Aspectos fundamentais no desenvolvimento de sistemas microemulsionados contendo anfotericina B para uso oftálmico

• Autor(a) principal: Lima Silveira, Walteçá Louis
• Data de Publicação: 2013
• Outros Autores: de Lima Damasceno, Bolivar Ponciano Goulart, Silva, Kattya Gyselle Holanda [UNESP], Oliveira, Anselmo Gomes de [UNESP], Egito, Eryvaldo Sócrates Tabosa
• Tipo de documento: Artigo
• Idioma: eng; por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/2300; http://hdl.handle.net/11449/75038
• topic: Amphotericin B; Eye; Microemulsions; Ophthalmic solutions; amphotericin B; cornea epithelium; drug absorption; drug bioavailability; drug vehicle; fungal eye infection; human; microemulsion; ophthalmology; physical chemistry; thermodynamics

As occurs with a number of drugs, the bioavailability of amphotericin B (AmB) used to treat fungal infections by the ocular route remains a great challenge to research scientists. In fact, the poor bioavailability of AmB is due mainly to the corneal barrier, which leads to a precorneal loss and consequent decrease in the absorption of this drug into the intraocular tissues. The toxicity associated with this molecule, together with its poor ability to penetrate the intact corneal epithelium, also represents a major drawback to its clinical use. New effective and safe drug vehicles for ocular delivery of AmB are therefore urgently needed. Microemulsions (MEs) seem to be an interesting system, owing to their transparent appearance, thermodynamic stability and favorable viscosity. Knowledge of the process of formation of AmB-containing MEs, as well as a good understanding of the physical chemistry of such systems, would provide reliable information on the best conditions for the use of these systems as eye drops. The goal of this research was thus to make an approach to this subject by reviewing the main studies on the use of MEs as delivery systems for AmB in topical eye treatment.