Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.chemosphere.2020.127985 http://hdl.handle.net/11449/205156 |
Resumo: | Although banished in some countries, triclosan (TCS) and triclocarban (TCC) have been detected in surface waters in concentrations ranging from ng L−1 to μg L−1 and have shown to affect non-target organisms posing risk to aquatic ecosystems. However, the majority of the studies consider higher levels of these chemicals and single exposure effects to investigate their potential risks, rather than using environmentally relevant concentrations and their binary mixture. In this study, the toxicity of TCS and TCC, and their binary mixture was assessed in catfish embryos (Rhamdia quelen, a south American native species) exposed to environmental concentrations during 96 h. Organisms were evaluated through the endpoints of developmental abnormalities (spine, fin, facial/cranial and thorax), biochemical biomarkers related to oxidative stress responses: catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) activities, protein carbonylation (PCO) and neurotoxicity by acetylcholinesterase activity (AChE). The data showed that TCS caused fin abnormalities, decrease of SOD activity and increase of AChE activity in the catfish embryos of 96hpf. On the other hand, TCC and the binary mixture showed a higher abnormality index for the 96hpf embryos, and an induction of CAT and GST activities for the mixture treatment. The results obtained were able to show potential, but not severe, toxicity of TCS and TCC even in low concentrations and a short period of exposure. The relevance of studies approaching real scenarios of exposure should be reinforced, considering environmental concentrations of chemicals, interactions of contaminants in complex mixtures and the use of a native species such as R. quelen exposed during initial stages of development. |
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Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryosAntimicrobials environmental effectsBiochemical biomarkersEmbryo fish toxicityMixture assessmentOxidative stressAlthough banished in some countries, triclosan (TCS) and triclocarban (TCC) have been detected in surface waters in concentrations ranging from ng L−1 to μg L−1 and have shown to affect non-target organisms posing risk to aquatic ecosystems. However, the majority of the studies consider higher levels of these chemicals and single exposure effects to investigate their potential risks, rather than using environmentally relevant concentrations and their binary mixture. In this study, the toxicity of TCS and TCC, and their binary mixture was assessed in catfish embryos (Rhamdia quelen, a south American native species) exposed to environmental concentrations during 96 h. Organisms were evaluated through the endpoints of developmental abnormalities (spine, fin, facial/cranial and thorax), biochemical biomarkers related to oxidative stress responses: catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) activities, protein carbonylation (PCO) and neurotoxicity by acetylcholinesterase activity (AChE). The data showed that TCS caused fin abnormalities, decrease of SOD activity and increase of AChE activity in the catfish embryos of 96hpf. On the other hand, TCC and the binary mixture showed a higher abnormality index for the 96hpf embryos, and an induction of CAT and GST activities for the mixture treatment. The results obtained were able to show potential, but not severe, toxicity of TCS and TCC even in low concentrations and a short period of exposure. The relevance of studies approaching real scenarios of exposure should be reinforced, considering environmental concentrations of chemicals, interactions of contaminants in complex mixtures and the use of a native species such as R. quelen exposed during initial stages of development.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratory of Ecotoxicology Department of Chemistry and Biology Federal University of Technology - ParanáUniversidade do Sul de Santa CatarinaInstitute of Biosciences São Paulo State University (UNESP)Institute of Biosciences São Paulo State University (UNESP)FAPESP: 2016/15229-1Federal University of Technology - ParanáUniversidade do Sul de Santa CatarinaUniversidade Estadual Paulista (Unesp)Gomes, Monike Felipede Carvalho Soares de Paula, ViníciusRocha Martins, Lucia ReginaEsquivel Garcia, Juan RamonYamamoto, Flávia Yoshie [UNESP]Martins de Freitas, Adriane2021-06-25T10:10:48Z2021-06-25T10:10:48Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.chemosphere.2020.127985Chemosphere, v. 263.1879-12980045-6535http://hdl.handle.net/11449/20515610.1016/j.chemosphere.2020.1279852-s2.0-85089729152Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemosphereinfo:eu-repo/semantics/openAccess2021-10-23T10:54:49Zoai:repositorio.unesp.br:11449/205156Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:48:46.999744Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos |
