Lymphoepithelioma-like carcinoma of the skin

Detalhes bibliográficos
Autor(a) principal: Oliveira, Cristiano Claudino [UNESP]
Data de Publicação: 2018
Outros Autores: Marques, Mariângela Esther Alencar [UNESP], Nóbrega, Vinicius Cardoso [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20187205
http://hdl.handle.net/11449/176263
Resumo: Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.
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spelling Lymphoepithelioma-like carcinoma of the skinImmunohistochemistryPathologySkin neoplasmsPrimary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.Department of Pathology of the Botucatu School of Medicine Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-UNESP)Department of Pathology of the Botucatu School of Medicine Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-UNESP)Universidade Estadual Paulista (Unesp)Oliveira, Cristiano Claudino [UNESP]Marques, Mariângela Esther Alencar [UNESP]Nóbrega, Vinicius Cardoso [UNESP]2018-12-11T17:19:51Z2018-12-11T17:19:51Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article256-258application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20187205Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 256-258, 2018.1806-48410365-0596http://hdl.handle.net/11449/17626310.1590/abd1806-4841.20187205S0365-059620180002002562-s2.0-85046427410S0365-05962018000200256.pdf7528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2023-11-05T06:12:41Zoai:repositorio.unesp.br:11449/176263Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-05T06:12:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Lymphoepithelioma-like carcinoma of the skin
title Lymphoepithelioma-like carcinoma of the skin
spellingShingle Lymphoepithelioma-like carcinoma of the skin
Oliveira, Cristiano Claudino [UNESP]
Immunohistochemistry
Pathology
Skin neoplasms
title_short Lymphoepithelioma-like carcinoma of the skin
title_full Lymphoepithelioma-like carcinoma of the skin
title_fullStr Lymphoepithelioma-like carcinoma of the skin
title_full_unstemmed Lymphoepithelioma-like carcinoma of the skin
title_sort Lymphoepithelioma-like carcinoma of the skin
author Oliveira, Cristiano Claudino [UNESP]
author_facet Oliveira, Cristiano Claudino [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
Nóbrega, Vinicius Cardoso [UNESP]
author_role author
author2 Marques, Mariângela Esther Alencar [UNESP]
Nóbrega, Vinicius Cardoso [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Oliveira, Cristiano Claudino [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
Nóbrega, Vinicius Cardoso [UNESP]
dc.subject.por.fl_str_mv Immunohistochemistry
Pathology
Skin neoplasms
topic Immunohistochemistry
Pathology
Skin neoplasms
description Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:19:51Z
2018-12-11T17:19:51Z
2018-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20187205
Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 256-258, 2018.
1806-4841
0365-0596
http://hdl.handle.net/11449/176263
10.1590/abd1806-4841.20187205
S0365-05962018000200256
2-s2.0-85046427410
S0365-05962018000200256.pdf
7528116925519142
url http://dx.doi.org/10.1590/abd1806-4841.20187205
http://hdl.handle.net/11449/176263
identifier_str_mv Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 256-258, 2018.
1806-4841
0365-0596
10.1590/abd1806-4841.20187205
S0365-05962018000200256
2-s2.0-85046427410
S0365-05962018000200256.pdf
7528116925519142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
0,520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 256-258
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964831222071296

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