tairine [UNESP] Maria Candido, Natalia [UNESP] Duarte Lima, Maria Leticia [UNESP] Cristina Machado, Francielly [UNESP] de Andrade, Stephane Tereza Queiroz [UNESP] Bittar, Cíntia [UNESP] Nogueira, Maurício L. Carneiro, Bruno M. [UNESP] Mariutti, Ricardo B. [UNESP] Krishnaswamy Arni, Raghuvir [UNESP] Freitas Calmon, Marilia [UNESP] Rahal, Paula [UNESP] |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Mato Grosso Federal University |
dc.contributor.author.fl_str_mv |
Batista, Mariana N. [UNESP] Braga, Ana Cláudia S. [UNESP] Fernandes Campos, Guilherme Rodrigues [UNESP] Michel Souza, Marcos [UNESP] de Matos, Renata Prandini Adum [UNESP] Zara Lopes, Tairine [UNESP] Maria Candido, Natalia [UNESP] Duarte Lima, Maria Leticia [UNESP] Cristina Machado, Francielly [UNESP] de Andrade, Stephane Tereza Queiroz [UNESP] Bittar, Cíntia [UNESP] Nogueira, Maurício L. Carneiro, Bruno M. [UNESP] Mariutti, Ricardo B. [UNESP] Krishnaswamy Arni, Raghuvir [UNESP] Freitas Calmon, Marilia [UNESP] Rahal, Paula [UNESP] |
dc.subject.por.fl_str_mv |
Berberin Emodin Vero E6 cells ZIKV |
topic |
Berberin Emodin Vero E6 cells ZIKV |
description |
Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:00:37Z 2019-10-06T17:00:37Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/v11010049 Viruses, v. 11, n. 1, 2019. 1999-4915 http://hdl.handle.net/11449/190049 10.3390/v11010049 2-s2.0-85060058770 7991082362671212 0000-0001-5693-6148 |
url |
http://dx.doi.org/10.3390/v11010049 http://hdl.handle.net/11449/190049 |
identifier_str_mv |
Viruses, v. 11, n. 1, 2019. 1999-4915 10.3390/v11010049 2-s2.0-85060058770 7991082362671212 0000-0001-5693-6148 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Viruses |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128680763850752 |