Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis?
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992008000400015 http://hdl.handle.net/11449/225372 |
Resumo: | The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 μg/g in the liver and 51.2 μg/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one. |
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Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis?Copper toxicosisCrotalic venomDifferential diagnosisHyperimmunizationOvinesThe unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 μg/g in the liver and 51.2 μg/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one.Department of Tropical Diseases Botucatu Medical School São Paulo State University, Botucatu, São Paulo StateCenter for the Study of Venoms and Venomous Animals CEVAP São Paulo State University, Botucatu, São Paulo StateRadiobiology Supervision Nuclear Energy Research Institute IPEN/CNEN-SP, São Paulo, São Paulo StateClinical Laboratory of Veterinary Veterinary Medicine and Animal Husbandry School São Paulo State University, Botucatu, São Paulo StateCentro de Estudos de Venenos e Animais Peçonhentos CEVAP UNESP, Caixa Postal 577, Botucatu, SP, 18618-000, BrasilDepartment of Tropical Diseases Botucatu Medical School São Paulo State University, Botucatu, São Paulo StateCenter for the Study of Venoms and Venomous Animals CEVAP São Paulo State University, Botucatu, São Paulo StateClinical Laboratory of Veterinary Veterinary Medicine and Animal Husbandry School São Paulo State University, Botucatu, São Paulo StateCentro de Estudos de Venenos e Animais Peçonhentos CEVAP UNESP, Caixa Postal 577, Botucatu, SP, 18618-000, BrasilUniversidade Estadual Paulista (UNESP)IPEN/CNEN-SPFerreira Junior, R. S. [UNESP]Nascimento, N.Couto, R. [UNESP]Alves, J. B.Meira, D. A. [UNESP]Barraviera, B. [UNESP]2022-04-28T20:48:11Z2022-04-28T20:48:11Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article738-749http://dx.doi.org/10.1590/S1678-91992008000400015Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 4, p. 738-749, 2008.1678-9199http://hdl.handle.net/11449/22537210.1590/S1678-919920080004000152-s2.0-58049154396Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2022-04-28T20:48:11Zoai:repositorio.unesp.br:11449/225372Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T20:48:11Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? |
title |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? |
spellingShingle |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? Ferreira Junior, R. S. [UNESP] Copper toxicosis Crotalic venom Differential diagnosis Hyperimmunization Ovines |
title_short |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? |
title_full |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? |
title_fullStr |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? |
title_full_unstemmed |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? |
title_sort |
Young ovine death during hyperimmunization: Crotalic envenomation or copper toxicosis? |
author |
Ferreira Junior, R. S. [UNESP] |
author_facet |
Ferreira Junior, R. S. [UNESP] Nascimento, N. Couto, R. [UNESP] Alves, J. B. Meira, D. A. [UNESP] Barraviera, B. [UNESP] |
author_role |
author |
author2 |
Nascimento, N. Couto, R. [UNESP] Alves, J. B. Meira, D. A. [UNESP] Barraviera, B. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) IPEN/CNEN-SP |
dc.contributor.author.fl_str_mv |
Ferreira Junior, R. S. [UNESP] Nascimento, N. Couto, R. [UNESP] Alves, J. B. Meira, D. A. [UNESP] Barraviera, B. [UNESP] |
dc.subject.por.fl_str_mv |
Copper toxicosis Crotalic venom Differential diagnosis Hyperimmunization Ovines |
topic |
Copper toxicosis Crotalic venom Differential diagnosis Hyperimmunization Ovines |
description |
The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 μg/g in the liver and 51.2 μg/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 2022-04-28T20:48:11Z 2022-04-28T20:48:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992008000400015 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 4, p. 738-749, 2008. 1678-9199 http://hdl.handle.net/11449/225372 10.1590/S1678-91992008000400015 2-s2.0-58049154396 |
url |
http://dx.doi.org/10.1590/S1678-91992008000400015 http://hdl.handle.net/11449/225372 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 4, p. 738-749, 2008. 1678-9199 10.1590/S1678-91992008000400015 2-s2.0-58049154396 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
738-749 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965395791118336 |