Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125836 http://hdl.handle.net/11449/128601 |
Resumo: | Experimental autoimmune encephalomyelitis (EAE) is an animal model to study multiple sclerosis (MS). Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte glycoprotein (MOG) associated with active vitamin D in EAE development. EAE was induced in female C57BL/6 mice by immunization with MOG emulsified with Complete Freund's Adjuvant plus Mycobacterium tuberculosis. Animals also received two intraperitoneal doses of Bordetella pertussis toxin. One day after immunization, mice were treated with 0,1 mu g of 1 alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) every other day during 15 days (on days 1, 3, 5, 7, 9, 11, 13 and 15). MOG (150 mu g) was coadministered on days 3 and 11. The administration of 1,25(OH)(2)D-3 or MOG determined significant reduction in EAE incidence and in clinical scores. When MOG was associated with 1,25(OH)(2)D-3 the animals did not develop EAE. Spleen and central nervous system (CNS) cell cultures from this group produced less IL-6 and IL-17 upon stimulation with MOG in comparison to the EAE control group. In addition, this treatment inhibited dendritic cells maturation in the spleen and reduced inflammatory infiltration in the CNS. The association of MOG with 1,25(OH)(2)D-3 was able to control EAE development. |
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Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitisExperimental autoimmune encephalomyelitis (EAE) is an animal model to study multiple sclerosis (MS). Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte glycoprotein (MOG) associated with active vitamin D in EAE development. EAE was induced in female C57BL/6 mice by immunization with MOG emulsified with Complete Freund's Adjuvant plus Mycobacterium tuberculosis. Animals also received two intraperitoneal doses of Bordetella pertussis toxin. One day after immunization, mice were treated with 0,1 mu g of 1 alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) every other day during 15 days (on days 1, 3, 5, 7, 9, 11, 13 and 15). MOG (150 mu g) was coadministered on days 3 and 11. The administration of 1,25(OH)(2)D-3 or MOG determined significant reduction in EAE incidence and in clinical scores. When MOG was associated with 1,25(OH)(2)D-3 the animals did not develop EAE. Spleen and central nervous system (CNS) cell cultures from this group produced less IL-6 and IL-17 upon stimulation with MOG in comparison to the EAE control group. In addition, this treatment inhibited dendritic cells maturation in the spleen and reduced inflammatory infiltration in the CNS. The association of MOG with 1,25(OH)(2)D-3 was able to control EAE development.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista UNESP, Biosci Inst, Dept Microbiol &Immunol, Botucatu, SP, BrazilFundacao Dr Amaral Carvalho, Lab Citometria Fluxo, Jau, SP, BrazilUniv Estadual Paulista UNESP, Biosci Inst, Dept Microbiol &Immunol, Botucatu, SP, BrazilCNPq: 301770/2009-3FAPESP: 2011/00465-8Public Library ScienceUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Chiuso-Minicucci, Fernanda [UNESP]Watanabe Ishikawa, Larissa Lumi [UNESP]Nishiyama Mimura, Luiza Ayumi [UNESP]Campos Fraga-Silva, Thais Fernanda de [UNESP]Donega Franca, Thais Graziela [UNESP]Fernanda Goncalves Zorzella-Pezavento, Sofia [UNESP]Marques, CamilaValerio Ikoma, Maura RosaneSartori, Alexandrina [UNESP]2015-10-21T13:11:23Z2015-10-21T13:11:23Z2015-05-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-14application/pdfhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125836Plos One. San Francisco: Public Library Science, v. 10, n. 5, p. 1-14, 2015.1932-6203http://hdl.handle.net/11449/12860110.1371/journal.pone.0125836WOS:000354543500030WOS000354543500030.pdf4977572416129527Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlos One2.7661,164info:eu-repo/semantics/openAccess2023-11-21T06:16:38Zoai:repositorio.unesp.br:11449/128601Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-21T06:16:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis |
title |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis |
spellingShingle |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis Chiuso-Minicucci, Fernanda [UNESP] |
title_short |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis |
title_full |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis |
title_fullStr |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis |
title_full_unstemmed |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis |
title_sort |
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis |
author |
Chiuso-Minicucci, Fernanda [UNESP] |
author_facet |
Chiuso-Minicucci, Fernanda [UNESP] Watanabe Ishikawa, Larissa Lumi [UNESP] Nishiyama Mimura, Luiza Ayumi [UNESP] Campos Fraga-Silva, Thais Fernanda de [UNESP] Donega Franca, Thais Graziela [UNESP] Fernanda Goncalves Zorzella-Pezavento, Sofia [UNESP] Marques, Camila Valerio Ikoma, Maura Rosane Sartori, Alexandrina [UNESP] |
author_role |
author |
author2 |
Watanabe Ishikawa, Larissa Lumi [UNESP] Nishiyama Mimura, Luiza Ayumi [UNESP] Campos Fraga-Silva, Thais Fernanda de [UNESP] Donega Franca, Thais Graziela [UNESP] Fernanda Goncalves Zorzella-Pezavento, Sofia [UNESP] Marques, Camila Valerio Ikoma, Maura Rosane Sartori, Alexandrina [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Chiuso-Minicucci, Fernanda [UNESP] Watanabe Ishikawa, Larissa Lumi [UNESP] Nishiyama Mimura, Luiza Ayumi [UNESP] Campos Fraga-Silva, Thais Fernanda de [UNESP] Donega Franca, Thais Graziela [UNESP] Fernanda Goncalves Zorzella-Pezavento, Sofia [UNESP] Marques, Camila Valerio Ikoma, Maura Rosane Sartori, Alexandrina [UNESP] |
description |
Experimental autoimmune encephalomyelitis (EAE) is an animal model to study multiple sclerosis (MS). Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte glycoprotein (MOG) associated with active vitamin D in EAE development. EAE was induced in female C57BL/6 mice by immunization with MOG emulsified with Complete Freund's Adjuvant plus Mycobacterium tuberculosis. Animals also received two intraperitoneal doses of Bordetella pertussis toxin. One day after immunization, mice were treated with 0,1 mu g of 1 alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) every other day during 15 days (on days 1, 3, 5, 7, 9, 11, 13 and 15). MOG (150 mu g) was coadministered on days 3 and 11. The administration of 1,25(OH)(2)D-3 or MOG determined significant reduction in EAE incidence and in clinical scores. When MOG was associated with 1,25(OH)(2)D-3 the animals did not develop EAE. Spleen and central nervous system (CNS) cell cultures from this group produced less IL-6 and IL-17 upon stimulation with MOG in comparison to the EAE control group. In addition, this treatment inhibited dendritic cells maturation in the spleen and reduced inflammatory infiltration in the CNS. The association of MOG with 1,25(OH)(2)D-3 was able to control EAE development. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:11:23Z 2015-10-21T13:11:23Z 2015-05-12 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125836 Plos One. San Francisco: Public Library Science, v. 10, n. 5, p. 1-14, 2015. 1932-6203 http://hdl.handle.net/11449/128601 10.1371/journal.pone.0125836 WOS:000354543500030 WOS000354543500030.pdf 4977572416129527 |
url |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125836 http://hdl.handle.net/11449/128601 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 10, n. 5, p. 1-14, 2015. 1932-6203 10.1371/journal.pone.0125836 WOS:000354543500030 WOS000354543500030.pdf 4977572416129527 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plos One 2.766 1,164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-14 application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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