Absence of mutagenicity of plants used to treat gastrointestinal disorders
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2298/ABS1301191S http://hdl.handle.net/11449/74564 |
Resumo: | The Brazilian Savanna (locally called Cerrado) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with compounds obtained from different species have shown the risks of DNA damage. The present work assessed the in vivo mutagenicity of three plant species used in popular medicine to treat human gastrointestinal disorders (Mouriri pusa, Qualea grandiflora and Qualea multiflora). The micronucleus assay was performed in peripheral blood of mice submitted to acute treatments. Results showed that no assessed extracts were mutagenic in vivo. In fact, the absence of mutagenicity in the present study indicates that the extracts do not contain compounds capable of inducing DNA breaks or chromosomal loss. However, further analysis should be performed in others systems to guarantee their safety, mainly to human chronic use. |
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Repositório Institucional da UNESP |
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Absence of mutagenicity of plants used to treat gastrointestinal disordersBrazilian savannaDNA damageMedicinal plantsMicronucleus assayMutagenicityThe Brazilian Savanna (locally called Cerrado) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with compounds obtained from different species have shown the risks of DNA damage. The present work assessed the in vivo mutagenicity of three plant species used in popular medicine to treat human gastrointestinal disorders (Mouriri pusa, Qualea grandiflora and Qualea multiflora). The micronucleus assay was performed in peripheral blood of mice submitted to acute treatments. Results showed that no assessed extracts were mutagenic in vivo. In fact, the absence of mutagenicity in the present study indicates that the extracts do not contain compounds capable of inducing DNA breaks or chromosomal loss. However, further analysis should be performed in others systems to guarantee their safety, mainly to human chronic use.Universidade Federal de São João Del Rei (UFSJ) Campus Centro-Oeste, Divinópolis, MGUniversidade Estadual Paulista (UNESP) Instituto de Química, Araraquara, SPUniversidade Federal de São João Del Rei (UFSJ) Campus Dom Bosco Departamento de Engenharia de Biossistemas, São João Del Rei, MGUniversidade Estadual de Londrina (UEL) Departamento de Biologia Geral, Londrina, PRUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Araraquara, SPUniversidade Estadual Paulista (UNESP) Instituto de Química, Araraquara, SPUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Araraquara, SPUniversidade Federal de Sergipe (UFS)Universidade Estadual Paulista (Unesp)Universidade Estadual de Londrina (UEL)Santos, F. V.Andreo, M. [UNESP]Nasser, A. L M [UNESP]Moreira, L. M.Vilegas, Wagner [UNESP]Cólus, I. M SVaranda, Eliana Aparecida [UNESP]2014-05-27T11:28:21Z2014-05-27T11:28:21Z2013-02-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article191-195application/pdfhttp://dx.doi.org/10.2298/ABS1301191SArchives of Biological Sciences, v. 65, n. 1, p. 191-195, 2013.0354-4664http://hdl.handle.net/11449/7456410.2298/ABS1301191SWOS:0003120463000232-s2.0-848731895372-s2.0-84873189537.pdf79278772243268370000-0003-3032-2556Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Biological Sciences0.6480,232info:eu-repo/semantics/openAccess2023-11-04T06:06:52Zoai:repositorio.unesp.br:11449/74564Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-04T06:06:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Absence of mutagenicity of plants used to treat gastrointestinal disorders |
title |
Absence of mutagenicity of plants used to treat gastrointestinal disorders |
spellingShingle |
Absence of mutagenicity of plants used to treat gastrointestinal disorders Santos, F. V. Brazilian savanna DNA damage Medicinal plants Micronucleus assay Mutagenicity |
title_short |
Absence of mutagenicity of plants used to treat gastrointestinal disorders |
title_full |
Absence of mutagenicity of plants used to treat gastrointestinal disorders |
title_fullStr |
Absence of mutagenicity of plants used to treat gastrointestinal disorders |
title_full_unstemmed |
Absence of mutagenicity of plants used to treat gastrointestinal disorders |
title_sort |
Absence of mutagenicity of plants used to treat gastrointestinal disorders |
author |
Santos, F. V. |
author_facet |
Santos, F. V. Andreo, M. [UNESP] Nasser, A. L M [UNESP] Moreira, L. M. Vilegas, Wagner [UNESP] Cólus, I. M S Varanda, Eliana Aparecida [UNESP] |
author_role |
author |
author2 |
Andreo, M. [UNESP] Nasser, A. L M [UNESP] Moreira, L. M. Vilegas, Wagner [UNESP] Cólus, I. M S Varanda, Eliana Aparecida [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Sergipe (UFS) Universidade Estadual Paulista (Unesp) Universidade Estadual de Londrina (UEL) |
dc.contributor.author.fl_str_mv |
Santos, F. V. Andreo, M. [UNESP] Nasser, A. L M [UNESP] Moreira, L. M. Vilegas, Wagner [UNESP] Cólus, I. M S Varanda, Eliana Aparecida [UNESP] |
dc.subject.por.fl_str_mv |
Brazilian savanna DNA damage Medicinal plants Micronucleus assay Mutagenicity |
topic |
Brazilian savanna DNA damage Medicinal plants Micronucleus assay Mutagenicity |
description |
The Brazilian Savanna (locally called Cerrado) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with compounds obtained from different species have shown the risks of DNA damage. The present work assessed the in vivo mutagenicity of three plant species used in popular medicine to treat human gastrointestinal disorders (Mouriri pusa, Qualea grandiflora and Qualea multiflora). The micronucleus assay was performed in peripheral blood of mice submitted to acute treatments. Results showed that no assessed extracts were mutagenic in vivo. In fact, the absence of mutagenicity in the present study indicates that the extracts do not contain compounds capable of inducing DNA breaks or chromosomal loss. However, further analysis should be performed in others systems to guarantee their safety, mainly to human chronic use. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02-06 2014-05-27T11:28:21Z 2014-05-27T11:28:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2298/ABS1301191S Archives of Biological Sciences, v. 65, n. 1, p. 191-195, 2013. 0354-4664 http://hdl.handle.net/11449/74564 10.2298/ABS1301191S WOS:000312046300023 2-s2.0-84873189537 2-s2.0-84873189537.pdf 7927877224326837 0000-0003-3032-2556 |
url |
http://dx.doi.org/10.2298/ABS1301191S http://hdl.handle.net/11449/74564 |
identifier_str_mv |
Archives of Biological Sciences, v. 65, n. 1, p. 191-195, 2013. 0354-4664 10.2298/ABS1301191S WOS:000312046300023 2-s2.0-84873189537 2-s2.0-84873189537.pdf 7927877224326837 0000-0003-3032-2556 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Biological Sciences 0.648 0,232 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
191-195 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964810978263040 |