Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications

Detalhes bibliográficos
Autor(a) principal: Teixeira, Jean Valdir Uchôa [UNESP]
Data de Publicação: 2021
Outros Autores: Maia, Fátima Raquel Azevedo, Carvalho, Mariana, Reis, Rui, Oliveira, Joaquim Miguel, Lisboa-Filho, Paulo Noronha [UNESP], Claro, Ana Paula Rosifni Alves [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2217/nnm-2020-0312
http://hdl.handle.net/11449/207152
Resumo: Aim: To established a simple, controlled and reproducible method to synthesize gallium (Ga)-coated polydopamine (PDA) nanoparticles (NPs). Materials & methods: PDA NPs were synthesized in alkali medium with posterior Ga shell formation due to ion chelation on the NP surface. Results: The obtained results with energy-dispersive X-ray spectroscopy confirmed the incorporation of Ga on the PDA NP surface. The cytotoxicity of Ga-coated PDA NPs was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells. Further cell analysis also demonstrated the benefit of Ga-coated PDA NPs, which increased the cell proliferation rate compared with noncoated PDA NPs. Conclusion: This study indicated that Ga could work as an appropriate shell for PDA NPs, inducing cell proliferation at the analyzed concentrations.
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spelling Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applicationscore/shellcytotoxicitygallium incorporationnanoparticle synthesisAim: To established a simple, controlled and reproducible method to synthesize gallium (Ga)-coated polydopamine (PDA) nanoparticles (NPs). Materials & methods: PDA NPs were synthesized in alkali medium with posterior Ga shell formation due to ion chelation on the NP surface. Results: The obtained results with energy-dispersive X-ray spectroscopy confirmed the incorporation of Ga on the PDA NP surface. The cytotoxicity of Ga-coated PDA NPs was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells. Further cell analysis also demonstrated the benefit of Ga-coated PDA NPs, which increased the cell proliferation rate compared with noncoated PDA NPs. Conclusion: This study indicated that Ga could work as an appropriate shell for PDA NPs, inducing cell proliferation at the analyzed concentrations.Department of Materials and Technology School of Engineering UNESP-São Paulo State University Guaratinguetá CampusB'S Research Group I3Bs-Research Institute on Biomaterials Biodegradables and Biomimetics University of MinhoICVS/3B's-PT Government Associate LaboratorySchool of Sciences UNESP-São Paulo State UniversityDepartment of Materials and Technology School of Engineering UNESP-São Paulo State University Guaratinguetá CampusSchool of Sciences UNESP-São Paulo State UniversityUniversidade Estadual Paulista (Unesp)University of MinhoICVS/3B's-PT Government Associate LaboratoryTeixeira, Jean Valdir Uchôa [UNESP]Maia, Fátima Raquel AzevedoCarvalho, MarianaReis, RuiOliveira, Joaquim MiguelLisboa-Filho, Paulo Noronha [UNESP]Claro, Ana Paula Rosifni Alves [UNESP]2021-06-25T10:49:46Z2021-06-25T10:49:46Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5-17http://dx.doi.org/10.2217/nnm-2020-0312Nanomedicine, v. 16, n. 1, p. 5-17, 2021.1748-69631743-5889http://hdl.handle.net/11449/20715210.2217/nnm-2020-03122-s2.0-85099547905Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanomedicineinfo:eu-repo/semantics/openAccess2024-07-02T15:03:37Zoai:repositorio.unesp.br:11449/207152Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:24:10.300538Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
title Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
spellingShingle Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
Teixeira, Jean Valdir Uchôa [UNESP]
core/shell
cytotoxicity
gallium incorporation
nanoparticle synthesis
title_short Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
title_full Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
title_fullStr Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
title_full_unstemmed Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
title_sort Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications
author Teixeira, Jean Valdir Uchôa [UNESP]
author_facet Teixeira, Jean Valdir Uchôa [UNESP]
Maia, Fátima Raquel Azevedo
Carvalho, Mariana
Reis, Rui
Oliveira, Joaquim Miguel
Lisboa-Filho, Paulo Noronha [UNESP]
Claro, Ana Paula Rosifni Alves [UNESP]
author_role author
author2 Maia, Fátima Raquel Azevedo
Carvalho, Mariana
Reis, Rui
Oliveira, Joaquim Miguel
Lisboa-Filho, Paulo Noronha [UNESP]
Claro, Ana Paula Rosifni Alves [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University of Minho
ICVS/3B's-PT Government Associate Laboratory
dc.contributor.author.fl_str_mv Teixeira, Jean Valdir Uchôa [UNESP]
Maia, Fátima Raquel Azevedo
Carvalho, Mariana
Reis, Rui
Oliveira, Joaquim Miguel
Lisboa-Filho, Paulo Noronha [UNESP]
Claro, Ana Paula Rosifni Alves [UNESP]
dc.subject.por.fl_str_mv core/shell
cytotoxicity
gallium incorporation
nanoparticle synthesis
topic core/shell
cytotoxicity
gallium incorporation
nanoparticle synthesis
description Aim: To established a simple, controlled and reproducible method to synthesize gallium (Ga)-coated polydopamine (PDA) nanoparticles (NPs). Materials & methods: PDA NPs were synthesized in alkali medium with posterior Ga shell formation due to ion chelation on the NP surface. Results: The obtained results with energy-dispersive X-ray spectroscopy confirmed the incorporation of Ga on the PDA NP surface. The cytotoxicity of Ga-coated PDA NPs was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells. Further cell analysis also demonstrated the benefit of Ga-coated PDA NPs, which increased the cell proliferation rate compared with noncoated PDA NPs. Conclusion: This study indicated that Ga could work as an appropriate shell for PDA NPs, inducing cell proliferation at the analyzed concentrations.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:49:46Z
2021-06-25T10:49:46Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2217/nnm-2020-0312
Nanomedicine, v. 16, n. 1, p. 5-17, 2021.
1748-6963
1743-5889
http://hdl.handle.net/11449/207152
10.2217/nnm-2020-0312
2-s2.0-85099547905
url http://dx.doi.org/10.2217/nnm-2020-0312
http://hdl.handle.net/11449/207152
identifier_str_mv Nanomedicine, v. 16, n. 1, p. 5-17, 2021.
1748-6963
1743-5889
10.2217/nnm-2020-0312
2-s2.0-85099547905
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nanomedicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5-17
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128509570187264

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