Evaluation of skin absorption of drugs from topical and transdermal formulations

Detalhes bibliográficos
Autor(a) principal: Morais Ruela, Andre Luis
Data de Publicação: 2016
Outros Autores: Perissinato, Aline Gravinez [UNESP], Sousa Lino, Monica Esselin de, Mudrik, Paula Silva, Pereira, Gislaine Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1984-82502016000300018
http://hdl.handle.net/11449/159250
Resumo: The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of dnigs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed.
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spelling Evaluation of skin absorption of drugs from topical and transdermal formulationsSkin absorptioneffectsstudytopical formulationstransdermal formulationsSkin absorptionsenhancersThe skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of dnigs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Unifal-MG (Alfenas, Brazil)Univ Fed Bahia, Multidisciplinary Hlth Inst, Vitoria Da Conquista, BA, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, Araraquara, SP, BrazilUniv Fed Alfenas, Fac Pharmaceut Sci, Dept Pharm, Alfenas, MG, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, Araraquara, SP, BrazilUniv Sao Paulo, Conjunto QuimicasUniversidade Federal da Bahia (UFBA)Universidade Estadual Paulista (Unesp)Univ Fed AlfenasMorais Ruela, Andre LuisPerissinato, Aline Gravinez [UNESP]Sousa Lino, Monica Esselin deMudrik, Paula SilvaPereira, Gislaine Ribeiro2018-11-26T15:37:37Z2018-11-26T15:37:37Z2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article527-544application/pdfhttp://dx.doi.org/10.1590/S1984-82502016000300018Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 52, n. 3, p. 527-544, 2016.1984-8250http://hdl.handle.net/11449/15925010.1590/S1984-82502016000300018S1984-82502016000300527WOS:000390332400018S1984-82502016000300527.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal Of Pharmaceutical Sciences0,214info:eu-repo/semantics/openAccess2023-10-16T06:06:24Zoai:repositorio.unesp.br:11449/159250Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:05:57.010616Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of skin absorption of drugs from topical and transdermal formulations
title Evaluation of skin absorption of drugs from topical and transdermal formulations
spellingShingle Evaluation of skin absorption of drugs from topical and transdermal formulations
Morais Ruela, Andre Luis
Skin absorption
effects
study
topical formulations
transdermal formulations
Skin absorptions
enhancers
title_short Evaluation of skin absorption of drugs from topical and transdermal formulations
title_full Evaluation of skin absorption of drugs from topical and transdermal formulations
title_fullStr Evaluation of skin absorption of drugs from topical and transdermal formulations
title_full_unstemmed Evaluation of skin absorption of drugs from topical and transdermal formulations
title_sort Evaluation of skin absorption of drugs from topical and transdermal formulations
author Morais Ruela, Andre Luis
author_facet Morais Ruela, Andre Luis
Perissinato, Aline Gravinez [UNESP]
Sousa Lino, Monica Esselin de
Mudrik, Paula Silva
Pereira, Gislaine Ribeiro
author_role author
author2 Perissinato, Aline Gravinez [UNESP]
Sousa Lino, Monica Esselin de
Mudrik, Paula Silva
Pereira, Gislaine Ribeiro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal da Bahia (UFBA)
Universidade Estadual Paulista (Unesp)
Univ Fed Alfenas
dc.contributor.author.fl_str_mv Morais Ruela, Andre Luis
Perissinato, Aline Gravinez [UNESP]
Sousa Lino, Monica Esselin de
Mudrik, Paula Silva
Pereira, Gislaine Ribeiro
dc.subject.por.fl_str_mv Skin absorption
effects
study
topical formulations
transdermal formulations
Skin absorptions
enhancers
topic Skin absorption
effects
study
topical formulations
transdermal formulations
Skin absorptions
enhancers
description The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of dnigs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed.
publishDate 2016
dc.date.none.fl_str_mv 2016-07-01
2018-11-26T15:37:37Z
2018-11-26T15:37:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1984-82502016000300018
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 52, n. 3, p. 527-544, 2016.
1984-8250
http://hdl.handle.net/11449/159250
10.1590/S1984-82502016000300018
S1984-82502016000300527
WOS:000390332400018
S1984-82502016000300527.pdf
url http://dx.doi.org/10.1590/S1984-82502016000300018
http://hdl.handle.net/11449/159250
identifier_str_mv Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 52, n. 3, p. 527-544, 2016.
1984-8250
10.1590/S1984-82502016000300018
S1984-82502016000300527
WOS:000390332400018
S1984-82502016000300527.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal Of Pharmaceutical Sciences
0,214
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 527-544
application/pdf
dc.publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128460444401664