High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0205791 http://hdl.handle.net/11449/186189 |
Resumo: | Purpose High-intensity interval resistance training (HIIRT) is an increasingly popular exercise program that provides positive results with short sessions. This study aimed to evaluate whether an HIIRT session causes muscle and kidney damage. Methods Fifty-eight healthy volunteers (median age 24 years, 50% women) participated in this study and performed a HIIRT session. The Borg CR10 scale for pain (CR1OP) and blood and urine samples were collected before (baseline) and 2 and 24 hours after the HIIRT session. Blood samples were analyzed for serum creatinine (SCr), creatine kinase (CK) and myoglobin. Urine samples were assessed for creatinine, neutrophil gelatinase-associated lipocalin, interleukin 18, calbindin, microalbuminuria, trefoil factor-3 and beta-2 microglobulin. Results CR10P had a significant increase at 2 and 24 hours post-workout, and CK increased significantly at 2 hours and increased further at 24 hours. Myoglobin increased significantly at 2 hours and remained elevated at 24 hours. SCr increased modestly but significantly at 24 hours only in men. Three men met the KDIGO diagnostic criteria for acute kidney injury. The urinary kidney injury biomarkers increased significantly at 2 hours and returned to the baseline values 24 hours after HIIRT. Conclusions A single HIIRT session caused early and significant elevations in CK, myoglobin, SCr, microalbuminuria and urinary biomarkers indicative of kidney tubular injury, suggesting the occurrence of muscle and kidney damage. |
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High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individualsPurpose High-intensity interval resistance training (HIIRT) is an increasingly popular exercise program that provides positive results with short sessions. This study aimed to evaluate whether an HIIRT session causes muscle and kidney damage. Methods Fifty-eight healthy volunteers (median age 24 years, 50% women) participated in this study and performed a HIIRT session. The Borg CR10 scale for pain (CR1OP) and blood and urine samples were collected before (baseline) and 2 and 24 hours after the HIIRT session. Blood samples were analyzed for serum creatinine (SCr), creatine kinase (CK) and myoglobin. Urine samples were assessed for creatinine, neutrophil gelatinase-associated lipocalin, interleukin 18, calbindin, microalbuminuria, trefoil factor-3 and beta-2 microglobulin. Results CR10P had a significant increase at 2 and 24 hours post-workout, and CK increased significantly at 2 hours and increased further at 24 hours. Myoglobin increased significantly at 2 hours and remained elevated at 24 hours. SCr increased modestly but significantly at 24 hours only in men. Three men met the KDIGO diagnostic criteria for acute kidney injury. The urinary kidney injury biomarkers increased significantly at 2 hours and returned to the baseline values 24 hours after HIIRT. Conclusions A single HIIRT session caused early and significant elevations in CK, myoglobin, SCr, microalbuminuria and urinary biomarkers indicative of kidney tubular injury, suggesting the occurrence of muscle and kidney damage.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Med Sch, Div Nephrol, Sao Paulo, BrazilUniv Sao Paulo, Med Sch, LIM 12, Sao Paulo, BrazilHosp Clin Sao Paulo, Sao Paulo, BrazilSao Paulo State Univ, Sch Sci, Bauru, BrazilUniv Guarulhos, Div Sports, Guarulhos, BrazilUniv Sao Paulo, Med Sch, Hosp Clin, Dept Pathol,Clin Lab, Sao Paulo, BrazilUniv Sao Paulo, Med Sch, Hosp Clin, LIM 3, Sao Paulo, BrazilUniv Sao Paulo, Sch Publ Hlth, Sao Paulo, BrazilSao Paulo State Univ, Sch Sci, Bauru, BrazilCNPq: CNPq 133977/2015-3CNPq: CNPq 305858/2013-0FAPESP: FAPESP 2014/19286-4Public Library ScienceUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Univ GuarulhosSpada, Tania C.Silva, Jose M. R. D. [UNESP]Francisco, Lucila S.Marcal, Lia J.Antonangelo, LeilaZanetta, Dirce M. T.Yu, LuisBurdmann, Emmanuel A.2019-10-04T12:42:45Z2019-10-04T12:42:45Z2018-11-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13http://dx.doi.org/10.1371/journal.pone.0205791Plos One. San Francisco: Public Library Science, v. 13, n. 11, 13 p., 2018.1932-6203http://hdl.handle.net/11449/18618910.1371/journal.pone.0205791WOS:000449374000003Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlos Oneinfo:eu-repo/semantics/openAccess2021-10-23T12:23:55Zoai:repositorio.unesp.br:11449/186189Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:25:02.609210Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals |
title |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals |
spellingShingle |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals Spada, Tania C. |
title_short |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals |
title_full |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals |
title_fullStr |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals |
title_full_unstemmed |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals |
title_sort |
High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals |
author |
Spada, Tania C. |
author_facet |
Spada, Tania C. Silva, Jose M. R. D. [UNESP] Francisco, Lucila S. Marcal, Lia J. Antonangelo, Leila Zanetta, Dirce M. T. Yu, Luis Burdmann, Emmanuel A. |
author_role |
author |
author2 |
Silva, Jose M. R. D. [UNESP] Francisco, Lucila S. Marcal, Lia J. Antonangelo, Leila Zanetta, Dirce M. T. Yu, Luis Burdmann, Emmanuel A. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Univ Guarulhos |
dc.contributor.author.fl_str_mv |
Spada, Tania C. Silva, Jose M. R. D. [UNESP] Francisco, Lucila S. Marcal, Lia J. Antonangelo, Leila Zanetta, Dirce M. T. Yu, Luis Burdmann, Emmanuel A. |
description |
Purpose High-intensity interval resistance training (HIIRT) is an increasingly popular exercise program that provides positive results with short sessions. This study aimed to evaluate whether an HIIRT session causes muscle and kidney damage. Methods Fifty-eight healthy volunteers (median age 24 years, 50% women) participated in this study and performed a HIIRT session. The Borg CR10 scale for pain (CR1OP) and blood and urine samples were collected before (baseline) and 2 and 24 hours after the HIIRT session. Blood samples were analyzed for serum creatinine (SCr), creatine kinase (CK) and myoglobin. Urine samples were assessed for creatinine, neutrophil gelatinase-associated lipocalin, interleukin 18, calbindin, microalbuminuria, trefoil factor-3 and beta-2 microglobulin. Results CR10P had a significant increase at 2 and 24 hours post-workout, and CK increased significantly at 2 hours and increased further at 24 hours. Myoglobin increased significantly at 2 hours and remained elevated at 24 hours. SCr increased modestly but significantly at 24 hours only in men. Three men met the KDIGO diagnostic criteria for acute kidney injury. The urinary kidney injury biomarkers increased significantly at 2 hours and returned to the baseline values 24 hours after HIIRT. Conclusions A single HIIRT session caused early and significant elevations in CK, myoglobin, SCr, microalbuminuria and urinary biomarkers indicative of kidney tubular injury, suggesting the occurrence of muscle and kidney damage. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-06 2019-10-04T12:42:45Z 2019-10-04T12:42:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0205791 Plos One. San Francisco: Public Library Science, v. 13, n. 11, 13 p., 2018. 1932-6203 http://hdl.handle.net/11449/186189 10.1371/journal.pone.0205791 WOS:000449374000003 |
url |
http://dx.doi.org/10.1371/journal.pone.0205791 http://hdl.handle.net/11449/186189 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 13, n. 11, 13 p., 2018. 1932-6203 10.1371/journal.pone.0205791 WOS:000449374000003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plos One |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
13 |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128358273253376 |