Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome

Detalhes bibliográficos
Autor(a) principal: Onofre, Mirian Aparecida [UNESP]
Data de Publicação: 2003
Outros Autores: Brosco, Heli Benedito, Taga, Rumio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-77572003000300008
http://hdl.handle.net/11449/213047
Resumo: The objective of the present study was to evaluate the glands of wall of congenital fistulae of the lower lip with the transmission electron microscope in order to characterize their microstructural pattern. Thin section of Araldite resin embedded congenital fistulae of the lower lip of four patients with Van der Woude syndrome from the Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo, Bauru, SP, were analyzed with a transmission electron microscope. The results showed that the glands were mostly made by typical mucous acini exhibiting, with certain frequency, myoepithelial cells surrounding them. In some of lobules, a few acini smaller than the typical mucous, showed granules of moderate electron density or containing a dense core or exhibiting small dense spherule and predominance granular material. These granules resemble to described recently by others in various human minor salivary glands. We concluded that glands associated with congenital fistula of lower lip of patients with Van der Woude syndrome, in spite of being located in vermilion border of the lip, showed at the transmission electron microscope characteristics of labial minor salivary gland, i.e, are mostly mucous with a few seromucous units, while typical seromucous demilunes are not present.
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spelling Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndromeAnálise ultra-estrutural das glândulas localizadas na parede da fístula congênita de lábio inferior de pacientes com a síndrome de Van der WoudeFistulaLip diseasesVan der Woude syndromeFístulaDoença labialSindrome de Van der WoudeThe objective of the present study was to evaluate the glands of wall of congenital fistulae of the lower lip with the transmission electron microscope in order to characterize their microstructural pattern. Thin section of Araldite resin embedded congenital fistulae of the lower lip of four patients with Van der Woude syndrome from the Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo, Bauru, SP, were analyzed with a transmission electron microscope. The results showed that the glands were mostly made by typical mucous acini exhibiting, with certain frequency, myoepithelial cells surrounding them. In some of lobules, a few acini smaller than the typical mucous, showed granules of moderate electron density or containing a dense core or exhibiting small dense spherule and predominance granular material. These granules resemble to described recently by others in various human minor salivary glands. We concluded that glands associated with congenital fistula of lower lip of patients with Van der Woude syndrome, in spite of being located in vermilion border of the lip, showed at the transmission electron microscope characteristics of labial minor salivary gland, i.e, are mostly mucous with a few seromucous units, while typical seromucous demilunes are not present.O objetivo do presente estudo foi avaliar a ultraestrutura de glândulas da parede de fístula congênita de lábio inferior ao microscópio eletrônico de transmissão para caracterizar seu padrão microestrutural. Deste modo, as fístulas congênitas de 4 pacientes com a síndrome de Van der Woude do Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de Sâo Paulo, Bauru, SP, foram processadas para inclusão em resina Araldite e os cortes finos foram analisados no microscópio eletrônico de transmissão. Os resultados mostraram que as glândulas estavam constituídas por ácinos mucosos típicos exibindo com certa freqüência células mioepiteliais ao seu redor. Em alguns lóbulos, foram observados em pequeno número, ácinos menores que o mucoso típico, exibindo células com grânulos de moderada eletron-densidade contendo um corpo denso ou uma pequena esférula densa no interior de um material predominante granular. Estes grânulos lembravam os descritos recentemente em glândulas salivares labiais humanas. Em vista dos resultados obtidos concluímos que as glândulas associadas com a fístula congênita de lábio inferior de pacientes com a síndrome de Van der Woude, apesar de estarem localizadas no vermelhão do lábio, mostraram ao microscópio eletrônico de transmissão características de glândula salivar labial, i.e., são predominantemente mucosos com poucas unidades seromucosas, mas semiluas seromucosas típicas não estão presentes.Universidade