Use of animals in dental research: Trends and ethical reflections

Detalhes bibliográficos
Autor(a) principal: Lopes, Camila Soares [UNESP]
Data de Publicação: 2022
Outros Autores: Fernandes, Clemente Maia S [UNESP], Barbosa, Aline Cristina S [UNESP], Serra, Mônica da Costa [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1177/00236772221115488
http://hdl.handle.net/11449/242148
Resumo: This study aimed to survey and analyze the profile of experimental dental research in animals, verifying its trends. We evaluated studies developed with the use of animals in vivo, published in 10 dental journals with high impact factors, from 2015 to 2020. From 1652 studies retrieved, 594 involved in vivo experimentation on animals and were analyzed further. Rats were the species most used and with the highest mean of animals per study. Ferrets, although presenting the lowest rate of publications, had the second highest mean of animals per study. Periodontics was the dental specialty with the highest number of publications, while oral rehabilitation had the lowest number. The data on the institution responsible for reviewing animal research protocols approval, sample size, anesthesia and analgesia were provided in 93.10%, 83%, 70.54% and 23.74% of studies, respectively. In 53% of studies, euthanasia was specified and anesthetic overdose was the method most used. Over the period analyzed, there was a reduction in animal studies in vivo, and periodontics was the specialty that most used this experimental model. Although most studies mentioned approval by an ethics committee, some publications neglected to mention sample size, anesthesia and euthanasia. The omission of essential information may raise scientific and ethical concerns.
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spelling Use of animals in dental research: Trends and ethical reflectionsAnimal experimentationanimal usebioethicsdental researchethicsThis study aimed to survey and analyze the profile of experimental dental research in animals, verifying its trends. We evaluated studies developed with the use of animals in vivo, published in 10 dental journals with high impact factors, from 2015 to 2020. From 1652 studies retrieved, 594 involved in vivo experimentation on animals and were analyzed further. Rats were the species most used and with the highest mean of animals per study. Ferrets, although presenting the lowest rate of publications, had the second highest mean of animals per study. Periodontics was the dental specialty with the highest number of publications, while oral rehabilitation had the lowest number. The data on the institution responsible for reviewing animal research protocols approval, sample size, anesthesia and analgesia were provided in 93.10%, 83%, 70.54% and 23.74% of studies, respectively. In 53% of studies, euthanasia was specified and anesthetic overdose was the method most used. Over the period analyzed, there was a reduction in animal studies in vivo, and periodontics was the specialty that most used this experimental model. Although most studies mentioned approval by an ethics committee, some publications neglected to mention sample size, anesthesia and euthanasia. The omission of essential information may raise scientific and ethical concerns.Department of Restorative Dentistry School of Dentistry São Paulo State University – UnespDepartment of Community Dentistry School of Dentistry São Paulo State University – UnespDepartment of Restorative Dentistry School of Dentistry São Paulo State University – UnespDepartment of Community Dentistry School of Dentistry São Paulo State University – UnespUniversidade Estadual Paulista (UNESP)Lopes, Camila Soares [UNESP]Fernandes, Clemente Maia S [UNESP]Barbosa, Aline Cristina S [UNESP]Serra, Mônica da Costa [UNESP]2023-03-02T10:07:06Z2023-03-02T10:07:06Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1177/00236772221115488Laboratory Animals.1758-11170023-6772http://hdl.handle.net/11449/24214810.1177/002367722211154882-s2.0-85135901858Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLaboratory Animalsinfo:eu-repo/semantics/openAccess2024-09-27T18:42:51Zoai:repositorio.unesp.br:11449/242148Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-27T18:42:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Use of animals in dental research: Trends and ethical reflections
title Use of animals in dental research: Trends and ethical reflections
spellingShingle Use of animals in dental research: Trends and ethical reflections
Lopes, Camila Soares [UNESP]
Animal experimentation
animal use
bioethics
dental research
ethics
title_short Use of animals in dental research: Trends and ethical reflections
title_full Use of animals in dental research: Trends and ethical reflections
title_fullStr Use of animals in dental research: Trends and ethical reflections
title_full_unstemmed Use of animals in dental research: Trends and ethical reflections
title_sort Use of animals in dental research: Trends and ethical reflections
author Lopes, Camila Soares [UNESP]
author_facet Lopes, Camila Soares [UNESP]
Fernandes, Clemente Maia S [UNESP]
Barbosa, Aline Cristina S [UNESP]
Serra, Mônica da Costa [UNESP]
author_role author
author2 Fernandes, Clemente Maia S [UNESP]
Barbosa, Aline Cristina S [UNESP]
Serra, Mônica da Costa [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Lopes, Camila Soares [UNESP]
Fernandes, Clemente Maia S [UNESP]
Barbosa, Aline Cristina S [UNESP]
Serra, Mônica da Costa [UNESP]
dc.subject.por.fl_str_mv Animal experimentation
animal use
bioethics
dental research
ethics
topic Animal experimentation
animal use
bioethics
dental research
ethics
description This study aimed to survey and analyze the profile of experimental dental research in animals, verifying its trends. We evaluated studies developed with the use of animals in vivo, published in 10 dental journals with high impact factors, from 2015 to 2020. From 1652 studies retrieved, 594 involved in vivo experimentation on animals and were analyzed further. Rats were the species most used and with the highest mean of animals per study. Ferrets, although presenting the lowest rate of publications, had the second highest mean of animals per study. Periodontics was the dental specialty with the highest number of publications, while oral rehabilitation had the lowest number. The data on the institution responsible for reviewing animal research protocols approval, sample size, anesthesia and analgesia were provided in 93.10%, 83%, 70.54% and 23.74% of studies, respectively. In 53% of studies, euthanasia was specified and anesthetic overdose was the method most used. Over the period analyzed, there was a reduction in animal studies in vivo, and periodontics was the specialty that most used this experimental model. Although most studies mentioned approval by an ethics committee, some publications neglected to mention sample size, anesthesia and euthanasia. The omission of essential information may raise scientific and ethical concerns.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-02T10:07:06Z
2023-03-02T10:07:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1177/00236772221115488
Laboratory Animals.
1758-1117
0023-6772
http://hdl.handle.net/11449/242148
10.1177/00236772221115488
2-s2.0-85135901858
url http://dx.doi.org/10.1177/00236772221115488
http://hdl.handle.net/11449/242148
identifier_str_mv Laboratory Animals.
1758-1117
0023-6772
10.1177/00236772221115488
2-s2.0-85135901858
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Laboratory Animals
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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