Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2174/1574886316666211014155946 http://hdl.handle.net/11449/241375 |
Resumo: | Background: Extemporaneous compounding (EC) involves the preparation of a therapeutic product for specific patient need. However, there is a potential relationship between this procedure and the occurrence of health incidents (HI). The use of trigger tools increases HI identification. Objective: This study assessed the performance of EC as a trigger to detect potential health incidents arising from this procedure. Methods: A one-month observational and cross-sectional study was performed in internal medicine ward and intensive care unit of medium-sized hospital. Data collection was carried out in 5 stages: all triggered patients with dysphagia or enteral feeding tube with prescription of EC were included; EC executed in prescribed standardized drugs was observed; the procedure was compared with the hospital guide and scientific literature; HI monitoring and their evaluation using WHO and NCC MERP algorithms; a search for pharmaceutical alternatives (PA) that would avoid the observed EC. Results: 197 patients were recruited. Almost half of them were triggered by EC from 84 standardized drugs. 48 patients met the inclusion criteria. 28 adverse drug reactions, 01 therapeutic ineffectiveness, and 29 medication errors were identified. EC as a trigger tool showed a PPV value of 0.38. Only 24 drugs have PA available in the market, which could avoid one third of all observed EC. Conclusion: It was possible to detect potentially HI in one of two patients with enteral feeding tubes using EC as a trigger tool. The use of EC as a trigger tool contributes to identifying potential HI arising from drugs, which have not gotten pharmaceutical alternatives to be administered via enteral feeding tube. |
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Repositório Institucional da UNESP |
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Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidentsadverse drug eventextemporaneous compoundingmedication therapy managementPatient safetypharmacy servicetrigger toolBackground: Extemporaneous compounding (EC) involves the preparation of a therapeutic product for specific patient need. However, there is a potential relationship between this procedure and the occurrence of health incidents (HI). The use of trigger tools increases HI identification. Objective: This study assessed the performance of EC as a trigger to detect potential health incidents arising from this procedure. Methods: A one-month observational and cross-sectional study was performed in internal medicine ward and intensive care unit of medium-sized hospital. Data collection was carried out in 5 stages: all triggered patients with dysphagia or enteral feeding tube with prescription of EC were included; EC executed in prescribed standardized drugs was observed; the procedure was compared with the hospital guide and scientific literature; HI monitoring and their evaluation using WHO and NCC MERP algorithms; a search for pharmaceutical alternatives (PA) that would avoid the observed EC. Results: 197 patients were recruited. Almost half of them were triggered by EC from 84 standardized drugs. 48 patients met the inclusion criteria. 28 adverse drug reactions, 01 therapeutic ineffectiveness, and 29 medication errors were identified. EC as a trigger tool showed a PPV value of 0.38. Only 24 drugs have PA available in the market, which could avoid one third of all observed EC. Conclusion: It was possible to detect potentially HI in one of two patients with enteral feeding tubes using EC as a trigger tool. The use of EC as a trigger tool contributes to identifying potential HI arising from drugs, which have not gotten pharmaceutical alternatives to be administered via enteral feeding tube.Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Surgery and Anatomy School of Medicine University of São PauloPharmaceutical Assistance and Clinical Pharmacy Research Center Department of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP)Department of Clinical Toxicological and Bromatological Analyses School of Pharmaceutical Sciences of Ribeirão Preto University of São PauloDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Toma, Marina Massae [UNESP]Santana, Gabriel de Freitas [UNESP]de Nadai, Tales RubensVarallo, Fabiana RossiBenzi, Jhohann Richard de LimaMastroianni, Patrícia de Carvalho [UNESP]2023-03-01T20:59:16Z2023-03-01T20:59:16Z2022-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article183-192http://dx.doi.org/10.2174/1574886316666211014155946Current Drug Safety, v. 17, n. 3, p. 183-192, 2022.1574-8863http://hdl.handle.net/11449/24137510.2174/15748863166662110141559462-s2.0-85134567206Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCurrent Drug Safetyinfo:eu-repo/semantics/openAccess2024-06-24T13:46:12Zoai:repositorio.unesp.br:11449/241375Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:10:52.983559Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents |
