Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/nu9121299 http://hdl.handle.net/11449/179412 |
Resumo: | Background: The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as diabetes, and cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflammatory and anti-oxidant properties, such as gamma-oryzanol (γQz) present mainly in bran layers and rice germ. Methods: Animals were randomly divided into four experimental groups and fed ad libitum for 20 weeks with control diet (C, n = 8), control diet + γOz (C + yOz, n = 8), high-sugar and high-fat diet (HSF, n = 8), and high-sugar and high-fat diet + γOz (HSF + γOz, n = 8). HSF groups also received water + sucrose (25%). The dose of γOz was added to diets to reach 0.5% of final concentration (w/w). Evaluation in animals included food and caloric intake, body weight, plasma glucose, insulin, triglycerides, uric acid, HOMA-IR, glomerular filtration rate, protein/creatinine ratio, systolic blood pressure, and Doppler echocardiographic. Results: Animals that consumed the HSF diet had weight gain compared to group C, increased insulin, HOMA, glucose and triglycerides, there were also atrial and ventricular structural alterations, deterioration of systolic and diastolic function, decreased glomerular filtration rate, and proteinuria. Gamma-oryzanol is significantly protective against effects on body weight, hypertriglyceridemia, renal damage, and against structural and functional alteration of the heart. Conclusion: Gamma-oryzanol shows potential as a therapeutic to prevent Cardiorenal Metabolic Syndrome. |
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Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat dietCardiac dysfunctionCardiorenal Metabolic SyndromeGamma-oryzanolHigh sugar-fat dietObesityRenal diseaseBackground: The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as diabetes, and cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflammatory and anti-oxidant properties, such as gamma-oryzanol (γQz) present mainly in bran layers and rice germ. Methods: Animals were randomly divided into four experimental groups and fed ad libitum for 20 weeks with control diet (C, n = 8), control diet + γOz (C + yOz, n = 8), high-sugar and high-fat diet (HSF, n = 8), and high-sugar and high-fat diet + γOz (HSF + γOz, n = 8). HSF groups also received water + sucrose (25%). The dose of γOz was added to diets to reach 0.5% of final concentration (w/w). Evaluation in animals included food and caloric intake, body weight, plasma glucose, insulin, triglycerides, uric acid, HOMA-IR, glomerular filtration rate, protein/creatinine ratio, systolic blood pressure, and Doppler echocardiographic. Results: Animals that consumed the HSF diet had weight gain compared to group C, increased insulin, HOMA, glucose and triglycerides, there were also atrial and ventricular structural alterations, deterioration of systolic and diastolic function, decreased glomerular filtration rate, and proteinuria. Gamma-oryzanol is significantly protective against effects on body weight, hypertriglyceridemia, renal damage, and against structural and functional alteration of the heart. Conclusion: Gamma-oryzanol shows potential as a therapeutic to prevent Cardiorenal Metabolic Syndrome.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (Unesp) Medical SchoolSão Paulo State University (Unesp) Institute of BiosciencesSão Paulo State University (Unesp) Medical SchoolSão Paulo State University (Unesp) Institute of BiosciencesFAPESP: 2015/10626-0Universidade Estadual Paulista (Unesp)Francisqueti, Fabiane Valentini [UNESP]Minatel, Igor Otávio [UNESP]Ferron, Artur Junio Togneri [UNESP]Bazan, Silméia Garcia Zanati [UNESP]Silva, Vanessa dos Santos [UNESP]Garcia, Jéssica Leite [UNESP]de Campos, Dijon Henrique Salomé [UNESP]Ferreira, Ana Lúcia [UNESP]Moreto, Fernando [UNESP]Cicogna, Antonio Carlos [UNESP]Corrêa, Camila Renata [UNESP]2018-12-11T17:35:05Z2018-12-11T17:35:05Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.3390/nu9121299Nutrients, v. 9, n. 12, 2017.2072-6643http://hdl.handle.net/11449/17941210.3390/nu91212992-s2.0-850370454302-s2.0-85037045430.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrients1,557info:eu-repo/semantics/openAccess2023-10-30T06:08:52Zoai:repositorio.unesp.br:11449/179412Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-30T06:08:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet |
