Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma

• Autor(a) principal: Borba, M.
• Data de Publicação: 2010
• Outros Autores: Cernea, C., Dias, F., Faria, P., Bacchi, C., Brandão, L., Costa, A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1159/000319904; http://hdl.handle.net/11449/219584
• topic: Laryngeal cancer; Laryngeal squamous cell carcinoma; p63 expression

Objectives: To evaluate p63 expression in laryngeal squamous cell carcinoma and its prognostic significance. Methods: p63 expression was examined by immunohistochemistry and scored in 127 patients with laryngeal squamous cell carcinomas. Results: Sixty-two cases had scored 3, sixty had scored 2, four had scored 1 and one case did not show any expression (48.8, 47.2, 3.1 and 0.8%, respectively). Overall survival was 73.9% at 24 months and 59.5% at 60 months. The disease-free survival was 77.2 and 75.1%, and the disease-specific survival was 79 and 67% at 24 and 60 months, respectively. Uni- and multivariate analysis identified that decreased immunoexpression of protein p63 was a statistically significant factor for the risk of recurrence and death by cancer. Conclusions: p63 expression was highly prevalent in laryngeal squamous cell carcinomas, and its underexpression was correlated with a worse prognosis. Copyright © 2010 S. Karger AG, Basel.