Fructose: Toxic effect on cardiorenal risk factors and redox state
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1177/2050312116684294 http://hdl.handle.net/11449/183979 |
Resumo: | Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure. |
id |
UNSP_3a60a27291fa38ed3df5bc2ee29886d3 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/183979 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Fructose: Toxic effect on cardiorenal risk factors and redox stateAntioxidant imbalanceobesityblood pressureAim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)State Univ Unesp, Med Sch, BR-18618000 Botucatu, SP, BrazilState Univ Unesp, Inst Biosci, Botucatu, SP, BrazilState Univ Unesp, Med Sch, BR-18618000 Botucatu, SP, BrazilState Univ Unesp, Inst Biosci, Botucatu, SP, BrazilFAPESP: 2015/10626-0Sage Publications IncUniversidade Estadual Paulista (Unesp)Francisqueti, Fabiane V. [UNESP]Santos, Klinsmann C. [UNESP]Ferron, Artur J. T. [UNESP]Lo, Angelo T. C. [UNESP]Minatel, Igor O. [UNESP]Campos, Dijon H. S. [UNESP]Ferreira, Ana Lucia A. [UNESP]Correa, Camila R. [UNESP]2019-10-03T18:18:48Z2019-10-03T18:18:48Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6http://dx.doi.org/10.1177/2050312116684294Sage Open Medicine. Thousand Oaks: Sage Publications Inc, v. 4, 6 p., 2016.2050-3121http://hdl.handle.net/11449/18397910.1177/2050312116684294WOS:000443437900099Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSage Open Medicineinfo:eu-repo/semantics/openAccess2021-10-23T00:00:08Zoai:repositorio.unesp.br:11449/183979Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:42:18.894024Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Fructose: Toxic effect on cardiorenal risk factors and redox state |
title |
Fructose: Toxic effect on cardiorenal risk factors and redox state |
spellingShingle |
Fructose: Toxic effect on cardiorenal risk factors and redox state Francisqueti, Fabiane V. [UNESP] Antioxidant imbalance obesity blood pressure |
title_short |
Fructose: Toxic effect on cardiorenal risk factors and redox state |
title_full |
Fructose: Toxic effect on cardiorenal risk factors and redox state |
title_fullStr |
Fructose: Toxic effect on cardiorenal risk factors and redox state |
title_full_unstemmed |
Fructose: Toxic effect on cardiorenal risk factors and redox state |
title_sort |
Fructose: Toxic effect on cardiorenal risk factors and redox state |
author |
Francisqueti, Fabiane V. [UNESP] |
author_facet |
Francisqueti, Fabiane V. [UNESP] Santos, Klinsmann C. [UNESP] Ferron, Artur J. T. [UNESP] Lo, Angelo T. C. [UNESP] Minatel, Igor O. [UNESP] Campos, Dijon H. S. [UNESP] Ferreira, Ana Lucia A. [UNESP] Correa, Camila R. [UNESP] |
author_role |
author |
author2 |
Santos, Klinsmann C. [UNESP] Ferron, Artur J. T. [UNESP] Lo, Angelo T. C. [UNESP] Minatel, Igor O. [UNESP] Campos, Dijon H. S. [UNESP] Ferreira, Ana Lucia A. [UNESP] Correa, Camila R. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Francisqueti, Fabiane V. [UNESP] Santos, Klinsmann C. [UNESP] Ferron, Artur J. T. [UNESP] Lo, Angelo T. C. [UNESP] Minatel, Igor O. [UNESP] Campos, Dijon H. S. [UNESP] Ferreira, Ana Lucia A. [UNESP] Correa, Camila R. [UNESP] |
dc.subject.por.fl_str_mv |
Antioxidant imbalance obesity blood pressure |
topic |
Antioxidant imbalance obesity blood pressure |
description |
Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2019-10-03T18:18:48Z 2019-10-03T18:18:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1177/2050312116684294 Sage Open Medicine. Thousand Oaks: Sage Publications Inc, v. 4, 6 p., 2016. 2050-3121 http://hdl.handle.net/11449/183979 10.1177/2050312116684294 WOS:000443437900099 |
url |
http://dx.doi.org/10.1177/2050312116684294 http://hdl.handle.net/11449/183979 |
identifier_str_mv |
Sage Open Medicine. Thousand Oaks: Sage Publications Inc, v. 4, 6 p., 2016. 2050-3121 10.1177/2050312116684294 WOS:000443437900099 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sage Open Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 |
dc.publisher.none.fl_str_mv |
Sage Publications Inc |
publisher.none.fl_str_mv |
Sage Publications Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129236486062080 |