Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1414-431x20198969 http://hdl.handle.net/11449/231439 |
Resumo: | This study investigated the repercussions of adjuvant-induced arthritis (AIA) on body composition and the structural organization of the soleus and cardiac muscles, including their vascularization, at different times of disease manifestation. Male rats were submitted to AIA induction by intradermal administration of 100 mL ofMycobacterium tuberculosis (50 mg/mL), in the right hind paw. Animals submitted to AIA were studied 4 (AIA4), 15 (AIA15), and 40 (AIA40) days after AIA induction as well as a control group of animals not submitted to AIA. Unlike the control animals, AIA animals did not gain body mass throughout the evolution of the disease. AIA reduced food consumption, but only on the 40th day after induction. In the soleus muscle, AIA reduced the wet mass in a time-dependent manner but increased the capillary density by the 15th day and the fiber density by both 15 and 40 days after induction. The diameter of the soleus fiber decreased from the 4th day after AIA induction as well as the capillary/fiber ratio, which was most evident on the 40th day. Moreover, AIA induced slight histopathological changes in the cardiac muscle that were more evident on the 15th day after induction. In conclusion, AIA-induced changes in body composition as well as in the soleus muscle fibers and vasculature have early onset but are more evident by the 15th day after induction. Moreover, the heart may be a target organ of AIA, although less sensitive than skeletal muscles. |
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Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of ratsBody compositionCachexiaCardiovascularExperimental arthritisMicrocirculationMusculoskeletalThis study investigated the repercussions of adjuvant-induced arthritis (AIA) on body composition and the structural organization of the soleus and cardiac muscles, including their vascularization, at different times of disease manifestation. Male rats were submitted to AIA induction by intradermal administration of 100 mL ofMycobacterium tuberculosis (50 mg/mL), in the right hind paw. Animals submitted to AIA were studied 4 (AIA4), 15 (AIA15), and 40 (AIA40) days after AIA induction as well as a control group of animals not submitted to AIA. Unlike the control animals, AIA animals did not gain body mass throughout the evolution of the disease. AIA reduced food consumption, but only on the 40th day after induction. In the soleus muscle, AIA reduced the wet mass in a time-dependent manner but increased the capillary density by the 15th day and the fiber density by both 15 and 40 days after induction. The diameter of the soleus fiber decreased from the 4th day after AIA induction as well as the capillary/fiber ratio, which was most evident on the 40th day. Moreover, AIA induced slight histopathological changes in the cardiac muscle that were more evident on the 15th day after induction. In conclusion, AIA-induced changes in body composition as well as in the soleus muscle fibers and vasculature have early onset but are more evident by the 15th day after induction. Moreover, the heart may be a target organ of AIA, although less sensitive than skeletal muscles.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratório de Farmacologia Faculdade de Medicina de MaríliaLaboratório de Embriologia Humana Faculdade de Medicina de MaríliaDepartamento de Farmacologia Instituto de Biociências de BotucatuCAPES: 1768591FAPESP: 2016/08450-3FAPESP: 2017/ 00746-3Faculdade de Medicina de MaríliaInstituto de Biociências de BotucatuPita, L. M.Spadella, M. A.Montenote, M. C.Oliveira, P. B.Chies, A. B.2022-04-29T08:45:26Z2022-04-29T08:45:26Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/1414-431x20198969Brazilian Journal of Medical and Biological Research, v. 53, n. 3, 2020.1678-45100100-879Xhttp://hdl.handle.net/11449/23143910.1590/1414-431x201989692-s2.0-85081042543Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccess2022-04-29T08:45:26Zoai:repositorio.unesp.br:11449/231439Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:58:11.220528Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats |
title |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats |
spellingShingle |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats Pita, L. M. Body composition Cachexia Cardiovascular Experimental arthritis Microcirculation Musculoskeletal |
title_short |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats |
title_full |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats |
title_fullStr |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats |
title_full_unstemmed |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats |
title_sort |
Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats |
author |
Pita, L. M. |
author_facet |
Pita, L. M. Spadella, M. A. Montenote, M. C. Oliveira, P. B. Chies, A. B. |
author_role |
author |
author2 |
Spadella, M. A. Montenote, M. C. Oliveira, P. B. Chies, A. B. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina de Marília Instituto de Biociências de Botucatu |
dc.contributor.author.fl_str_mv |
Pita, L. M. Spadella, M. A. Montenote, M. C. Oliveira, P. B. Chies, A. B. |
dc.subject.por.fl_str_mv |
Body composition Cachexia Cardiovascular Experimental arthritis Microcirculation Musculoskeletal |
topic |
Body composition Cachexia Cardiovascular Experimental arthritis Microcirculation Musculoskeletal |
description |
This study investigated the repercussions of adjuvant-induced arthritis (AIA) on body composition and the structural organization of the soleus and cardiac muscles, including their vascularization, at different times of disease manifestation. Male rats were submitted to AIA induction by intradermal administration of 100 mL ofMycobacterium tuberculosis (50 mg/mL), in the right hind paw. Animals submitted to AIA were studied 4 (AIA4), 15 (AIA15), and 40 (AIA40) days after AIA induction as well as a control group of animals not submitted to AIA. Unlike the control animals, AIA animals did not gain body mass throughout the evolution of the disease. AIA reduced food consumption, but only on the 40th day after induction. In the soleus muscle, AIA reduced the wet mass in a time-dependent manner but increased the capillary density by the 15th day and the fiber density by both 15 and 40 days after induction. The diameter of the soleus fiber decreased from the 4th day after AIA induction as well as the capillary/fiber ratio, which was most evident on the 40th day. Moreover, AIA induced slight histopathological changes in the cardiac muscle that were more evident on the 15th day after induction. In conclusion, AIA-induced changes in body composition as well as in the soleus muscle fibers and vasculature have early onset but are more evident by the 15th day after induction. Moreover, the heart may be a target organ of AIA, although less sensitive than skeletal muscles. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 2022-04-29T08:45:26Z 2022-04-29T08:45:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1414-431x20198969 Brazilian Journal of Medical and Biological Research, v. 53, n. 3, 2020. 1678-4510 0100-879X http://hdl.handle.net/11449/231439 10.1590/1414-431x20198969 2-s2.0-85081042543 |
url |
http://dx.doi.org/10.1590/1414-431x20198969 http://hdl.handle.net/11449/231439 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research, v. 53, n. 3, 2020. 1678-4510 0100-879X 10.1590/1414-431x20198969 2-s2.0-85081042543 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129568003850240 |