Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/pharmaceutics13030407 http://hdl.handle.net/11449/208528 |
Resumo: | Polymer blends of gellan gum (GG)/retrograded starch(RS) and GG/pectin (P) were cross-linked with calcium, aluminum, or both to prepare mucoadhesive microparticles as oral carriers of drugs or nano systems. Cross-linking with different cations promoted different effects on each blend, which can potentially be explored as novel strategies for modulating physical-chemical and mucoadhesive properties of microparticles. Particles exhibited spherical shapes, diameters from 888 to 1764 µm, and span index values lower than 0.5. Blends of GG: P cross-linked with aluminum resulted in smaller particles than those obtained by calcium cross-linking. GG: RS particles exhibited larger sizes, but cross-linking this blend with calcium promoted diameter reduction. The uptake rates of acid medium were lower than phosphate buffer (pH 6.8), especially GG: RS based particles cross-linked with calcium. On the other hand, particles based on GG: P cross-linked with calcium absorbed the highest volume of acid medium. The percentage of systems erosion was higher in acid medium, but apparently occurred in the outermost layer of the particle. In pH 6.8, erosion was lower, but caused expressive swelling of the matrixes. Calcium cross-linking of GG: RS promoted a significantly reduction on enzymatic degradation at both pH 1.2 and 6.8, which is a promising feature that can provide drug protection against premature degradation in the stomach. In contrast, GG: P microparticles cross-linked with calcium suffered high degradation at both pH values, an advantageous feature for quickly releasing drugs at different sites of the gastrointestinal tract. The high mucoadhesive ability of the microparticles was evidenced at both pH values, and the Freundlich parameters indicated stronger particle-mucin interactions at pH 6.8. |
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spelling |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blendsEnzymatic degradationErosionGellan gumLiquid uptakeMucoadhesionPectinRetrograded starchPolymer blends of gellan gum (GG)/retrograded starch(RS) and GG/pectin (P) were cross-linked with calcium, aluminum, or both to prepare mucoadhesive microparticles as oral carriers of drugs or nano systems. Cross-linking with different cations promoted different effects on each blend, which can potentially be explored as novel strategies for modulating physical-chemical and mucoadhesive properties of microparticles. Particles exhibited spherical shapes, diameters from 888 to 1764 µm, and span index values lower than 0.5. Blends of GG: P cross-linked with aluminum resulted in smaller particles than those obtained by calcium cross-linking. GG: RS particles exhibited larger sizes, but cross-linking this blend with calcium promoted diameter reduction. The uptake rates of acid medium were lower than phosphate buffer (pH 6.8), especially GG: RS based particles cross-linked with calcium. On the other hand, particles based on GG: P cross-linked with calcium absorbed the highest volume of acid medium. The percentage of systems erosion was higher in acid medium, but apparently occurred in the outermost layer of the particle. In pH 6.8, erosion was lower, but caused expressive swelling of the matrixes. Calcium cross-linking of GG: RS promoted a significantly reduction on enzymatic degradation at both pH 1.2 and 6.8, which is a promising feature that can provide drug protection against premature degradation in the stomach. In contrast, GG: P microparticles cross-linked with calcium suffered high degradation at both pH values, an advantageous feature for quickly releasing drugs at different sites of the gastrointestinal tract. The high mucoadhesive ability of the microparticles was evidenced at both pH values, and the Freundlich parameters indicated stronger particle-mucin interactions at pH 6.8.School of Pharmaceutical Science São Paulo State University (UNESP) Araraquara, Road Araraquara-Jaú, Km 01School of Pharmaceutical Science São Paulo State University (UNESP) Araraquara, Road Araraquara-Jaú, Km 01Universidade Estadual Paulista (Unesp)Boni, Fernanda Isadora [UNESP]Cury, Beatriz S. F. [UNESP]Ferreira, Natália Noronha [UNESP]Gremião, Maria Palmira Daflon [UNESP]2021-06-25T11:13:36Z2021-06-25T11:13:36Z2021-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/pharmaceutics13030407Pharmaceutics, v. 13, n. 3, 2021.1999-4923http://hdl.handle.net/11449/20852810.3390/pharmaceutics130304072-s2.0-85103134722Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticsinfo:eu-repo/semantics/openAccess2021-10-23T19:02:14Zoai:repositorio.unesp.br:11449/208528Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:02:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends |
