Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/fsn3.2167 http://hdl.handle.net/11449/207287 |
Resumo: | Two compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8-heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high-fat diet (HFD) in C57BL/6J mice. In the first 4 weeks, mice were fed either a standard diet (11% kcal from fat) for the control group, or a HFD (45% kcal from fat) to establish obesity in three experimental groups. In the following 4 weeks, two groups receiving the HFD were supplemented with either TAN or HMF at daily doses of 100 mg/kg body weight, while the two remaining groups continued to receive the standard healthy diet or the nonsupplemented HFD. Four weeks of supplementation with TAN and HMF resulted in intermediate levels of blood serum glucose, leptin, resistin, and insulin resistance compared with the healthy control and the nonsupplemented HFD groups. Blood serum peroxidation (TBARS) levels were significantly lower in the TAN and HMF groups compared with the nonsupplemented HFD group. Several differences occurred in the physiological effects of HMF versus TAN. TAN, but not HMF, reduced adipocyte size in the mice with pre-existent obesity, while HMF, but not TAN, decreased fat accumulation in the liver and also significantly increased the levels of an anti-inflammatory cytokine, IL-10. In an analysis of the metabolites of TAN and HMF, several main classes occurred, including a new set of methylglucuronide conjugates. It is suggested that contrasts between the observed physiological effects of TAN and HMF may be attributable to the differences in numbers and chemical structures of TAN and HMF metabolites. |
id |
UNSP_2b00d98625960dc5b35a2e344744e679 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/207287 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavonescitrusflavonoidsinflammationmetabolitesobesityoxidative stressTwo compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8-heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high-fat diet (HFD) in C57BL/6J mice. In the first 4 weeks, mice were fed either a standard diet (11% kcal from fat) for the control group, or a HFD (45% kcal from fat) to establish obesity in three experimental groups. In the following 4 weeks, two groups receiving the HFD were supplemented with either TAN or HMF at daily doses of 100 mg/kg body weight, while the two remaining groups continued to receive the standard healthy diet or the nonsupplemented HFD. Four weeks of supplementation with TAN and HMF resulted in intermediate levels of blood serum glucose, leptin, resistin, and insulin resistance compared with the healthy control and the nonsupplemented HFD groups. Blood serum peroxidation (TBARS) levels were significantly lower in the TAN and HMF groups compared with the nonsupplemented HFD group. Several differences occurred in the physiological effects of HMF versus TAN. TAN, but not HMF, reduced adipocyte size in the mice with pre-existent obesity, while HMF, but not TAN, decreased fat accumulation in the liver and also significantly increased the levels of an anti-inflammatory cytokine, IL-10. In an analysis of the metabolites of TAN and HMF, several main classes occurred, including a new set of methylglucuronide conjugates. It is suggested that contrasts between the observed physiological effects of TAN and HMF may be attributable to the differences in numbers and chemical structures of TAN and HMF metabolites.Department of Food and Nutrition Laboratory of Nutrition Faculty of Pharmaceutical Sciences São Paulo State University (UNESP)U.S. Horticultural Research Laboratory Agricultural Research Service USDADepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)Department of Food and Nutrition Laboratory of Nutrition Faculty of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)USDANery, Marina [UNESP]Ferreira, Paula S. [UNESP]Gonçalves, Danielle R. [UNESP]Spolidorio, Luis C. [UNESP]Manthey, John A.Cesar, Thais B. [UNESP]2021-06-25T10:52:35Z2021-06-25T10:52:35Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1997-2009http://dx.doi.org/10.1002/fsn3.2167Food Science and Nutrition, v. 9, n. 4, p. 1997-2009, 2021.2048-7177http://hdl.handle.net/11449/20728710.1002/fsn3.21672-s2.0-85100839449Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood Science and Nutritioninfo:eu-repo/semantics/openAccess2024-06-21T12:46:39Zoai:repositorio.unesp.br:11449/207287Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:59:08.196781Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones |
title |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones |
spellingShingle |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones Nery, Marina [UNESP] citrus flavonoids inflammation metabolites obesity oxidative stress |
title_short |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones |
title_full |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones |
title_fullStr |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones |
title_full_unstemmed |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones |
title_sort |
Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high-fat diet and analyses of the metabolites originating from these two polymethoxylated flavones |
author |
Nery, Marina [UNESP] |
author_facet |
Nery, Marina [UNESP] Ferreira, Paula S. [UNESP] Gonçalves, Danielle R. [UNESP] Spolidorio, Luis C. [UNESP] Manthey, John A. Cesar, Thais B. [UNESP] |
author_role |
author |
author2 |
Ferreira, Paula S. [UNESP] Gonçalves, Danielle R. [UNESP] Spolidorio, Luis C. [UNESP] Manthey, John A. Cesar, Thais B. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) USDA |
dc.contributor.author.fl_str_mv |
Nery, Marina [UNESP] Ferreira, Paula S. [UNESP] Gonçalves, Danielle R. [UNESP] Spolidorio, Luis C. [UNESP] Manthey, John A. Cesar, Thais B. [UNESP] |
dc.subject.por.fl_str_mv |
citrus flavonoids inflammation metabolites obesity oxidative stress |
topic |
citrus flavonoids inflammation metabolites obesity oxidative stress |
description |
Two compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8-heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high-fat diet (HFD) in C57BL/6J mice. In the first 4 weeks, mice were fed either a standard diet (11% kcal from fat) for the control group, or a HFD (45% kcal from fat) to establish obesity in three experimental groups. In the following 4 weeks, two groups receiving the HFD were supplemented with either TAN or HMF at daily doses of 100 mg/kg body weight, while the two remaining groups continued to receive the standard healthy diet or the nonsupplemented HFD. Four weeks of supplementation with TAN and HMF resulted in intermediate levels of blood serum glucose, leptin, resistin, and insulin resistance compared with the healthy control and the nonsupplemented HFD groups. Blood serum peroxidation (TBARS) levels were significantly lower in the TAN and HMF groups compared with the nonsupplemented HFD group. Several differences occurred in the physiological effects of HMF versus TAN. TAN, but not HMF, reduced adipocyte size in the mice with pre-existent obesity, while HMF, but not TAN, decreased fat accumulation in the liver and also significantly increased the levels of an anti-inflammatory cytokine, IL-10. In an analysis of the metabolites of TAN and HMF, several main classes occurred, including a new set of methylglucuronide conjugates. It is suggested that contrasts between the observed physiological effects of TAN and HMF may be attributable to the differences in numbers and chemical structures of TAN and HMF metabolites. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:52:35Z 2021-06-25T10:52:35Z 2021-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/fsn3.2167 Food Science and Nutrition, v. 9, n. 4, p. 1997-2009, 2021. 2048-7177 http://hdl.handle.net/11449/207287 10.1002/fsn3.2167 2-s2.0-85100839449 |
url |
http://dx.doi.org/10.1002/fsn3.2167 http://hdl.handle.net/11449/207287 |
identifier_str_mv |
Food Science and Nutrition, v. 9, n. 4, p. 1997-2009, 2021. 2048-7177 10.1002/fsn3.2167 2-s2.0-85100839449 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food Science and Nutrition |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1997-2009 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128590146961408 |