de São Paulo, Laboratory of Histology-Dentistry School of BauruUniversidade Estadual Paulista, Dental School of AraraquaraUniversidade de São Paulo, Cleft Lip-Palate Research and Rehabilitation HospitalUniversidade Estadual Paulista, Dental School of AraraquaraFaculdade De Odontologia De Bauru - USPUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Onofre, Mirian Aparecida [UNESP]Brosco, Heli BeneditoTaga, Rumio2021-07-14T10:49:09Z2021-07-14T10:49:09Z2003-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article192-202application/pdfhttp://dx.doi.org/10.1590/S1678-77572003000300008Journal of Applied Oral Science. Bauru, SP, Brazil: Faculdade De Odontologia De Bauru - USP, v. 11, n. 3, p. 192-202, 2003.1678-77571678-7765http://hdl.handle.net/11449/21304710.1590/S1678-77572003000300008S1678-77572003000300008S1678-77572003000300008.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccess2023-11-05T06:10:04Zoai:repositorio.unesp.br:11449/213047Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:58:57.234701Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
Análise ultra-estrutural das glândulas localizadas na parede da fístula congênita de lábio inferior de pacientes com a síndrome de Van der Woude
title Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
spellingShingle Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
Onofre, Mirian Aparecida [UNESP]
Fistula
Lip diseases
Van der Woude syndrome
Fístula
Doença labial
Sindrome de Van der Woude
title_short Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
title_full Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
title_fullStr Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
title_full_unstemmed Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
title_sort Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome
author Onofre, Mirian Aparecida [UNESP]
author_facet Onofre, Mirian Aparecida [UNESP]
Brosco, Heli Benedito
Taga, Rumio
author_role author
author2 Brosco, Heli Benedito
Taga, Rumio
author2_role author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Onofre, Mirian Aparecida [UNESP]
Brosco, Heli Benedito
Taga, Rumio
dc.subject.por.fl_str_mv Fistula
Lip diseases
Van der Woude syndrome
Fístula
Doença labial
Sindrome de Van der Woude
topic Fistula
Lip diseases
Van der Woude syndrome
Fístula
Doença labial
Sindrome de Van der Woude
description The objective of the present study was to evaluate the glands of wall of congenital fistulae of the lower lip with the transmission electron microscope in order to characterize their microstructural pattern. Thin section of Araldite resin embedded congenital fistulae of the lower lip of four patients with Van der Woude syndrome from the Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo, Bauru, SP, were analyzed with a transmission electron microscope. The results showed that the glands were mostly made by typical mucous acini exhibiting, with certain frequency, myoepithelial cells surrounding them. In some of lobules, a few acini smaller than the typical mucous, showed granules of moderate electron density or containing a dense core or exhibiting small dense spherule and predominance granular material. These granules resemble to described recently by others in various human minor salivary glands. We concluded that glands associated with congenital fistula of lower lip of patients with Van der Woude syndrome, in spite of being located in vermilion border of the lip, showed at the transmission electron microscope characteristics of labial minor salivary gland, i.e, are mostly mucous with a few seromucous units, while typical seromucous demilunes are not present.
publishDate 2003
dc.date.none.fl_str_mv 2003-09
2021-07-14T10:49:09Z
2021-07-14T10:49:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-77572003000300008
Journal of Applied Oral Science. Bauru, SP, Brazil: Faculdade De Odontologia De Bauru - USP, v. 11, n. 3, p. 192-202, 2003.
1678-7757
1678-7765
http://hdl.handle.net/11449/213047
10.1590/S1678-77572003000300008
S1678-77572003000300008
S1678-77572003000300008.pdf
url http://dx.doi.org/10.1590/S1678-77572003000300008
http://hdl.handle.net/11449/213047
identifier_str_mv Journal of Applied Oral Science. Bauru, SP, Brazil: Faculdade De Odontologia De Bauru - USP, v. 11, n. 3, p. 192-202, 2003.
1678-7757
1678-7765
10.1590/S1678-77572003000300008
S1678-77572003000300008
S1678-77572003000300008.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Applied Oral Science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 192-202
application/pdf
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128729367445504

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