Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/abd1806-4841.20164628 http://hdl.handle.net/11449/178588 |
Resumo: | Granuloma faciale is a chronic, benign, cutaneous vasculitis with well-established clinical and morphological patterns, but with an unknown etiology. This study describes clinical and pathologic aspects of patients diagnosed with granuloma faciale. The authors analyzed demographic, clinical, morphological and immunohistochemical data from patients with a final diagnosis of granuloma faciale, confirmed between 1998 and 2012. There was a proportional and mixed inflammatory infiltrate, Grenz zones were present in almost all the samples. Immunophenotyping confirmed a higher intensity of T lymphocytes than B lymphocytes in thirteen samples, with a predominance of T CD8 lymphocytes in 64% of cases, in contrast to the literature, which indicates that the major component is T CD4 lymphocytes. All cases were positive for IgG4 but the majority (12/14) had less than 25% of stained cells. The pathogenesis of granuloma faciale remains poorly understood, making studies of morphological and immunohistochemical characterization important to better understand it. |
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Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patientsImmunohistochemistryInflammationPathologySkinVasculitisGranuloma faciale is a chronic, benign, cutaneous vasculitis with well-established clinical and morphological patterns, but with an unknown etiology. This study describes clinical and pathologic aspects of patients diagnosed with granuloma faciale. The authors analyzed demographic, clinical, morphological and immunohistochemical data from patients with a final diagnosis of granuloma faciale, confirmed between 1998 and 2012. There was a proportional and mixed inflammatory infiltrate, Grenz zones were present in almost all the samples. Immunophenotyping confirmed a higher intensity of T lymphocytes than B lymphocytes in thirteen samples, with a predominance of T CD8 lymphocytes in 64% of cases, in contrast to the literature, which indicates that the major component is T CD4 lymphocytes. All cases were positive for IgG4 but the majority (12/14) had less than 25% of stained cells. The pathogenesis of granuloma faciale remains poorly understood, making studies of morphological and immunohistochemical characterization important to better understand it.Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Hospital IpirangaUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Universidade Estadual Paulista (Unesp)Hospital IpirangaOliveira, Cristiano Claudino [UNESP]Ianhez, Pedro Eugênio de CarvalhoMarques, Silvio Alencar [UNESP]Marques, Mariângela Esther Alencar [UNESP]2018-12-11T17:31:12Z2018-12-11T17:31:12Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article803-807application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20164628Anais Brasileiros de Dermatologia, v. 91, n. 6, p. 803-807, 2016.1806-48410365-0596http://hdl.handle.net/11449/17858810.1590/abd1806-4841.20164628S0365-059620160006008032-s2.0-85009812372S0365-05962016000600803.pdf7528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2024-09-03T13:15:04Zoai:repositorio.unesp.br:11449/178588Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients |
title |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients |
spellingShingle |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients Oliveira, Cristiano Claudino [UNESP] Immunohistochemistry Inflammation Pathology Skin Vasculitis |
title_short |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients |
title_full |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients |
title_fullStr |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients |
title_full_unstemmed |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients |
title_sort |
Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients |
author |
Oliveira, Cristiano Claudino [UNESP] |
author_facet |
Oliveira, Cristiano Claudino [UNESP] Ianhez, Pedro Eugênio de Carvalho Marques, Silvio Alencar [UNESP] Marques, Mariângela Esther Alencar [UNESP] |
author_role |
author |
author2 |
Ianhez, Pedro Eugênio de Carvalho Marques, Silvio Alencar [UNESP] Marques, Mariângela Esther Alencar [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Hospital Ipiranga |
dc.contributor.author.fl_str_mv |
Oliveira, Cristiano Claudino [UNESP] Ianhez, Pedro Eugênio de Carvalho Marques, Silvio Alencar [UNESP] Marques, Mariângela Esther Alencar [UNESP] |
dc.subject.por.fl_str_mv |
Immunohistochemistry Inflammation Pathology Skin Vasculitis |
topic |
Immunohistochemistry Inflammation Pathology Skin Vasculitis |
description |
Granuloma faciale is a chronic, benign, cutaneous vasculitis with well-established clinical and morphological patterns, but with an unknown etiology. This study describes clinical and pathologic aspects of patients diagnosed with granuloma faciale. The authors analyzed demographic, clinical, morphological and immunohistochemical data from patients with a final diagnosis of granuloma faciale, confirmed between 1998 and 2012. There was a proportional and mixed inflammatory infiltrate, Grenz zones were present in almost all the samples. Immunophenotyping confirmed a higher intensity of T lymphocytes than B lymphocytes in thirteen samples, with a predominance of T CD8 lymphocytes in 64% of cases, in contrast to the literature, which indicates that the major component is T CD4 lymphocytes. All cases were positive for IgG4 but the majority (12/14) had less than 25% of stained cells. The pathogenesis of granuloma faciale remains poorly understood, making studies of morphological and immunohistochemical characterization important to better understand it. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 2018-12-11T17:31:12Z 2018-12-11T17:31:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/abd1806-4841.20164628 Anais Brasileiros de Dermatologia, v. 91, n. 6, p. 803-807, 2016. 1806-4841 0365-0596 http://hdl.handle.net/11449/178588 10.1590/abd1806-4841.20164628 S0365-05962016000600803 2-s2.0-85009812372 S0365-05962016000600803.pdf 7528116925519142 |
url |
http://dx.doi.org/10.1590/abd1806-4841.20164628 http://hdl.handle.net/11449/178588 |
identifier_str_mv |
Anais Brasileiros de Dermatologia, v. 91, n. 6, p. 803-807, 2016. 1806-4841 0365-0596 10.1590/abd1806-4841.20164628 S0365-05962016000600803 2-s2.0-85009812372 S0365-05962016000600803.pdf 7528116925519142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais Brasileiros de Dermatologia 0,520 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
803-807 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021380586995712 |