Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study

Detalhes bibliográficos
Autor(a) principal: Brandini, Daniela Atili [UNESP]
Data de Publicação: 2005
Outros Autores: Sala, Miguel Angel, Lopes, Ruberval Armando, Semprini, Marisa, Contrera, Mary Garcia Duarte
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0103-64402005000100011
http://hdl.handle.net/11449/68088
Resumo: The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel' s cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.
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spelling Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic studyCigarette smokeMeckel's cartilageMorphometryRat fetusanimalcartilagefemalefetus weightindoor air pollutionintrauterine growth retardationmandibleorganogenesispathologyplacentapregnancyprenatal developmentratthree dimensional imagingWistar ratAnimalsCartilageFemaleFetal Growth RetardationFetal WeightImaging, Three-DimensionalMandibleOrganogenesisPlacentaPregnancyRatsRats, WistarTobacco Smoke PollutionThe purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel' s cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.Department of Surgery and Integrated Clinics Faculty of Dentistry of Araçatuba São Paulo State University (UNESP), Araçatuba, SPDepartment of Morphology, Stomatology and Physiology Faculty of Dentistry of Ribeirão Preto University of São Paulo (USP), Ribeirão Preto, SPUniversity of Franca (UNIFRAN), Franca, SPDepartamento de Morfologia, Estomatologia e Fisiologia Laboratório de Patologia USP, 14040-904 Ribeirão Preto, SPDepartment of Surgery and Integrated Clinics Faculty of Dentistry of Araçatuba São Paulo State University (UNESP), Araçatuba, SPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)University of Franca (UNIFRAN)Brandini, Daniela Atili [UNESP]Sala, Miguel AngelLopes, Ruberval ArmandoSemprini, MarisaContrera, Mary Garcia Duarte2014-05-27T11:21:15Z2014-05-27T11:21:15Z2005-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article62-66application/pdfhttp://dx.doi.org/10.1590/S0103-64402005000100011Brazilian Dental Journal, v. 16, n. 1, p. 62-66, 2005.0103-6440http://hdl.handle.net/11449/6808810.1590/S0103-64402005000100011S0103-644020050001000112-s2.0-284444698262-s2.0-28444469826.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Dental Journal0,476info:eu-repo/semantics/openAccess2023-11-10T06:15:33Zoai:repositorio.unesp.br:11449/68088Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:20:55.054885Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
title Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
spellingShingle Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
Brandini, Daniela Atili [UNESP]
Cigarette smoke
Meckel's cartilage
Morphometry
Rat fetus
animal
cartilage
female
fetus weight
indoor air pollution
intrauterine growth retardation
mandible
organogenesis
pathology
placenta
pregnancy
prenatal development
rat
three dimensional imaging
Wistar rat
Animals
Cartilage
Female
Fetal Growth Retardation
Fetal Weight
Imaging, Three-Dimensional
Mandible
Organogenesis
Placenta
Pregnancy
Rats
Rats, Wistar
Tobacco Smoke Pollution
title_short Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
title_full Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
title_fullStr Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
title_full_unstemmed Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
title_sort Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
author Brandini, Daniela Atili [UNESP]
author_facet Brandini, Daniela Atili [UNESP]
Sala, Miguel Angel
Lopes, Ruberval Armando
Semprini, Marisa
Contrera, Mary Garcia Duarte
author_role author
author2 Sala, Miguel Angel
Lopes, Ruberval Armando
Semprini, Marisa
Contrera, Mary Garcia Duarte
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
University of Franca (UNIFRAN)
dc.contributor.author.fl_str_mv Brandini, Daniela Atili [UNESP]
Sala, Miguel Angel
Lopes, Ruberval Armando
Semprini, Marisa
Contrera, Mary Garcia Duarte
dc.subject.por.fl_str_mv Cigarette smoke
Meckel's cartilage
Morphometry
Rat fetus
animal
cartilage
female
fetus weight
indoor air pollution
intrauterine growth retardation
mandible
organogenesis
pathology
placenta
pregnancy
prenatal development
rat
three dimensional imaging
Wistar rat
Animals
Cartilage
Female
Fetal Growth Retardation
Fetal Weight
Imaging, Three-Dimensional
Mandible
Organogenesis
Placenta
Pregnancy
Rats
Rats, Wistar
Tobacco Smoke Pollution
topic Cigarette smoke
Meckel's cartilage
Morphometry
Rat fetus
animal
cartilage
female
fetus weight
indoor air pollution
intrauterine growth retardation
mandible
organogenesis
pathology
placenta
pregnancy
prenatal development
rat
three dimensional imaging
Wistar rat
Animals
Cartilage
Female
Fetal Growth Retardation
Fetal Weight
Imaging, Three-Dimensional
Mandible
Organogenesis
Placenta
Pregnancy
Rats
Rats, Wistar
Tobacco Smoke Pollution
description The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel' s cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.
publishDate 2005
dc.date.none.fl_str_mv 2005-01-01
2014-05-27T11:21:15Z
2014-05-27T11:21:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-64402005000100011
Brazilian Dental Journal, v. 16, n. 1, p. 62-66, 2005.
0103-6440
http://hdl.handle.net/11449/68088
10.1590/S0103-64402005000100011
S0103-64402005000100011
2-s2.0-28444469826
2-s2.0-28444469826.pdf
url http://dx.doi.org/10.1590/S0103-64402005000100011
http://hdl.handle.net/11449/68088
identifier_str_mv Brazilian Dental Journal, v. 16, n. 1, p. 62-66, 2005.
0103-6440
10.1590/S0103-64402005000100011
S0103-64402005000100011
2-s2.0-28444469826
2-s2.0-28444469826.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Dental Journal
0,476
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 62-66
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128795514765312

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