In vivo study of novel nanocomposite for prostate cancer treatment
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1088/1742-6596/617/1/012001 http://hdl.handle.net/11449/168401 |
Resumo: | Because of high occurrence of side effects of conventional anticancer drugs, new therapies have been widely studied, such as the use of non-usual molecules and the association with nanomaterials. In this context, sildenafil is a molecule that has been lately considered as a co-adjuvant in cancer therapy because it inhibits an enzyme with a potential role in tumor progression, phosphodiesterase-5. Taking into account the combination of nanoparticles and sildenafil, we produced systems based on mesoporoussilica nanoparticles, Pluronic F-127 and sildenafil as the main therapy for prostate cancer. |
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In vivo study of novel nanocomposite for prostate cancer treatmentBecause of high occurrence of side effects of conventional anticancer drugs, new therapies have been widely studied, such as the use of non-usual molecules and the association with nanomaterials. In this context, sildenafil is a molecule that has been lately considered as a co-adjuvant in cancer therapy because it inhibits an enzyme with a potential role in tumor progression, phosphodiesterase-5. Taking into account the combination of nanoparticles and sildenafil, we produced systems based on mesoporoussilica nanoparticles, Pluronic F-127 and sildenafil as the main therapy for prostate cancer.Chemistry Institute Universidade Estadual de Campinas (UNICAMP) Campus Universitário Zeferino Vaz, s/n, Cidade UniversitáriaDepartment of Physics Universidade Federal Do Ceará (UFC), Avenida da Universidade, Benfica, CEP 60020-181, CEDepartment of Environmental Engineering Universidade Estadual Paulista (UNESP), Avenida Trěs de Março, CEP 18087-180, SPFarmabrasilis R and D DivisionNanobioss Chemistry Institute Universidade Estadual de Campinas (UNICAMP) Campus Universitário Zeferino Vaz, s/n, Cidade UniversitáriaDepartment of Environmental Engineering Universidade Estadual Paulista (UNESP), Avenida Trěs de Março, CEP 18087-180, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Federal Do Ceará (UFC)Universidade Estadual Paulista (Unesp)Farmabrasilis R and D DivisionSilveira, C. P.Paula, A. J.Apolinário, L. M. [UNESP]Fávaro, W. J. [UNESP]Durán, N.2018-12-11T16:41:07Z2018-12-11T16:41:07Z2015-05-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectapplication/pdfhttp://dx.doi.org/10.1088/1742-6596/617/1/012001Journal of Physics: Conference Series, v. 617, n. 1, 2015.1742-65961742-6588http://hdl.handle.net/11449/16840110.1088/1742-6596/617/1/0120012-s2.0-849586175742-s2.0-84958617574.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Physics: Conference Series0,2410,241info:eu-repo/semantics/openAccess2023-11-22T06:17:32Zoai:repositorio.unesp.br:11449/168401Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:26:50.989308Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vivo study of novel nanocomposite for prostate cancer treatment |
title |
In vivo study of novel nanocomposite for prostate cancer treatment |
spellingShingle |
In vivo study of novel nanocomposite for prostate cancer treatment Silveira, C. P. |
title_short |
In vivo study of novel nanocomposite for prostate cancer treatment |
title_full |
In vivo study of novel nanocomposite for prostate cancer treatment |
title_fullStr |
In vivo study of novel nanocomposite for prostate cancer treatment |
title_full_unstemmed |
In vivo study of novel nanocomposite for prostate cancer treatment |
title_sort |
In vivo study of novel nanocomposite for prostate cancer treatment |
author |
Silveira, C. P. |
author_facet |
Silveira, C. P. Paula, A. J. Apolinário, L. M. [UNESP] Fávaro, W. J. [UNESP] Durán, N. |
author_role |
author |
author2 |
Paula, A. J. Apolinário, L. M. [UNESP] Fávaro, W. J. [UNESP] Durán, N. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Federal Do Ceará (UFC) Universidade Estadual Paulista (Unesp) Farmabrasilis R and D Division |
dc.contributor.author.fl_str_mv |
Silveira, C. P. Paula, A. J. Apolinário, L. M. [UNESP] Fávaro, W. J. [UNESP] Durán, N. |
description |
Because of high occurrence of side effects of conventional anticancer drugs, new therapies have been widely studied, such as the use of non-usual molecules and the association with nanomaterials. In this context, sildenafil is a molecule that has been lately considered as a co-adjuvant in cancer therapy because it inhibits an enzyme with a potential role in tumor progression, phosphodiesterase-5. Taking into account the combination of nanoparticles and sildenafil, we produced systems based on mesoporoussilica nanoparticles, Pluronic F-127 and sildenafil as the main therapy for prostate cancer. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-05-26 2018-12-11T16:41:07Z 2018-12-11T16:41:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1088/1742-6596/617/1/012001 Journal of Physics: Conference Series, v. 617, n. 1, 2015. 1742-6596 1742-6588 http://hdl.handle.net/11449/168401 10.1088/1742-6596/617/1/012001 2-s2.0-84958617574 2-s2.0-84958617574.pdf |
url |
http://dx.doi.org/10.1088/1742-6596/617/1/012001 http://hdl.handle.net/11449/168401 |
identifier_str_mv |
Journal of Physics: Conference Series, v. 617, n. 1, 2015. 1742-6596 1742-6588 10.1088/1742-6596/617/1/012001 2-s2.0-84958617574 2-s2.0-84958617574.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Physics: Conference Series 0,241 0,241 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128933771608064 |