Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases

Detalhes bibliográficos
Autor(a) principal: Laskoski, Luciane Maria
Data de Publicação: 2016
Outros Autores: Dittrich, Rosangela Locatelli, Valadão, Carlos Augusto Araújo [UNESP], Brum, Juliana Sperotto, Brandão, Yara, Brito, Harald Fernando Vicente, de Sousa, Renato Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.vetimm.2016.02.008
http://hdl.handle.net/11449/177834
Resumo: Tissue damage caused by oxidative stress is involved in the pathogenesis of several diseases in animals and man, and is believed to play a role in the development of laminitis in horses. The aim of this study was to investigate the oxidative stress associated with laminar lesions in horses with lethal gastrointestinal disorders. Laminar tissue samples of the hoof of 30 horses were used. Tissue samples were divided as follows: six healthy horses (control group-CG), and 24 horses that died after complications of gastrointestinal diseases (group suffering from gastrointestinal disorders-GDG). Superoxide dismutase (SOD2) and nitrotyrosine immunostaining and the severity of laminar lesions were evaluated. Presence of laminar lesions and immunostaining for nitrotyrosine and SOD2 were only evident in horses from the GDG group. Thus, oxidative stress may play a role in the pathogenesis of laminar lesions secondary to gastrointestinal disorders.
id UNSP_3791b2e2ac668a54e3dfaa98b2ece6c8
oai_identifier_str oai:repositorio.unesp.br:11449/177834
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseasesEquineImmunohistochemistryLaminitisNitrotyrosineSuperoxide dismutaseTissue damage caused by oxidative stress is involved in the pathogenesis of several diseases in animals and man, and is believed to play a role in the development of laminitis in horses. The aim of this study was to investigate the oxidative stress associated with laminar lesions in horses with lethal gastrointestinal disorders. Laminar tissue samples of the hoof of 30 horses were used. Tissue samples were divided as follows: six healthy horses (control group-CG), and 24 horses that died after complications of gastrointestinal diseases (group suffering from gastrointestinal disorders-GDG). Superoxide dismutase (SOD2) and nitrotyrosine immunostaining and the severity of laminar lesions were evaluated. Presence of laminar lesions and immunostaining for nitrotyrosine and SOD2 were only evident in horses from the GDG group. Thus, oxidative stress may play a role in the pathogenesis of laminar lesions secondary to gastrointestinal disorders.Graduate School in Veterinary Sciences Federal University of Paraná (Curitiba campus), Rua dos Funcionários, 1540Graduate School in Veterinary Surgery São Paulo State Univ. Júlio de Mesquita Filho - UNESP (Jaboticabal campus), Via de Acesso Professor Paulo Donato Castellane, s/nGraduate School in Microbiology Parasitology and Patology Federal University of Paraná (Curitiba campus), Avenida Coronel Francisco H. dos Santos, s/nDepartment of Veterinary Medicine Federal University of Paraná (Curitiba campus), Rua dos Funcionários, 1540Graduate School in Veterinary Surgery São Paulo State Univ. Júlio de Mesquita Filho - UNESP (Jaboticabal campus), Via de Acesso Professor Paulo Donato Castellane, s/nFederal University of Paraná (Curitiba campus)Universidade Estadual Paulista (Unesp)Laskoski, Luciane MariaDittrich, Rosangela LocatelliValadão, Carlos Augusto Araújo [UNESP]Brum, Juliana SperottoBrandão, YaraBrito, Harald Fernando Vicentede Sousa, Renato Silva2018-12-11T17:27:21Z2018-12-11T17:27:21Z2016-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article66-72application/pdfhttp://dx.doi.org/10.1016/j.vetimm.2016.02.008Veterinary Immunology and Immunopathology, v. 171, p. 66-72.1873-25340165-2427http://hdl.handle.net/11449/17783410.1016/j.vetimm.2016.02.0082-s2.0-849590190362-s2.0-84959019036.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Immunology and Immunopathology0,680info:eu-repo/semantics/openAccess2024-06-06T14:10:35Zoai:repositorio.unesp.br:11449/177834Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:48:58.201710Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
title Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
spellingShingle Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
Laskoski, Luciane Maria
Equine
Immunohistochemistry
Laminitis
Nitrotyrosine
Superoxide dismutase
title_short Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
title_full Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
title_fullStr Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
title_full_unstemmed Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
title_sort Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases
author Laskoski, Luciane Maria
author_facet Laskoski, Luciane Maria
Dittrich, Rosangela Locatelli
Valadão, Carlos Augusto Araújo [UNESP]
Brum, Juliana Sperotto
Brandão, Yara
Brito, Harald Fernando Vicente
de Sousa, Renato Silva
author_role author
author2 Dittrich, Rosangela Locatelli
Valadão, Carlos Augusto Araújo [UNESP]
Brum, Juliana Sperotto
Brandão, Yara
Brito, Harald Fernando Vicente
de Sousa, Renato Silva
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Federal University of Paraná (Curitiba campus)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Laskoski, Luciane Maria
Dittrich, Rosangela Locatelli
Valadão, Carlos Augusto Araújo [UNESP]
Brum, Juliana Sperotto
Brandão, Yara
Brito, Harald Fernando Vicente
de Sousa, Renato Silva
dc.subject.por.fl_str_mv Equine
Immunohistochemistry
Laminitis
Nitrotyrosine
Superoxide dismutase
topic Equine
Immunohistochemistry
Laminitis
Nitrotyrosine
Superoxide dismutase
description Tissue damage caused by oxidative stress is involved in the pathogenesis of several diseases in animals and man, and is believed to play a role in the development of laminitis in horses. The aim of this study was to investigate the oxidative stress associated with laminar lesions in horses with lethal gastrointestinal disorders. Laminar tissue samples of the hoof of 30 horses were used. Tissue samples were divided as follows: six healthy horses (control group-CG), and 24 horses that died after complications of gastrointestinal diseases (group suffering from gastrointestinal disorders-GDG). Superoxide dismutase (SOD2) and nitrotyrosine immunostaining and the severity of laminar lesions were evaluated. Presence of laminar lesions and immunostaining for nitrotyrosine and SOD2 were only evident in horses from the GDG group. Thus, oxidative stress may play a role in the pathogenesis of laminar lesions secondary to gastrointestinal disorders.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-01
2018-12-11T17:27:21Z
2018-12-11T17:27:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.vetimm.2016.02.008
Veterinary Immunology and Immunopathology, v. 171, p. 66-72.
1873-2534
0165-2427
http://hdl.handle.net/11449/177834
10.1016/j.vetimm.2016.02.008
2-s2.0-84959019036
2-s2.0-84959019036.pdf
url http://dx.doi.org/10.1016/j.vetimm.2016.02.008
http://hdl.handle.net/11449/177834
identifier_str_mv Veterinary Immunology and Immunopathology, v. 171, p. 66-72.
1873-2534
0165-2427
10.1016/j.vetimm.2016.02.008
2-s2.0-84959019036
2-s2.0-84959019036.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Veterinary Immunology and Immunopathology
0,680
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 66-72
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129251902226432

Registros relacionados