Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.clinph.2015.05.003 http://hdl.handle.net/11449/165022 |
Resumo: | Objectives: The response time (RT) to kinesthetic perception has been used as a proprioceptive measurement, for example, in older individuals. However, the RT cannot provide information on impairments at specific stages of the respective sensorimotor processing. In the present study, electroencephalographic (EEG) signals were recorded during passive ankle movement with and without an associated perceptual task of movement detection. The main purpose was to analyze differences between young and older adults both in terms of RT and cortical responses. Putative differences in the latter were expected to point to changes in the processing associated with neural pathways or cortical regions in the older subjects. Methods: The EEG activity of nineteen older (OA, 65-76 years) and 19 young adults (YA, 21-32 years) was recorded during passive ankle movement, without motor voluntary response (NVR, sensory condition), and during a condition with voluntary motor response (VR, with measurement of the RT). Event-related potentials (ERP) and beta event-related desynchronization/synchronization (ERD/ERS) were recorded and analyzed in both experimental conditions. Results: The RT in OA was larger than in YA (P < 0.0001). EEG analyses showed that the N1 amplitude was larger in the VR than in the NVR condition (P = 0.006), whereas no difference for latency was obtained between conditions (P = 0.376). Comparisons between the groups revealed attenuated (P = 0.019) and delayed (P = 0.001) N1 in the OA group, irrespective of the condition (no interaction group vs condition). Only OA showed correlations between RT and N1, with significant correlation for both amplitude (r = -0.603, P = 0.006) and latency (r = 0.703, P = 0.001). The ERD/ERS analyses revealed a task-dependent group effect: in NVR, significant differences were obtained only for the ERS amplitude, which was attenuated in OA (P = 0.003). In VR, larger (P = 0.004) and delayed (P = 0.003) ERD and attenuated (P = 0.029) and delayed (P = 0.017) ERS peaks were observed in the older group. Conclusions: The results suggest that a larger response time to proprioceptive stimuli in older adults is associated with a weaker and delayed proprioceptive afferent inflow to the cortex. In this scenario, older adults would need a higher cognitive effort (larger ERD) to process the sensory inputs when attempting to properly perform a sensorimotor task. Significance: ERP and ERD/ERS measurements during kinesthetic assessment provide new insights on identification of the origin of sensorimotor slowing in older adults. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
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Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movementAgingProprioceptionPassive movementEvent-related potentialBeta ERD/ERSObjectives: The response time (RT) to kinesthetic perception has been used as a proprioceptive measurement, for example, in older individuals. However, the RT cannot provide information on impairments at specific stages of the respective sensorimotor processing. In the present study, electroencephalographic (EEG) signals were recorded during passive ankle movement with and without an associated perceptual task of movement detection. The main purpose was to analyze differences between young and older adults both in terms of RT and cortical responses. Putative differences in the latter were expected to point to changes in the processing associated with neural pathways or cortical regions in the older subjects. Methods: The EEG activity of nineteen older (OA, 65-76 years) and 19 young adults (YA, 21-32 years) was recorded during passive ankle movement, without motor voluntary response (NVR, sensory condition), and during a condition with voluntary motor response (VR, with measurement of the RT). Event-related potentials (ERP) and beta event-related desynchronization/synchronization (ERD/ERS) were recorded and analyzed in both experimental conditions. Results: The RT in OA was larger than in YA (P < 0.0001). EEG analyses showed that the N1 amplitude was larger in the VR than in the NVR condition (P = 0.006), whereas no difference for latency was obtained between conditions (P = 0.376). Comparisons between the groups revealed attenuated (P = 0.019) and delayed (P = 0.001) N1 in the OA group, irrespective of the condition (no interaction group vs condition). Only OA showed correlations between RT and N1, with significant correlation for both amplitude (r = -0.603, P = 0.006) and latency (r = 0.703, P = 0.001). The ERD/ERS analyses revealed a task-dependent group effect: in NVR, significant differences were obtained only for the ERS amplitude, which was attenuated in OA (P = 0.003). In VR, larger (P = 0.004) and delayed (P = 0.003) ERD and attenuated (P = 0.029) and delayed (P = 0.017) ERS peaks were observed in the older group. Conclusions: The results suggest that a larger response time to proprioceptive stimuli in older adults is associated with a weaker and delayed proprioceptive afferent inflow to the cortex. In this scenario, older adults would need a higher cognitive effort (larger ERD) to process the sensory inputs when attempting to properly perform a sensorimotor task. Significance: ERP and ERD/ERS measurements during kinesthetic assessment provide new insights on identification of the origin of sensorimotor slowing in older adults. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Neurosci Program, EP USP, PTC, BR-05508900 Sao Paulo, SP, BrazilUniv Sao Paulo, Biomed Engn Lab, EP USP, PTC, Ave Prof Luciano Gualberto,Travessa 3,158, BR-05508900 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Div Neurol, Sao Paulo, BrazilUniv Cruzeiro Sul, Inst Phys Act & Sport Sci, Sao Paulo, BrazilUniv Cruzeiro Sul, Grad Program Human Movement Sci, Sao Paulo, BrazilSao Paulo State Univ, Inst Biosci, Rio Claro, BrazilSao Paulo State Univ, Inst Biosci, Rio Claro, BrazilFAPESP: 2011/17193-0FAPESP: 2013/14667-7CNPq: 303313/2011-0: 2009/09286-9Elsevier B.V.