Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00784-016-1909-x http://hdl.handle.net/11449/173305 |
Resumo: | Objectives: The aim of this study is to evaluate the alendronate and raloxifene influence in the alveolar healing process of osteoporotic rats. Materials and methods: Sixty-four female rats were divided in four groups: sham rats (SHAM), ovariectomized rats and no medical treatment (OVX NT), ovariectomized rats and submitted to alendronate treatment (OVX ALE), and ovariectomized and submitted to raloxifene treatment (OVX RAL). The histomorphometrical and immunohistochemical analysis was performed. The quantitative data were analyzed through Kruskal-Wallis and Dunn tests (α = 0.05). Results: In the longest period, SHAM and OVX RAL groups showed the better bone formation responses (P < 0.05). The worst bone formation response was observed in the group OVX NT. OVX RAL group showed the better response at 42 days. OVX ALE group showed a favorable response at 14 days, in comparison with OVX RAL group, but a reduced response at 42 days. It was possible to observe a mature bone in SHAM group at 14 days and an immature bone in the OVX NT group. An intermediate quality bone was observed in the groups OVX ALE and OVX RAL. Conclusion: Alendronate and raloxifene treatment improved the alveolar healing process in osteoporotic rats, but not enough to achieve the histometrical and protein expression values that were observed in the SHAM group. Clinical relevance: Alendronate is largely used as a potent antiresorptive agent. Otherwise, considering the undesirable effects in relation to the alveolar healing, other antiosteoporosis medications should be studied. Raloxifene seems to be a good candidate once its action mechanism involves the activation of osteoblasts. |
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Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized ratsAlendronateOsteocalcinOsteoprotegerinRaloxifeneRANKLObjectives: The aim of this study is to evaluate the alendronate and raloxifene influence in the alveolar healing process of osteoporotic rats. Materials and methods: Sixty-four female rats were divided in four groups: sham rats (SHAM), ovariectomized rats and no medical treatment (OVX NT), ovariectomized rats and submitted to alendronate treatment (OVX ALE), and ovariectomized and submitted to raloxifene treatment (OVX RAL). The histomorphometrical and immunohistochemical analysis was performed. The quantitative data were analyzed through Kruskal-Wallis and Dunn tests (α = 0.05). Results: In the longest period, SHAM and OVX RAL groups showed the better bone formation responses (P < 0.05). The worst bone formation response was observed in the group OVX NT. OVX RAL group showed the better response at 42 days. OVX ALE group showed a favorable response at 14 days, in comparison with OVX RAL group, but a reduced response at 42 days. It was possible to observe a mature bone in SHAM group at 14 days and an immature bone in the OVX NT group. An intermediate quality bone was observed in the groups OVX ALE and OVX RAL. Conclusion: Alendronate and raloxifene treatment improved the alveolar healing process in osteoporotic rats, but not enough to achieve the histometrical and protein expression values that were observed in the SHAM group. Clinical relevance: Alendronate is largely used as a potent antiresorptive agent. Otherwise, considering the undesirable effects in relation to the alveolar healing, other antiosteoporosis medications should be studied. Raloxifene seems to be a good candidate once its action mechanism involves the activation of osteoblasts.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Surgery and Integrated Clinic Division of Oral and Maxillofacial Surgery Aracatuba Dental School Universidade Estadual Paulista (UNESP), Rua José Bonifácio, 1193, CEP 16015-050, AraçatubaDepartment of Basic Sciences Aracatuba Dental School Universidade Estadual Paulista (UNESP)Department of Surgery and Integrated Clinic Division of Oral and Maxillofacial Surgery Aracatuba Dental School Universidade Estadual Paulista (UNESP), Rua José Bonifácio, 1193, CEP 16015-050, AraçatubaDepartment of Basic Sciences Aracatuba Dental School Universidade Estadual Paulista (UNESP)FAPESP: 2010/04366-1Universidade Estadual Paulista (Unesp)Ramalho-Ferreira, Gabriel [UNESP]Faverani, Leonardo Perez [UNESP]Momesso, Gustavo Antonio Correa [UNESP]Luvizuto, Eloá Rodrigues [UNESP]de Oliveira Puttini, Igor [UNESP]Okamoto, Roberta [UNESP]2018-12-11T17:04:35Z2018-12-11T17:04:35Z2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1485-1494application/pdfhttp://dx.doi.org/10.1007/s00784-016-1909-xClinical Oral Investigations, v. 21, n. 5, p. 1485-1494, 2017.1436-37711432-6981http://hdl.handle.net/11449/17330510.1007/s00784-016-1909-x2-s2.0-849797107352-s2.0-84979710735.pdf1527011976590326Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Oral Investigations0,9860,986info:eu-repo/semantics/openAccess2024-01-24T06:31:01Zoai:repositorio.unesp.br:11449/173305Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-24T06:31:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats |
title |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats |
spellingShingle |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats Ramalho-Ferreira, Gabriel [UNESP] Alendronate Osteocalcin Osteoprotegerin Raloxifene RANKL |
title_short |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats |
title_full |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats |
title_fullStr |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats |
title_full_unstemmed |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats |
title_sort |
Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats |
author |
Ramalho-Ferreira, Gabriel [UNESP] |
author_facet |
Ramalho-Ferreira, Gabriel [UNESP] Faverani, Leonardo Perez [UNESP] Momesso, Gustavo Antonio Correa [UNESP] Luvizuto, Eloá Rodrigues [UNESP] de Oliveira Puttini, Igor [UNESP] Okamoto, Roberta [UNESP] |
author_role |
author |
author2 |
Faverani, Leonardo Perez [UNESP] Momesso, Gustavo Antonio Correa [UNESP] Luvizuto, Eloá Rodrigues [UNESP] de Oliveira Puttini, Igor [UNESP] Okamoto, Roberta [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ramalho-Ferreira, Gabriel [UNESP] Faverani, Leonardo Perez [UNESP] Momesso, Gustavo Antonio Correa [UNESP] Luvizuto, Eloá Rodrigues [UNESP] de Oliveira Puttini, Igor [UNESP] Okamoto, Roberta [UNESP] |
dc.subject.por.fl_str_mv |
Alendronate Osteocalcin Osteoprotegerin Raloxifene RANKL |
topic |
Alendronate Osteocalcin Osteoprotegerin Raloxifene RANKL |
description |
Objectives: The aim of this study is to evaluate the alendronate and raloxifene influence in the alveolar healing process of osteoporotic rats. Materials and methods: Sixty-four female rats were divided in four groups: sham rats (SHAM), ovariectomized rats and no medical treatment (OVX NT), ovariectomized rats and submitted to alendronate treatment (OVX ALE), and ovariectomized and submitted to raloxifene treatment (OVX RAL). The histomorphometrical and immunohistochemical analysis was performed. The quantitative data were analyzed through Kruskal-Wallis and Dunn tests (α = 0.05). Results: In the longest period, SHAM and OVX RAL groups showed the better bone formation responses (P < 0.05). The worst bone formation response was observed in the group OVX NT. OVX RAL group showed the better response at 42 days. OVX ALE group showed a favorable response at 14 days, in comparison with OVX RAL group, but a reduced response at 42 days. It was possible to observe a mature bone in SHAM group at 14 days and an immature bone in the OVX NT group. An intermediate quality bone was observed in the groups OVX ALE and OVX RAL. Conclusion: Alendronate and raloxifene treatment improved the alveolar healing process in osteoporotic rats, but not enough to achieve the histometrical and protein expression values that were observed in the SHAM group. Clinical relevance: Alendronate is largely used as a potent antiresorptive agent. Otherwise, considering the undesirable effects in relation to the alveolar healing, other antiosteoporosis medications should be studied. Raloxifene seems to be a good candidate once its action mechanism involves the activation of osteoblasts. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 2018-12-11T17:04:35Z 2018-12-11T17:04:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00784-016-1909-x Clinical Oral Investigations, v. 21, n. 5, p. 1485-1494, 2017. 1436-3771 1432-6981 http://hdl.handle.net/11449/173305 10.1007/s00784-016-1909-x 2-s2.0-84979710735 2-s2.0-84979710735.pdf 1527011976590326 |
url |
http://dx.doi.org/10.1007/s00784-016-1909-x http://hdl.handle.net/11449/173305 |
identifier_str_mv |
Clinical Oral Investigations, v. 21, n. 5, p. 1485-1494, 2017. 1436-3771 1432-6981 10.1007/s00784-016-1909-x 2-s2.0-84979710735 2-s2.0-84979710735.pdf 1527011976590326 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Oral Investigations 0,986 0,986 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1485-1494 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965712490430464 |