title |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet |
spellingShingle |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet Francisqueti, Fabiane Valentini [UNESP] Cardiac dysfunction Cardiorenal Metabolic Syndrome Gamma-oryzanol High sugar-fat diet Obesity Renal disease |
title_short |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet |
title_full |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet |
title_fullStr |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet |
title_full_unstemmed |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet |
title_sort |
Effect of gamma-oryzanol as therapeutic agent to prevent cardiorenal metabolic syndrome in animals submitted to high sugar-fat diet |
author |
Francisqueti, Fabiane Valentini [UNESP] |
author_facet |
Francisqueti, Fabiane Valentini [UNESP] Minatel, Igor Otávio [UNESP] Ferron, Artur Junio Togneri [UNESP] Bazan, Silméia Garcia Zanati [UNESP] Silva, Vanessa dos Santos [UNESP] Garcia, Jéssica Leite [UNESP] de Campos, Dijon Henrique Salomé [UNESP] Ferreira, Ana Lúcia [UNESP] Moreto, Fernando [UNESP] Cicogna, Antonio Carlos [UNESP] Corrêa, Camila Renata [UNESP] |
author_role |
author |
author2 |
Minatel, Igor Otávio [UNESP] Ferron, Artur Junio Togneri [UNESP] Bazan, Silméia Garcia Zanati [UNESP] Silva, Vanessa dos Santos [UNESP] Garcia, Jéssica Leite [UNESP] de Campos, Dijon Henrique Salomé [UNESP] Ferreira, Ana Lúcia [UNESP] Moreto, Fernando [UNESP] Cicogna, Antonio Carlos [UNESP] Corrêa, Camila Renata [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Francisqueti, Fabiane Valentini [UNESP] Minatel, Igor Otávio [UNESP] Ferron, Artur Junio Togneri [UNESP] Bazan, Silméia Garcia Zanati [UNESP] Silva, Vanessa dos Santos [UNESP] Garcia, Jéssica Leite [UNESP] de Campos, Dijon Henrique Salomé [UNESP] Ferreira, Ana Lúcia [UNESP] Moreto, Fernando [UNESP] Cicogna, Antonio Carlos [UNESP] Corrêa, Camila Renata [UNESP] |
dc.subject.por.fl_str_mv |
Cardiac dysfunction Cardiorenal Metabolic Syndrome Gamma-oryzanol High sugar-fat diet Obesity Renal disease |
topic |
Cardiac dysfunction Cardiorenal Metabolic Syndrome Gamma-oryzanol High sugar-fat diet Obesity Renal disease |
description |
Background: The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as diabetes, and cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflammatory and anti-oxidant properties, such as gamma-oryzanol (γQz) present mainly in bran layers and rice germ. Methods: Animals were randomly divided into four experimental groups and fed ad libitum for 20 weeks with control diet (C, n = 8), control diet + γOz (C + yOz, n = 8), high-sugar and high-fat diet (HSF, n = 8), and high-sugar and high-fat diet + γOz (HSF + γOz, n = 8). HSF groups also received water + sucrose (25%). The dose of γOz was added to diets to reach 0.5% of final concentration (w/w). Evaluation in animals included food and caloric intake, body weight, plasma glucose, insulin, triglycerides, uric acid, HOMA-IR, glomerular filtration rate, protein/creatinine ratio, systolic blood pressure, and Doppler echocardiographic. Results: Animals that consumed the HSF diet had weight gain compared to group C, increased insulin, HOMA, glucose and triglycerides, there were also atrial and ventricular structural alterations, deterioration of systolic and diastolic function, decreased glomerular filtration rate, and proteinuria. Gamma-oryzanol is significantly protective against effects on body weight, hypertriglyceridemia, renal damage, and against structural and functional alteration of the heart. Conclusion: Gamma-oryzanol shows potential as a therapeutic to prevent Cardiorenal Metabolic Syndrome. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 2018-12-11T17:35:05Z 2018-12-11T17:35:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/nu9121299 Nutrients, v. 9, n. 12, 2017. 2072-6643 http://hdl.handle.net/11449/179412 10.3390/nu9121299 2-s2.0-85037045430 2-s2.0-85037045430.pdf |
url |
http://dx.doi.org/10.3390/nu9121299 http://hdl.handle.net/11449/179412 |
identifier_str_mv |
Nutrients, v. 9, n. 12, 2017. 2072-6643 10.3390/nu9121299 2-s2.0-85037045430 2-s2.0-85037045430.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrients 1,557 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964756330676224 |