Fructose: Toxic effect on cardiorenal risk factors and redox state

Detalhes bibliográficos
Autor(a) principal: Francisqueti, Fabiane V. [UNESP]
Data de Publicação: 2016
Outros Autores: Santos, Klinsmann C. [UNESP], Ferron, Artur J. T. [UNESP], Lo, Angelo T. C. [UNESP], Minatel, Igor O. [UNESP], Campos, Dijon H. S. [UNESP], Ferreira, Ana Lucia A. [UNESP], Correa, Camila R. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1177/2050312116684294
http://hdl.handle.net/11449/183979
Resumo: Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.
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spelling Fructose: Toxic effect on cardiorenal risk factors and redox stateAntioxidant imbalanceobesityblood pressureAim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)State Univ Unesp, Med Sch, BR-18618000 Botucatu, SP, BrazilState Univ Unesp, Inst Biosci, Botucatu, SP, BrazilState Univ Unesp, Med Sch, BR-18618000 Botucatu, SP, BrazilState Univ Unesp, Inst Biosci, Botucatu, SP, BrazilFAPESP: 2015/10626-0Sage Publications IncUniversidade Estadual Paulista (Unesp)Francisqueti, Fabiane V. [UNESP]Santos, Klinsmann C. [UNESP]Ferron, Artur J. T. [UNESP]Lo, Angelo T. C. [UNESP]Minatel, Igor O. [UNESP]Campos, Dijon H. S. [UNESP]Ferreira, Ana Lucia A. [UNESP]Correa, Camila R. [UNESP]2019-10-03T18:18:48Z2019-10-03T18:18:48Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6http://dx.doi.org/10.1177/2050312116684294Sage Open Medicine. Thousand Oaks: Sage Publications Inc, v. 4, 6 p., 2016.2050-3121http://hdl.handle.net/11449/18397910.1177/2050312116684294WOS:000443437900099Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSage Open Medicineinfo:eu-repo/semantics/openAccess2021-10-23T00:00:08Zoai:repositorio.unesp.br:11449/183979Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:42:18.894024Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Fructose: Toxic effect on cardiorenal risk factors and redox state
title Fructose: Toxic effect on cardiorenal risk factors and redox state
spellingShingle Fructose: Toxic effect on cardiorenal risk factors and redox state
Francisqueti, Fabiane V. [UNESP]
Antioxidant imbalance
obesity
blood pressure
title_short Fructose: Toxic effect on cardiorenal risk factors and redox state
title_full Fructose: Toxic effect on cardiorenal risk factors and redox state
title_fullStr Fructose: Toxic effect on cardiorenal risk factors and redox state
title_full_unstemmed Fructose: Toxic effect on cardiorenal risk factors and redox state
title_sort Fructose: Toxic effect on cardiorenal risk factors and redox state
author Francisqueti, Fabiane V. [UNESP]
author_facet Francisqueti, Fabiane V. [UNESP]
Santos, Klinsmann C. [UNESP]
Ferron, Artur J. T. [UNESP]
Lo, Angelo T. C. [UNESP]
Minatel, Igor O. [UNESP]
Campos, Dijon H. S. [UNESP]
Ferreira, Ana Lucia A. [UNESP]
Correa, Camila R. [UNESP]
author_role author
author2 Santos, Klinsmann C. [UNESP]
Ferron, Artur J. T. [UNESP]
Lo, Angelo T. C. [UNESP]
Minatel, Igor O. [UNESP]
Campos, Dijon H. S. [UNESP]
Ferreira, Ana Lucia A. [UNESP]
Correa, Camila R. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Francisqueti, Fabiane V. [UNESP]
Santos, Klinsmann C. [UNESP]
Ferron, Artur J. T. [UNESP]
Lo, Angelo T. C. [UNESP]
Minatel, Igor O. [UNESP]
Campos, Dijon H. S. [UNESP]
Ferreira, Ana Lucia A. [UNESP]
Correa, Camila R. [UNESP]
dc.subject.por.fl_str_mv Antioxidant imbalance
obesity
blood pressure
topic Antioxidant imbalance
obesity
blood pressure
description Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
2019-10-03T18:18:48Z
2019-10-03T18:18:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1177/2050312116684294
Sage Open Medicine. Thousand Oaks: Sage Publications Inc, v. 4, 6 p., 2016.
2050-3121
http://hdl.handle.net/11449/183979
10.1177/2050312116684294
WOS:000443437900099
url http://dx.doi.org/10.1177/2050312116684294
http://hdl.handle.net/11449/183979
identifier_str_mv Sage Open Medicine. Thousand Oaks: Sage Publications Inc, v. 4, 6 p., 2016.
2050-3121
10.1177/2050312116684294
WOS:000443437900099
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sage Open Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6
dc.publisher.none.fl_str_mv Sage Publications Inc
publisher.none.fl_str_mv Sage Publications Inc
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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