Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol

Detalhes bibliográficos
Autor(a) principal: De Castro, Marines [UNESP]
Data de Publicação: 2009
Outros Autores: Veiga, Angela P. M., Pacheco, Maria R. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://jrnlappliedresearch.com/articles/Vol9Iss1/deCastroVol9No1.pdf
http://hdl.handle.net/11449/71106
Resumo: Hyperlipidemia is well recognized as an important risk factor in the development of atherosclerosis. Low-density lipoproteins (LDL) are components of cholesterol that are highly associated to an increased risk of cardiovascular diseases. Hypercholesterolemia induces proteolytic and oxidative changes in vasculature, leading to a local inflammatory response. Since dietary antioxidants have attracted considerable attention as preventive and therapeutic agents, the polyphenolic compound resveratrol seems to play an important role in prevention of human atherosclerosis. Researches show that resveratrol inhibits LDL oxidation and platelet aggregation, as well as vascular prolifer ation of smooth muscle cells. However, recent findings in animal models reveal conflicting results regarding its effects on plasma lipid levels. The aim of the present study was to evaluate the effect of resveratrol on plasma biochemistry profile in New Zealand white rabbits submitted to a hypercholesterolemic diet. Twenty healthy, male, adult New Zealand white rabbits were fed with ordinary diet for one week before being divided into four treatment groups, containing five animals each. Group CT received maintenance diet; group R received maintenance diet and resveratrol (3mg/kg/day) given orally; group CL received maintenance diet enriched with 1.5% cholesterol; and group CR received maintenance diet enriched with 1.5% cholesterol and resveratrol (3mg/kg/day) given orally. During the experiment, from each animal, samples of 3mL venous blood were collected in heparin twice monthly for measurements of total cholesterol, triglycerides, and low- and high-density lipoproteins. The data analysis revealed that resveratrol did not have a hypolipidemic effect in experimentally induced hypercholesterolemic New Zealand white rabbits.
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spelling Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrolAtherosclerosisHyperlipidemiaResveratrolcholesterolheparinhigh density lipoproteinlow density lipoproteinresveratroltriacylglycerolanimal experimentanimal modelblood samplingcholesterol blood levelcontrolled studydrug effecthyperlipidemialipid blood levelmaleNew ZealandnonhumanrabbitHyperlipidemia is well recognized as an important risk factor in the development of atherosclerosis. Low-density lipoproteins (LDL) are components of cholesterol that are highly associated to an increased risk of cardiovascular diseases. Hypercholesterolemia induces proteolytic and oxidative changes in vasculature, leading to a local inflammatory response. Since dietary antioxidants have attracted considerable attention as preventive and therapeutic agents, the polyphenolic compound resveratrol seems to play an important role in prevention of human atherosclerosis. Researches show that resveratrol inhibits LDL oxidation and platelet aggregation, as well as vascular prolifer ation of smooth muscle cells. However, recent findings in animal models reveal conflicting results regarding its effects on plasma lipid levels. The aim of the present study was to evaluate the effect of resveratrol on plasma biochemistry profile in New Zealand white rabbits submitted to a hypercholesterolemic diet. Twenty healthy, male, adult New Zealand white rabbits were fed with ordinary diet for one week before being divided into four treatment groups, containing five animals each. Group CT received maintenance diet; group R received maintenance diet and resveratrol (3mg/kg/day) given orally; group CL received maintenance diet enriched with 1.5% cholesterol; and group CR received maintenance diet enriched with 1.5% cholesterol and resveratrol (3mg/kg/day) given orally. During the experiment, from each animal, samples of 3mL venous blood were collected in heparin twice monthly for measurements of total cholesterol, triglycerides, and low- and high-density lipoproteins. The data analysis revealed that resveratrol did not have a hypolipidemic effect in experimentally induced hypercholesterolemic New Zealand white rabbits.São Paulo State University, Jaboticabal, SPFederal University of Rio Grande do Sul, Porto Alegre, RSUniversidade Estadual Paulista (UNESP) Faculty of Agricultural and Veterinary Sciences Department of Morphology, Via de Acesso Prof. Paulo Donato Castellane, s/n, Jaboticabal, São Paulo, 14884-900São Paulo State University, Jaboticabal, SPUniversidade Estadual Paulista (UNESP) Faculty of Agricultural and Veterinary Sciences Department of Morphology, Via de Acesso Prof. Paulo Donato Castellane, s/n, Jaboticabal, São Paulo, 14884-900Universidade Estadual Paulista (Unesp)Federal University of Rio Grande do SulDe Castro, Marines [UNESP]Veiga, Angela P. M.Pacheco, Maria R. [UNESP]2014-05-27T11:23:57Z2014-05-27T11:23:57Z2009-08-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article18-22http://jrnlappliedresearch.com/articles/Vol9Iss1/deCastroVol9No1.pdfJournal of Applied Research, v. 9, n. 1-2, p. 18-22, 2009.1537-064Xhttp://hdl.handle.net/11449/711062-s2.0-68249141402Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Researchinfo:eu-repo/semantics/openAccess2024-06-06T18:41:54Zoai:repositorio.unesp.br:11449/71106Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:35:28.291075Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
title Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
spellingShingle Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
De Castro, Marines [UNESP]
Atherosclerosis
Hyperlipidemia
Resveratrol
cholesterol
heparin
high density lipoprotein
low density lipoprotein
resveratrol
triacylglycerol
animal experiment
animal model
blood sampling
cholesterol blood level
controlled study
drug effect
hyperlipidemia
lipid blood level
male
New Zealand
nonhuman
rabbit
title_short Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
title_full Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
title_fullStr Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
title_full_unstemmed Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
title_sort Plasma lipid profile of experimentally induced hyperlipidemic New Zealand white rabbits is not affected by resveratrol
author De Castro, Marines [UNESP]
author_facet De Castro, Marines [UNESP]
Veiga, Angela P. M.