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Univ Cruzeiro SulUniversidade Estadual Paulista (Unesp)Toledo, Diana R.Manzano, Gilberto M.Barela, Jose A. [UNESP]Kohn, Andre F.2018-11-27T06:00:17Z2018-11-27T06:00:17Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article655-663application/pdfhttp://dx.doi.org/10.1016/j.clinph.2015.05.003Clinical Neurophysiology. Clare: Elsevier Ireland Ltd, v. 127, n. 1, p. 655-663, 2016.1388-2457http://hdl.handle.net/11449/16502210.1016/j.clinph.2015.05.003WOS:000367540800078WOS000367540800078.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Neurophysiology1,561info:eu-repo/semantics/openAccess2023-10-10T06:02:25Zoai:repositorio.unesp.br:11449/165022Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-10T06:02:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement |
title |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement |
spellingShingle |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement Toledo, Diana R. Aging Proprioception Passive movement Event-related potential Beta ERD/ERS |
title_short |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement |
title_full |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement |
title_fullStr |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement |
title_full_unstemmed |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement |
title_sort |
Cortical correlates of response time slowing in older adults: ERP and ERD/ERS analyses during passive ankle movement |
author |
Toledo, Diana R. |
author_facet |
Toledo, Diana R. Manzano, Gilberto M. Barela, Jose A. [UNESP] Kohn, Andre F. |
author_role |
author |
author2 |
Manzano, Gilberto M. Barela, Jose A. [UNESP] Kohn, Andre F. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Univ Cruzeiro Sul Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Toledo, Diana R. Manzano, Gilberto M. Barela, Jose A. [UNESP] Kohn, Andre F. |
dc.subject.por.fl_str_mv |
Aging Proprioception Passive movement Event-related potential Beta ERD/ERS |
topic |
Aging Proprioception Passive movement Event-related potential Beta ERD/ERS |
description |
Objectives: The response time (RT) to kinesthetic perception has been used as a proprioceptive measurement, for example, in older individuals. However, the RT cannot provide information on impairments at specific stages of the respective sensorimotor processing. In the present study, electroencephalographic (EEG) signals were recorded during passive ankle movement with and without an associated perceptual task of movement detection. The main purpose was to analyze differences between young and older adults both in terms of RT and cortical responses. Putative differences in the latter were expected to point to changes in the processing associated with neural pathways or cortical regions in the older subjects. Methods: The EEG activity of nineteen older (OA, 65-76 years) and 19 young adults (YA, 21-32 years) was recorded during passive ankle movement, without motor voluntary response (NVR, sensory condition), and during a condition with voluntary motor response (VR, with measurement of the RT). Event-related potentials (ERP) and beta event-related desynchronization/synchronization (ERD/ERS) were recorded and analyzed in both experimental conditions. Results: The RT in OA was larger than in YA (P < 0.0001). EEG analyses showed that the N1 amplitude was larger in the VR than in the NVR condition (P = 0.006), whereas no difference for latency was obtained between conditions (P = 0.376). Comparisons between the groups revealed attenuated (P = 0.019) and delayed (P = 0.001) N1 in the OA group, irrespective of the condition (no interaction group vs condition). Only OA showed correlations between RT and N1, with significant correlation for both amplitude (r = -0.603, P = 0.006) and latency (r = 0.703, P = 0.001). The ERD/ERS analyses revealed a task-dependent group effect: in NVR, significant differences were obtained only for the ERS amplitude, which was attenuated in OA (P = 0.003). In VR, larger (P = 0.004) and delayed (P = 0.003) ERD and attenuated (P = 0.029) and delayed (P = 0.017) ERS peaks were observed in the older group. Conclusions: The results suggest that a larger response time to proprioceptive stimuli in older adults is associated with a weaker and delayed proprioceptive afferent inflow to the cortex. In this scenario, older adults would need a higher cognitive effort (larger ERD) to process the sensory inputs when attempting to properly perform a sensorimotor task. Significance: ERP and ERD/ERS measurements during kinesthetic assessment provide new insights on identification of the origin of sensorimotor slowing in older adults. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-11-27T06:00:17Z 2018-11-27T06:00:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.clinph.2015.05.003 Clinical Neurophysiology. Clare: Elsevier Ireland Ltd, v. 127, n. 1, p. 655-663, 2016. 1388-2457 http://hdl.handle.net/11449/165022 10.1016/j.clinph.2015.05.003 WOS:000367540800078 WOS000367540800078.pdf |
url |
http://dx.doi.org/10.1016/j.clinph.2015.05.003 http://hdl.handle.net/11449/165022 |
identifier_str_mv |
Clinical Neurophysiology. Clare: Elsevier Ireland Ltd, v. 127, n. 1, p. 655-663, 2016. 1388-2457 10.1016/j.clinph.2015.05.003 WOS:000367540800078 WOS000367540800078.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Neurophysiology 1,561 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
655-663 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803649368164663296 |