title |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends |
spellingShingle |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends Boni, Fernanda Isadora [UNESP] Enzymatic degradation Erosion Gellan gum Liquid uptake Mucoadhesion Pectin Retrograded starch |
title_short |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends |
title_full |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends |
title_fullStr |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends |
title_full_unstemmed |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends |
title_sort |
Ionic cross-linking as a strategy tomodulate the properties of oral mucoadhesive microparticles based on polysaccharide blends |
author |
Boni, Fernanda Isadora [UNESP] |
author_facet |
Boni, Fernanda Isadora [UNESP] Cury, Beatriz S. F. [UNESP] Ferreira, Natália Noronha [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author_role |
author |
author2 |
Cury, Beatriz S. F. [UNESP] Ferreira, Natália Noronha [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Boni, Fernanda Isadora [UNESP] Cury, Beatriz S. F. [UNESP] Ferreira, Natália Noronha [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
dc.subject.por.fl_str_mv |
Enzymatic degradation Erosion Gellan gum Liquid uptake Mucoadhesion Pectin Retrograded starch |
topic |
Enzymatic degradation Erosion Gellan gum Liquid uptake Mucoadhesion Pectin Retrograded starch |
description |
Polymer blends of gellan gum (GG)/retrograded starch(RS) and GG/pectin (P) were cross-linked with calcium, aluminum, or both to prepare mucoadhesive microparticles as oral carriers of drugs or nano systems. Cross-linking with different cations promoted different effects on each blend, which can potentially be explored as novel strategies for modulating physical-chemical and mucoadhesive properties of microparticles. Particles exhibited spherical shapes, diameters from 888 to 1764 µm, and span index values lower than 0.5. Blends of GG: P cross-linked with aluminum resulted in smaller particles than those obtained by calcium cross-linking. GG: RS particles exhibited larger sizes, but cross-linking this blend with calcium promoted diameter reduction. The uptake rates of acid medium were lower than phosphate buffer (pH 6.8), especially GG: RS based particles cross-linked with calcium. On the other hand, particles based on GG: P cross-linked with calcium absorbed the highest volume of acid medium. The percentage of systems erosion was higher in acid medium, but apparently occurred in the outermost layer of the particle. In pH 6.8, erosion was lower, but caused expressive swelling of the matrixes. Calcium cross-linking of GG: RS promoted a significantly reduction on enzymatic degradation at both pH 1.2 and 6.8, which is a promising feature that can provide drug protection against premature degradation in the stomach. In contrast, GG: P microparticles cross-linked with calcium suffered high degradation at both pH values, an advantageous feature for quickly releasing drugs at different sites of the gastrointestinal tract. The high mucoadhesive ability of the microparticles was evidenced at both pH values, and the Freundlich parameters indicated stronger particle-mucin interactions at pH 6.8. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:13:36Z 2021-06-25T11:13:36Z 2021-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/pharmaceutics13030407 Pharmaceutics, v. 13, n. 3, 2021. 1999-4923 http://hdl.handle.net/11449/208528 10.3390/pharmaceutics13030407 2-s2.0-85103134722 |
url |
http://dx.doi.org/10.3390/pharmaceutics13030407 http://hdl.handle.net/11449/208528 |
identifier_str_mv |
Pharmaceutics, v. 13, n. 3, 2021. 1999-4923 10.3390/pharmaceutics13030407 2-s2.0-85103134722 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceutics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965215912099840 |