Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Borba, M.
Data de Publicação: 2010
Outros Autores: Cernea, C., Dias, F., Faria, P., Bacchi, C., Brandão, L., Costa, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1159/000319904
http://hdl.handle.net/11449/219584
Resumo: Objectives: To evaluate p63 expression in laryngeal squamous cell carcinoma and its prognostic significance. Methods: p63 expression was examined by immunohistochemistry and scored in 127 patients with laryngeal squamous cell carcinomas. Results: Sixty-two cases had scored 3, sixty had scored 2, four had scored 1 and one case did not show any expression (48.8, 47.2, 3.1 and 0.8%, respectively). Overall survival was 73.9% at 24 months and 59.5% at 60 months. The disease-free survival was 77.2 and 75.1%, and the disease-specific survival was 79 and 67% at 24 and 60 months, respectively. Uni- and multivariate analysis identified that decreased immunoexpression of protein p63 was a statistically significant factor for the risk of recurrence and death by cancer. Conclusions: p63 expression was highly prevalent in laryngeal squamous cell carcinomas, and its underexpression was correlated with a worse prognosis. Copyright © 2010 S. Karger AG, Basel.
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spelling Expression profile of p63 in 127 patients with laryngeal squamous cell carcinomaLaryngeal cancerLaryngeal squamous cell carcinomap63 expressionObjectives: To evaluate p63 expression in laryngeal squamous cell carcinoma and its prognostic significance. Methods: p63 expression was examined by immunohistochemistry and scored in 127 patients with laryngeal squamous cell carcinomas. Results: Sixty-two cases had scored 3, sixty had scored 2, four had scored 1 and one case did not show any expression (48.8, 47.2, 3.1 and 0.8%, respectively). Overall survival was 73.9% at 24 months and 59.5% at 60 months. The disease-free survival was 77.2 and 75.1%, and the disease-specific survival was 79 and 67% at 24 and 60 months, respectively. Uni- and multivariate analysis identified that decreased immunoexpression of protein p63 was a statistically significant factor for the risk of recurrence and death by cancer. Conclusions: p63 expression was highly prevalent in laryngeal squamous cell carcinomas, and its underexpression was correlated with a worse prognosis. Copyright © 2010 S. Karger AG, Basel.Aristides Maltez Hospital, R. Colmar Americano da Costa 519/202, Salvador da Bahia 41830-600University of São Paulo, São PauloUniversity of the State of São Paulo, São PauloNational Cancer Institute, Rio de JaneiroAristides Maltez HospitalUniversidade de São Paulo (USP)University of the State of São PauloNational Cancer InstituteBorba, M.Cernea, C.Dias, F.Faria, P.Bacchi, C.Brandão, L.Costa, A.2022-04-28T18:56:19Z2022-04-28T18:56:19Z2010-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article319-324http://dx.doi.org/10.1159/000319904ORL, v. 72, n. 6, p. 319-324, 2010.0301-1569http://hdl.handle.net/11449/21958410.1159/0003199042-s2.0-77956604710Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengORLinfo:eu-repo/semantics/openAccess2022-04-28T18:56:19Zoai:repositorio.unesp.br:11449/219584Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:38:40.888433Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
title Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
spellingShingle Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
Borba, M.
Laryngeal cancer
Laryngeal squamous cell carcinoma
p63 expression
title_short Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
title_full Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
title_fullStr Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
title_full_unstemmed Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
title_sort Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma
author Borba, M.
author_facet Borba, M.
Cernea, C.
Dias, F.
Faria, P.
Bacchi, C.
Brandão, L.
Costa, A.
author_role author
author2 Cernea, C.
Dias, F.
Faria, P.
Bacchi, C.
Brandão, L.
Costa, A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Aristides Maltez Hospital
Universidade de São Paulo (USP)
University of the State of São Paulo
National Cancer Institute
dc.contributor.author.fl_str_mv Borba, M.
Cernea, C.
Dias, F.
Faria, P.
Bacchi, C.
Brandão, L.
Costa, A.
dc.subject.por.fl_str_mv Laryngeal cancer
Laryngeal squamous cell carcinoma
p63 expression
topic Laryngeal cancer
Laryngeal squamous cell carcinoma
p63 expression
description Objectives: To evaluate p63 expression in laryngeal squamous cell carcinoma and its prognostic significance. Methods: p63 expression was examined by immunohistochemistry and scored in 127 patients with laryngeal squamous cell carcinomas. Results: Sixty-two cases had scored 3, sixty had scored 2, four had scored 1 and one case did not show any expression (48.8, 47.2, 3.1 and 0.8%, respectively). Overall survival was 73.9% at 24 months and 59.5% at 60 months. The disease-free survival was 77.2 and 75.1%, and the disease-specific survival was 79 and 67% at 24 and 60 months, respectively. Uni- and multivariate analysis identified that decreased immunoexpression of protein p63 was a statistically significant factor for the risk of recurrence and death by cancer. Conclusions: p63 expression was highly prevalent in laryngeal squamous cell carcinomas, and its underexpression was correlated with a worse prognosis. Copyright © 2010 S. Karger AG, Basel.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
2022-04-28T18:56:19Z
2022-04-28T18:56:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1159/000319904
ORL, v. 72, n. 6, p. 319-324, 2010.
0301-1569
http://hdl.handle.net/11449/219584
10.1159/000319904
2-s2.0-77956604710
url http://dx.doi.org/10.1159/000319904
http://hdl.handle.net/11449/219584
identifier_str_mv ORL, v. 72, n. 6, p. 319-324, 2010.
0301-1569
10.1159/000319904
2-s2.0-77956604710
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv ORL
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 319-324
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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