Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992008000400015 http://hdl.handle.net/11449/11843 |
Resumo: | The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 mu g/g in the liver and 51.2 mu g/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one. |
id |
UNSP_7faba1a268b4cb6505a12e6fbb9d31e5 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/11843 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?differential diagnosiscopper toxicosisovinescrotalic venomhyperimmunizationThe unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 mu g/g in the liver and 51.2 mu g/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one.São Paulo State Univ, CEVAP, UNESP, Ctr Study Venoms & Venomous Anim, BR-18618000 Botucatu, SP, BrazilSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Trop Dis, BR-18618000 Botucatu, SP, BrazilIPEN CNEN SP, Inst Nucl Energy Res, São Paulo, BrazilSão Paulo State Univ, UNESP, Clin Lab Vet, Vet Med & Anim Husb Sch, BR-18618000 Botucatu, SP, BrazilSão Paulo State Univ, CEVAP, UNESP, Ctr Study Venoms & Venomous Anim, BR-18618000 Botucatu, SP, BrazilSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Trop Dis, BR-18618000 Botucatu, SP, BrazilSão Paulo State Univ, UNESP, Clin Lab Vet, Vet Med & Anim Husb Sch, BR-18618000 Botucatu, SP, BrazilUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)Universidade Estadual Paulista (Unesp)Instituto de Pesquisas Energéticas e Nucleares (IPEN)Ferreira Júnior, Rui Seabra [UNESP]Nascimento, N.Couto, R. [UNESP]Alves, J. B.Meira, D. A. [UNESP]Barraviera, Benedito [UNESP]2014-05-20T13:34:31Z2014-05-20T13:34:31Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article738-749application/pdfhttp://dx.doi.org/10.1590/S1678-91992008000400015Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 4, p. 738-749, 2008.1678-9199http://hdl.handle.net/11449/11843S1678-91992008000400015WOS:000267352500015S1678-91992008000400015-en.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2024-08-15T15:22:47Zoai:repositorio.unesp.br:11449/11843Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:22:47Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
spellingShingle |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? Ferreira Júnior, Rui Seabra [UNESP] differential diagnosis copper toxicosis ovines crotalic venom hyperimmunization |
title_short |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_full |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_fullStr |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_full_unstemmed |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
title_sort |
Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? |
author |
Ferreira Júnior, Rui Seabra [UNESP] |
author_facet |
Ferreira Júnior, Rui Seabra [UNESP] Nascimento, N. Couto, R. [UNESP] Alves, J. B. Meira, D. A. [UNESP] Barraviera, Benedito [UNESP] |
author_role |
author |
author2 |
Nascimento, N. Couto, R. [UNESP] Alves, J. B. Meira, D. A. [UNESP] Barraviera, Benedito [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
dc.contributor.author.fl_str_mv |
Ferreira Júnior, Rui Seabra [UNESP] Nascimento, N. Couto, R. [UNESP] Alves, J. B. Meira, D. A. [UNESP] Barraviera, Benedito [UNESP] |
dc.subject.por.fl_str_mv |
differential diagnosis copper toxicosis ovines crotalic venom hyperimmunization |
topic |
differential diagnosis copper toxicosis ovines crotalic venom hyperimmunization |
description |
The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 mu g/g in the liver and 51.2 mu g/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 2014-05-20T13:34:31Z 2014-05-20T13:34:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992008000400015 Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 4, p. 738-749, 2008. 1678-9199 http://hdl.handle.net/11449/11843 S1678-91992008000400015 WOS:000267352500015 S1678-91992008000400015-en.pdf |
url |
http://dx.doi.org/10.1590/S1678-91992008000400015 http://hdl.handle.net/11449/11843 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 4, p. 738-749, 2008. 1678-9199 S1678-91992008000400015 WOS:000267352500015 S1678-91992008000400015-en.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases 1.782 0,573 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
738-749 application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128136599044096 |