Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/nu15092145 http://hdl.handle.net/11449/248815 |
Resumo: | The increase in life expectancy can be a consequence of the world’s socioeconomic, sanitary and nutritional conditions. Some studies have demonstrated that individuals with a satisfactory diet variety score present a lower risk of malnutrition and better health status. Zinc and selenium are important micronutrients that play a role in many biochemical and physiological processes of the immune system. Deficient individuals can present both innate and adaptive immunity abnormalities and increased susceptibility to infections. Primary immunodeficiency diseases, also known as inborn errors of immunity, are genetic disorders classically characterized by an increased susceptibility to infection and/or dysregulation of a specific immunologic pathway. IgA deficiency (IgAD) is the most common primary antibody deficiency. This disease is defined as serum IgA levels lower than 7 mg/dL and normal IgG and IgM levels in individuals older than four years. Although many patients are asymptomatic, selected patients suffer from different clinical complications, such as pulmonary infections, allergies, autoimmune diseases, gastrointestinal disorders and malignancy. Knowing the nutritional status as well as the risk of zinc and selenium deficiency could be helpful for the management of IgAD patients. Objectives: to investigate the anthropometric, biochemical, and nutritional profiles and the status of zinc and selenium in patients with IgAD. Methods: in this descriptive study, we screened 16 IgAD patients for anthropometric and dietary data, biochemical evaluation and determination of plasma and erythrocyte levels of zinc and selenium. Results: dietary intake of zinc and selenium was adequate in 75% and 86% of the patients, respectively. These results were consistent with the plasma levels (adequate levels of zinc in all patients and selenium in 50% of children, 25% of adolescents and 100% of adults). However, erythrocyte levels were low for both micronutrients (deficiency for both in 100% of children, 75% of adolescents and 25% of adults). Conclusion: our results highlight the elevated prevalence of erythrocyte zinc and selenium deficiency in patients with IgAD, and the need for investigation of these micronutrients in their follow-up. |
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Proposal to Screen for Zinc and Selenium in Patients with IgA DeficiencyIgA deficiencyimmune systemrecommended dietary allowancesselenium deficiencyzinc deficiencyThe increase in life expectancy can be a consequence of the world’s socioeconomic, sanitary and nutritional conditions. Some studies have demonstrated that individuals with a satisfactory diet variety score present a lower risk of malnutrition and better health status. Zinc and selenium are important micronutrients that play a role in many biochemical and physiological processes of the immune system. Deficient individuals can present both innate and adaptive immunity abnormalities and increased susceptibility to infections. Primary immunodeficiency diseases, also known as inborn errors of immunity, are genetic disorders classically characterized by an increased susceptibility to infection and/or dysregulation of a specific immunologic pathway. IgA deficiency (IgAD) is the most common primary antibody deficiency. This disease is defined as serum IgA levels lower than 7 mg/dL and normal IgG and IgM levels in individuals older than four years. Although many patients are asymptomatic, selected patients suffer from different clinical complications, such as pulmonary infections, allergies, autoimmune diseases, gastrointestinal disorders and malignancy. Knowing the nutritional status as well as the risk of zinc and selenium deficiency could be helpful for the management of IgAD patients. Objectives: to investigate the anthropometric, biochemical, and nutritional profiles and the status of zinc and selenium in patients with IgAD. Methods: in this descriptive study, we screened 16 IgAD patients for anthropometric and dietary data, biochemical evaluation and determination of plasma and erythrocyte levels of zinc and selenium. Results: dietary intake of zinc and selenium was adequate in 75% and 86% of the patients, respectively. These results were consistent with the plasma levels (adequate levels of zinc in all patients and selenium in 50% of children, 25% of adolescents and 100% of adults). However, erythrocyte levels were low for both micronutrients (deficiency for both in 100% of children, 75% of adolescents and 25% of adults). Conclusion: our results highlight the elevated prevalence of erythrocyte zinc and selenium deficiency in patients with IgAD, and the need for investigation of these micronutrients in their follow-up.Department of Pediatrics Ribeirão Preto Medical School University of São Paulo FMRP/USPDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences São Paulo State University UNESPLaboratory of Toxicology and Metal