Lymphoepithelioma-like carcinoma of the skin
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/abd1806-4841.20187205 http://hdl.handle.net/11449/176263 |
Resumo: | Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates. |
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Lymphoepithelioma-like carcinoma of the skinImmunohistochemistryPathologySkin neoplasmsPrimary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.Department of Pathology of the Botucatu School of Medicine Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-UNESP)Department of Pathology of the Botucatu School of Medicine Universidade Estadual Paulista “Júlio de Mesquita Filho” (FMB-UNESP)Universidade Estadual Paulista (Unesp)Oliveira, Cristiano Claudino [UNESP]Marques, Mariângela Esther Alencar [UNESP]Nóbrega, Vinicius Cardoso [UNESP]2018-12-11T17:19:51Z2018-12-11T17:19:51Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article256-258application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20187205Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 256-258, 2018.1806-48410365-0596http://hdl.handle.net/11449/17626310.1590/abd1806-4841.20187205S0365-059620180002002562-s2.0-85046427410S0365-05962018000200256.pdf7528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2024-09-03T13:14:54Zoai:repositorio.unesp.br:11449/176263Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lymphoepithelioma-like carcinoma of the skin |
title |
Lymphoepithelioma-like carcinoma of the skin |
spellingShingle |
Lymphoepithelioma-like carcinoma of the skin Oliveira, Cristiano Claudino [UNESP] Immunohistochemistry Pathology Skin neoplasms |
title_short |
Lymphoepithelioma-like carcinoma of the skin |
title_full |
Lymphoepithelioma-like carcinoma of the skin |
title_fullStr |
Lymphoepithelioma-like carcinoma of the skin |
title_full_unstemmed |
Lymphoepithelioma-like carcinoma of the skin |
title_sort |
Lymphoepithelioma-like carcinoma of the skin |
author |
Oliveira, Cristiano Claudino [UNESP] |
author_facet |
Oliveira, Cristiano Claudino [UNESP] Marques, Mariângela Esther Alencar [UNESP] Nóbrega, Vinicius Cardoso [UNESP] |
author_role |
author |
author2 |
Marques, Mariângela Esther Alencar [UNESP] Nóbrega, Vinicius Cardoso [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Oliveira, Cristiano Claudino [UNESP] Marques, Mariângela Esther Alencar [UNESP] Nóbrega, Vinicius Cardoso [UNESP] |
dc.subject.por.fl_str_mv |
Immunohistochemistry Pathology Skin neoplasms |
topic |
Immunohistochemistry Pathology Skin neoplasms |
description |
Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:19:51Z 2018-12-11T17:19:51Z 2018-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/abd1806-4841.20187205 Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 256-258, 2018. 1806-4841 0365-0596 http://hdl.handle.net/11449/176263 10.1590/abd1806-4841.20187205 S0365-05962018000200256 2-s2.0-85046427410 S0365-05962018000200256.pdf 7528116925519142 |
url |
http://dx.doi.org/10.1590/abd1806-4841.20187205 http://hdl.handle.net/11449/176263 |
identifier_str_mv |
Anais Brasileiros de Dermatologia, v. 93, n. 2, p. 256-258, 2018. 1806-4841 0365-0596 10.1590/abd1806-4841.20187205 S0365-05962018000200256 2-s2.0-85046427410 S0365-05962018000200256.pdf 7528116925519142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais Brasileiros de Dermatologia 0,520 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
256-258 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021377238892544 |