Pacheco, Maria R. [UNESP]
author_role author
author2 Veiga, Angela P. M.
Pacheco, Maria R. [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Federal University of Rio Grande do Sul
dc.contributor.author.fl_str_mv De Castro, Marines [UNESP]
Veiga, Angela P. M.
Pacheco, Maria R. [UNESP]
dc.subject.por.fl_str_mv Atherosclerosis
Hyperlipidemia
Resveratrol
cholesterol
heparin
high density lipoprotein
low density lipoprotein
resveratrol
triacylglycerol
animal experiment
animal model
blood sampling
cholesterol blood level
controlled study
drug effect
hyperlipidemia
lipid blood level
male
New Zealand
nonhuman
rabbit
topic Atherosclerosis
Hyperlipidemia
Resveratrol
cholesterol
heparin
high density lipoprotein
low density lipoprotein
resveratrol
triacylglycerol
animal experiment
animal model
blood sampling
cholesterol blood level
controlled study
drug effect
hyperlipidemia
lipid blood level
male
New Zealand
nonhuman
rabbit
description Hyperlipidemia is well recognized as an important risk factor in the development of atherosclerosis. Low-density lipoproteins (LDL) are components of cholesterol that are highly associated to an increased risk of cardiovascular diseases. Hypercholesterolemia induces proteolytic and oxidative changes in vasculature, leading to a local inflammatory response. Since dietary antioxidants have attracted considerable attention as preventive and therapeutic agents, the polyphenolic compound resveratrol seems to play an important role in prevention of human atherosclerosis. Researches show that resveratrol inhibits LDL oxidation and platelet aggregation, as well as vascular prolifer ation of smooth muscle cells. However, recent findings in animal models reveal conflicting results regarding its effects on plasma lipid levels. The aim of the present study was to evaluate the effect of resveratrol on plasma biochemistry profile in New Zealand white rabbits submitted to a hypercholesterolemic diet. Twenty healthy, male, adult New Zealand white rabbits were fed with ordinary diet for one week before being divided into four treatment groups, containing five animals each. Group CT received maintenance diet; group R received maintenance diet and resveratrol (3mg/kg/day) given orally; group CL received maintenance diet enriched with 1.5% cholesterol; and group CR received maintenance diet enriched with 1.5% cholesterol and resveratrol (3mg/kg/day) given orally. During the experiment, from each animal, samples of 3mL venous blood were collected in heparin twice monthly for measurements of total cholesterol, triglycerides, and low- and high-density lipoproteins. The data analysis revealed that resveratrol did not have a hypolipidemic effect in experimentally induced hypercholesterolemic New Zealand white rabbits.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-12
2014-05-27T11:23:57Z
2014-05-27T11:23:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://jrnlappliedresearch.com/articles/Vol9Iss1/deCastroVol9No1.pdf
Journal of Applied Research, v. 9, n. 1-2, p. 18-22, 2009.
1537-064X
http://hdl.handle.net/11449/71106
2-s2.0-68249141402
url http://jrnlappliedresearch.com/articles/Vol9Iss1/deCastroVol9No1.pdf
http://hdl.handle.net/11449/71106
identifier_str_mv Journal of Applied Research, v. 9, n. 1-2, p. 18-22, 2009.
1537-064X
2-s2.0-68249141402
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Applied Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18-22
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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