Essentiality Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo—USPDepartment of Health Sciences Division of Nutrition and Metabolism Ribeirão Preto Medical School University of São Paulo—FMRP/USPDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences São Paulo State University UNESPUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Abu Jamra, Soraya ReginaKomatsu, Camila Gomes [UNESP]Barbosa, FernandoRoxo-Junior, PersioNavarro, Anderson Marliere2023-07-29T13:54:30Z2023-07-29T13:54:30Z2023-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/nu15092145Nutrients, v. 15, n. 9, 2023.2072-6643http://hdl.handle.net/11449/24881510.3390/nu150921452-s2.0-85159096002Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrientsinfo:eu-repo/semantics/openAccess2023-07-29T13:54:30Zoai:repositorio.unesp.br:11449/248815Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:54:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency |
title |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency |
spellingShingle |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency Abu Jamra, Soraya Regina IgA deficiency immune system recommended dietary allowances selenium deficiency zinc deficiency |
title_short |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency |
title_full |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency |
title_fullStr |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency |
title_full_unstemmed |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency |
title_sort |
Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency |
author |
Abu Jamra, Soraya Regina |
author_facet |
Abu Jamra, Soraya Regina Komatsu, Camila Gomes [UNESP] Barbosa, Fernando Roxo-Junior, Persio Navarro, Anderson Marliere |
author_role |
author |
author2 |
Komatsu, Camila Gomes [UNESP] Barbosa, Fernando Roxo-Junior, Persio Navarro, Anderson Marliere |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Abu Jamra, Soraya Regina Komatsu, Camila Gomes [UNESP] Barbosa, Fernando Roxo-Junior, Persio Navarro, Anderson Marliere |
dc.subject.por.fl_str_mv |
IgA deficiency immune system recommended dietary allowances selenium deficiency zinc deficiency |
topic |
IgA deficiency immune system recommended dietary allowances selenium deficiency zinc deficiency |
description |
The increase in life expectancy can be a consequence of the world’s socioeconomic, sanitary and nutritional conditions. Some studies have demonstrated that individuals with a satisfactory diet variety score present a lower risk of malnutrition and better health status. Zinc and selenium are important micronutrients that play a role in many biochemical and physiological processes of the immune system. Deficient individuals can present both innate and adaptive immunity abnormalities and increased susceptibility to infections. Primary immunodeficiency diseases, also known as inborn errors of immunity, are genetic disorders classically characterized by an increased susceptibility to infection and/or dysregulation of a specific immunologic pathway. IgA deficiency (IgAD) is the most common primary antibody deficiency. This disease is defined as serum IgA levels lower than 7 mg/dL and normal IgG and IgM levels in individuals older than four years. Although many patients are asymptomatic, selected patients suffer from different clinical complications, such as pulmonary infections, allergies, autoimmune diseases, gastrointestinal disorders and malignancy. Knowing the nutritional status as well as the risk of zinc and selenium deficiency could be helpful for the management of IgAD patients. Objectives: to investigate the anthropometric, biochemical, and nutritional profiles and the status of zinc and selenium in patients with IgAD. Methods: in this descriptive study, we screened 16 IgAD patients for anthropometric and dietary data, biochemical evaluation and determination of plasma and erythrocyte levels of zinc and selenium. Results: dietary intake of zinc and selenium was adequate in 75% and 86% of the patients, respectively. These results were consistent with the plasma levels (adequate levels of zinc in all patients and selenium in 50% of children, 25% of adolescents and 100% of adults). However, erythrocyte levels were low for both micronutrients (deficiency for both in 100% of children, 75% of adolescents and 25% of adults). Conclusion: our results highlight the elevated prevalence of erythrocyte zinc and selenium deficiency in patients with IgAD, and the need for investigation of these micronutrients in their follow-up. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:54:30Z 2023-07-29T13:54:30Z 2023-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/nu15092145 Nutrients, v. 15, n. 9, 2023. 2072-6643 http://hdl.handle.net/11449/248815 10.3390/nu15092145 2-s2.0-85159096002 |
url |
http://dx.doi.org/10.3390/nu15092145 http://hdl.handle.net/11449/248815 |
identifier_str_mv |
Nutrients, v. 15, n. 9, 2023. 2072-6643 10.3390/nu15092145 2-s2.0-85159096002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrients |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964764624912384 |