title |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents |
spellingShingle |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents Toma, Marina Massae [UNESP] adverse drug event extemporaneous compounding medication therapy management Patient safety pharmacy service trigger tool |
title_short |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents |
title_full |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents |
title_fullStr |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents |
title_full_unstemmed |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents |
title_sort |
Extemporaneous Compounding: A Possible Trigger Tool to Detect Potential Health Incidents |
author |
Toma, Marina Massae [UNESP] |
author_facet |
Toma, Marina Massae [UNESP] Santana, Gabriel de Freitas [UNESP] de Nadai, Tales Rubens Varallo, Fabiana Rossi Benzi, Jhohann Richard de Lima Mastroianni, Patrícia de Carvalho [UNESP] |
author_role |
author |
author2 |
Santana, Gabriel de Freitas [UNESP] de Nadai, Tales Rubens Varallo, Fabiana Rossi Benzi, Jhohann Richard de Lima Mastroianni, Patrícia de Carvalho [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Toma, Marina Massae [UNESP] Santana, Gabriel de Freitas [UNESP] de Nadai, Tales Rubens Varallo, Fabiana Rossi Benzi, Jhohann Richard de Lima Mastroianni, Patrícia de Carvalho [UNESP] |
dc.subject.por.fl_str_mv |
adverse drug event extemporaneous compounding medication therapy management Patient safety pharmacy service trigger tool |
topic |
adverse drug event extemporaneous compounding medication therapy management Patient safety pharmacy service trigger tool |
description |
Background: Extemporaneous compounding (EC) involves the preparation of a therapeutic product for specific patient need. However, there is a potential relationship between this procedure and the occurrence of health incidents (HI). The use of trigger tools increases HI identification. Objective: This study assessed the performance of EC as a trigger to detect potential health incidents arising from this procedure. Methods: A one-month observational and cross-sectional study was performed in internal medicine ward and intensive care unit of medium-sized hospital. Data collection was carried out in 5 stages: all triggered patients with dysphagia or enteral feeding tube with prescription of EC were included; EC executed in prescribed standardized drugs was observed; the procedure was compared with the hospital guide and scientific literature; HI monitoring and their evaluation using WHO and NCC MERP algorithms; a search for pharmaceutical alternatives (PA) that would avoid the observed EC. Results: 197 patients were recruited. Almost half of them were triggered by EC from 84 standardized drugs. 48 patients met the inclusion criteria. 28 adverse drug reactions, 01 therapeutic ineffectiveness, and 29 medication errors were identified. EC as a trigger tool showed a PPV value of 0.38. Only 24 drugs have PA available in the market, which could avoid one third of all observed EC. Conclusion: It was possible to detect potentially HI in one of two patients with enteral feeding tubes using EC as a trigger tool. The use of EC as a trigger tool contributes to identifying potential HI arising from drugs, which have not gotten pharmaceutical alternatives to be administered via enteral feeding tube. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-01 2023-03-01T20:59:16Z 2023-03-01T20:59:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2174/1574886316666211014155946 Current Drug Safety, v. 17, n. 3, p. 183-192, 2022. 1574-8863 http://hdl.handle.net/11449/241375 10.2174/1574886316666211014155946 2-s2.0-85134567206 |
url |
http://dx.doi.org/10.2174/1574886316666211014155946 http://hdl.handle.net/11449/241375 |
identifier_str_mv |
Current Drug Safety, v. 17, n. 3, p. 183-192, 2022. 1574-8863 10.2174/1574886316666211014155946 2-s2.0-85134567206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Current Drug Safety |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
183-192 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129295386673152 |