Evaluation of skin absorption of drugs from topical and transdermal formulations
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1984-82502016000300018 http://hdl.handle.net/11449/159250 |
Resumo: | The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of dnigs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed. |
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Repositório Institucional da UNESP |
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Evaluation of skin absorption of drugs from topical and transdermal formulationsSkin absorptioneffectsstudytopical formulationstransdermal formulationsSkin absorptionsenhancersThe skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of dnigs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Unifal-MG (Alfenas, Brazil)Univ Fed Bahia, Multidisciplinary Hlth Inst, Vitoria Da Conquista, BA, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, Araraquara, SP, BrazilUniv Fed Alfenas, Fac Pharmaceut Sci, Dept Pharm, Alfenas, MG, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, Araraquara, SP, BrazilUniv Sao Paulo, Conjunto QuimicasUniversidade Federal da Bahia (UFBA)Universidade Estadual Paulista (Unesp)Univ Fed AlfenasMorais Ruela, Andre LuisPerissinato, Aline Gravinez [UNESP]Sousa Lino, Monica Esselin deMudrik, Paula SilvaPereira, Gislaine Ribeiro2018-11-26T15:37:37Z2018-11-26T15:37:37Z2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article527-544application/pdfhttp://dx.doi.org/10.1590/S1984-82502016000300018Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 52, n. 3, p. 527-544, 2016.1984-8250http://hdl.handle.net/11449/15925010.1590/S1984-82502016000300018S1984-82502016000300527WOS:000390332400018S1984-82502016000300527.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal Of Pharmaceutical Sciences0,214info:eu-repo/semantics/openAccess2023-10-16T06:06:24Zoai:repositorio.unesp.br:11449/159250Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:05:57.010616Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of skin absorption of drugs from topical and transdermal formulations |
title |
Evaluation of skin absorption of drugs from topical and transdermal formulations |
spellingShingle |
Evaluation of skin absorption of drugs from topical and transdermal formulations Morais Ruela, Andre Luis Skin absorption effects study topical formulations transdermal formulations Skin absorptions enhancers |
title_short |
Evaluation of skin absorption of drugs from topical and transdermal formulations |
title_full |
Evaluation of skin absorption of drugs from topical and transdermal formulations |
title_fullStr |
Evaluation of skin absorption of drugs from topical and transdermal formulations |
title_full_unstemmed |
Evaluation of skin absorption of drugs from topical and transdermal formulations |
title_sort |
Evaluation of skin absorption of drugs from topical and transdermal formulations |
author |
Morais Ruela, Andre Luis |
author_facet |
Morais Ruela, Andre Luis Perissinato, Aline Gravinez [UNESP] Sousa Lino, Monica Esselin de Mudrik, Paula Silva Pereira, Gislaine Ribeiro |
author_role |
author |
author2 |
Perissinato, Aline Gravinez [UNESP] Sousa Lino, Monica Esselin de Mudrik, Paula Silva Pereira, Gislaine Ribeiro |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal da Bahia (UFBA) Universidade Estadual Paulista (Unesp) Univ Fed Alfenas |
dc.contributor.author.fl_str_mv |
Morais Ruela, Andre Luis Perissinato, Aline Gravinez [UNESP] Sousa Lino, Monica Esselin de Mudrik, Paula Silva Pereira, Gislaine Ribeiro |
dc.subject.por.fl_str_mv |
Skin absorption effects study topical formulations transdermal formulations Skin absorptions enhancers |
topic |
Skin absorption effects study topical formulations transdermal formulations Skin absorptions enhancers |
description |
The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of dnigs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-01 2018-11-26T15:37:37Z 2018-11-26T15:37:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1984-82502016000300018 Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 52, n. 3, p. 527-544, 2016. 1984-8250 http://hdl.handle.net/11449/159250 10.1590/S1984-82502016000300018 S1984-82502016000300527 WOS:000390332400018 S1984-82502016000300527.pdf |
url |
http://dx.doi.org/10.1590/S1984-82502016000300018 http://hdl.handle.net/11449/159250 |
identifier_str_mv |
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 52, n. 3, p. 527-544, 2016. 1984-8250 10.1590/S1984-82502016000300018 S1984-82502016000300527 WOS:000390332400018 S1984-82502016000300527.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal Of Pharmaceutical Sciences 0,214 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
527-544 application/pdf |
dc.publisher.none.fl_str_mv |
Univ Sao Paulo, Conjunto Quimicas |
publisher.none.fl_str_mv |
Univ Sao Paulo, Conjunto Quimicas |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128460444401664 |