title |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos |
spellingShingle |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos Gomes, Monike Felipe Antimicrobials environmental effects Biochemical biomarkers Embryo fish toxicity Mixture assessment Oxidative stress |
title_short |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos |
title_full |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos |
title_fullStr |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos |
title_full_unstemmed |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos |
title_sort |
Sublethal effects of triclosan and triclocarban at environmental concentrations in silver catfish (Rhamdia quelen) embryos |
author |
Gomes, Monike Felipe |
author_facet |
Gomes, Monike Felipe de Carvalho Soares de Paula, Vinícius Rocha Martins, Lucia Regina Esquivel Garcia, Juan Ramon Yamamoto, Flávia Yoshie [UNESP] Martins de Freitas, Adriane |
author_role |
author |
author2 |
de Carvalho Soares de Paula, Vinícius Rocha Martins, Lucia Regina Esquivel Garcia, Juan Ramon Yamamoto, Flávia Yoshie [UNESP] Martins de Freitas, Adriane |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Technology - Paraná Universidade do Sul de Santa Catarina Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Gomes, Monike Felipe de Carvalho Soares de Paula, Vinícius Rocha Martins, Lucia Regina Esquivel Garcia, Juan Ramon Yamamoto, Flávia Yoshie [UNESP] Martins de Freitas, Adriane |
dc.subject.por.fl_str_mv |
Antimicrobials environmental effects Biochemical biomarkers Embryo fish toxicity Mixture assessment Oxidative stress |
topic |
Antimicrobials environmental effects Biochemical biomarkers Embryo fish toxicity Mixture assessment Oxidative stress |
description |
Although banished in some countries, triclosan (TCS) and triclocarban (TCC) have been detected in surface waters in concentrations ranging from ng L−1 to μg L−1 and have shown to affect non-target organisms posing risk to aquatic ecosystems. However, the majority of the studies consider higher levels of these chemicals and single exposure effects to investigate their potential risks, rather than using environmentally relevant concentrations and their binary mixture. In this study, the toxicity of TCS and TCC, and their binary mixture was assessed in catfish embryos (Rhamdia quelen, a south American native species) exposed to environmental concentrations during 96 h. Organisms were evaluated through the endpoints of developmental abnormalities (spine, fin, facial/cranial and thorax), biochemical biomarkers related to oxidative stress responses: catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) activities, protein carbonylation (PCO) and neurotoxicity by acetylcholinesterase activity (AChE). The data showed that TCS caused fin abnormalities, decrease of SOD activity and increase of AChE activity in the catfish embryos of 96hpf. On the other hand, TCC and the binary mixture showed a higher abnormality index for the 96hpf embryos, and an induction of CAT and GST activities for the mixture treatment. The results obtained were able to show potential, but not severe, toxicity of TCS and TCC even in low concentrations and a short period of exposure. The relevance of studies approaching real scenarios of exposure should be reinforced, considering environmental concentrations of chemicals, interactions of contaminants in complex mixtures and the use of a native species such as R. quelen exposed during initial stages of development. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:10:48Z 2021-06-25T10:10:48Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.chemosphere.2020.127985 Chemosphere, v. 263. 1879-1298 0045-6535 http://hdl.handle.net/11449/205156 10.1016/j.chemosphere.2020.127985 2-s2.0-85089729152 |
url |
http://dx.doi.org/10.1016/j.chemosphere.2020.127985 http://hdl.handle.net/11449/205156 |
identifier_str_mv |
Chemosphere, v. 263. 1879-1298 0045-6535 10.1016/j.chemosphere.2020.127985 2-s2.0-85089729152 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemosphere |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128861627482112 |