Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients

Detalhes bibliográficos
Autor(a) principal: Oliveira, Cristiano Claudino [UNESP]
Data de Publicação: 2016
Outros Autores: Ianhez, Pedro Eugênio de Carvalho, Marques, Silvio Alencar [UNESP], Marques, Mariângela Esther Alencar [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20164628
http://hdl.handle.net/11449/178588
Resumo: Granuloma faciale is a chronic, benign, cutaneous vasculitis with well-established clinical and morphological patterns, but with an unknown etiology. This study describes clinical and pathologic aspects of patients diagnosed with granuloma faciale. The authors analyzed demographic, clinical, morphological and immunohistochemical data from patients with a final diagnosis of granuloma faciale, confirmed between 1998 and 2012. There was a proportional and mixed inflammatory infiltrate, Grenz zones were present in almost all the samples. Immunophenotyping confirmed a higher intensity of T lymphocytes than B lymphocytes in thirteen samples, with a predominance of T CD8 lymphocytes in 64% of cases, in contrast to the literature, which indicates that the major component is T CD4 lymphocytes. All cases were positive for IgG4 but the majority (12/14) had less than 25% of stained cells. The pathogenesis of granuloma faciale remains poorly understood, making studies of morphological and immunohistochemical characterization important to better understand it.
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spelling Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patientsImmunohistochemistryInflammationPathologySkinVasculitisGranuloma faciale is a chronic, benign, cutaneous vasculitis with well-established clinical and morphological patterns, but with an unknown etiology. This study describes clinical and pathologic aspects of patients diagnosed with granuloma faciale. The authors analyzed demographic, clinical, morphological and immunohistochemical data from patients with a final diagnosis of granuloma faciale, confirmed between 1998 and 2012. There was a proportional and mixed inflammatory infiltrate, Grenz zones were present in almost all the samples. Immunophenotyping confirmed a higher intensity of T lymphocytes than B lymphocytes in thirteen samples, with a predominance of T CD8 lymphocytes in 64% of cases, in contrast to the literature, which indicates that the major component is T CD4 lymphocytes. All cases were positive for IgG4 but the majority (12/14) had less than 25% of stained cells. The pathogenesis of granuloma faciale remains poorly understood, making studies of morphological and immunohistochemical characterization important to better understand it.Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Hospital IpirangaUniversidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Universidade Estadual Paulista (Unesp)Hospital IpirangaOliveira, Cristiano Claudino [UNESP]Ianhez, Pedro Eugênio de CarvalhoMarques, Silvio Alencar [UNESP]Marques, Mariângela Esther Alencar [UNESP]2018-12-11T17:31:12Z2018-12-11T17:31:12Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article803-807application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20164628Anais Brasileiros de Dermatologia, v. 91, n. 6, p. 803-807, 2016.1806-48410365-0596http://hdl.handle.net/11449/17858810.1590/abd1806-4841.20164628S0365-059620160006008032-s2.0-85009812372S0365-05962016000600803.pdf7528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2024-09-03T13:15:04Zoai:repositorio.unesp.br:11449/178588Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
title Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
spellingShingle Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
Oliveira, Cristiano Claudino [UNESP]
Immunohistochemistry
Inflammation
Pathology
Skin
Vasculitis
title_short Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
title_full Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
title_fullStr Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
title_full_unstemmed Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
title_sort Granuloma faciale: Clinical, morphological and immunohistochemical aspects in a series of 10 patients
author Oliveira, Cristiano Claudino [UNESP]
author_facet Oliveira, Cristiano Claudino [UNESP]
Ianhez, Pedro Eugênio de Carvalho
Marques, Silvio Alencar [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
author_role author
author2 Ianhez, Pedro Eugênio de Carvalho
Marques, Silvio Alencar [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Hospital Ipiranga
dc.contributor.author.fl_str_mv Oliveira, Cristiano Claudino [UNESP]
Ianhez, Pedro Eugênio de Carvalho
Marques, Silvio Alencar [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
dc.subject.por.fl_str_mv Immunohistochemistry
Inflammation
Pathology
Skin
Vasculitis
topic Immunohistochemistry
Inflammation
Pathology
Skin
Vasculitis
description Granuloma faciale is a chronic, benign, cutaneous vasculitis with well-established clinical and morphological patterns, but with an unknown etiology. This study describes clinical and pathologic aspects of patients diagnosed with granuloma faciale. The authors analyzed demographic, clinical, morphological and immunohistochemical data from patients with a final diagnosis of granuloma faciale, confirmed between 1998 and 2012. There was a proportional and mixed inflammatory infiltrate, Grenz zones were present in almost all the samples. Immunophenotyping confirmed a higher intensity of T lymphocytes than B lymphocytes in thirteen samples, with a predominance of T CD8 lymphocytes in 64% of cases, in contrast to the literature, which indicates that the major component is T CD4 lymphocytes. All cases were positive for IgG4 but the majority (12/14) had less than 25% of stained cells. The pathogenesis of granuloma faciale remains poorly understood, making studies of morphological and immunohistochemical characterization important to better understand it.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-01
2018-12-11T17:31:12Z
2018-12-11T17:31:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20164628
Anais Brasileiros de Dermatologia, v. 91, n. 6, p. 803-807, 2016.
1806-4841
0365-0596
http://hdl.handle.net/11449/178588
10.1590/abd1806-4841.20164628
S0365-05962016000600803
2-s2.0-85009812372
S0365-05962016000600803.pdf
7528116925519142
url http://dx.doi.org/10.1590/abd1806-4841.20164628
http://hdl.handle.net/11449/178588
identifier_str_mv Anais Brasileiros de Dermatologia, v. 91, n. 6, p. 803-807, 2016.
1806-4841
0365-0596
10.1590/abd1806-4841.20164628
S0365-05962016000600803
2-s2.0-85009812372
S0365-05962016000600803.pdf
7528116925519142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
0,520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 803-807
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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