Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)

Detalhes bibliográficos
Autor(a) principal: Negri, K. M.S. [UNESP]
Data de Publicação: 2017
Outros Autores: Malafronte, N., Certo, G., D’Angelo, V., Rapisarda, A., Bauab, T. M. [UNESP], Germanò, M. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/220857
Resumo: Astronium urundeuva (Fr. All.) Engl. (aroeira-do-sertão) (Anacardiaceae) is an arboreal species typical of northeast brazilian savanna popularly used for its anti-inflammatory, antimicrobial, anti-ulcerogenic and healing properties. In this study the effects of A. urundeuva on in vivo angiogenesis are evaluated. Stem bark (AUS) and leaves (AUL) extracts (EtOH 70%) are investigated on zebrafish embryos and chick chorioallantoic membrane (CAM). Results of the biological screening show that AUS extracts induce a weak anti-angiogenic response in both experimental models. Conversely, AUL extracts at 25 and 50 μg/mL enhance vessel formation in zebrafish embryos submitted to the endogenous alkaline phosphatase (EAP) assay. Moreover, an increased blood vessel development and an higher level of total hemoglobin content is observed in the CAMs exposed to AUL at 80 μg/egg as compared to control. The proangiogenic effects of AUL in two in vivo models suggest its potential use as a source of new therapeutic agents able to modulate angiogenesis.
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spelling Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)AngiogenesisAstronium urundeuvaChick chorioallantoic membraneEndogenous alkaline phosphatase stainingHaemoglobinZebrafishAstronium urundeuva (Fr. All.) Engl. (aroeira-do-sertão) (Anacardiaceae) is an arboreal species typical of northeast brazilian savanna popularly used for its anti-inflammatory, antimicrobial, anti-ulcerogenic and healing properties. In this study the effects of A. urundeuva on in vivo angiogenesis are evaluated. Stem bark (AUS) and leaves (AUL) extracts (EtOH 70%) are investigated on zebrafish embryos and chick chorioallantoic membrane (CAM). Results of the biological screening show that AUS extracts induce a weak anti-angiogenic response in both experimental models. Conversely, AUL extracts at 25 and 50 μg/mL enhance vessel formation in zebrafish embryos submitted to the endogenous alkaline phosphatase (EAP) assay. Moreover, an increased blood vessel development and an higher level of total hemoglobin content is observed in the CAMs exposed to AUL at 80 μg/egg as compared to control. The proangiogenic effects of AUL in two in vivo models suggest its potential use as a source of new therapeutic agents able to modulate angiogenesis.Department of Biological Sciences Univ Estadual PaulistaDepartment of Pharmacy University of Salerno, Via Giovanni Paolo II 132Department of Chemical Biological Pharmaceutical and Environmental Sciences University of MessinaDepartment of Biological Sciences Univ Estadual PaulistaUniversidade Estadual Paulista (UNESP)University of SalernoUniversity of MessinaNegri, K. M.S. [UNESP]Malafronte, N.Certo, G.D’Angelo, V.Rapisarda, A.Bauab, T. M. [UNESP]Germanò, M. P.2022-04-28T19:06:20Z2022-04-28T19:06:20Z2017-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article46-54Pharmacologyonline, v. 1, p. 46-54.1827-8620http://hdl.handle.net/11449/2208572-s2.0-85019662654Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacologyonlineinfo:eu-repo/semantics/openAccess2022-04-28T19:06:20Zoai:repositorio.unesp.br:11449/220857Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:43:04.783531Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
title Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
spellingShingle Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
Negri, K. M.S. [UNESP]
Angiogenesis
Astronium urundeuva
Chick chorioallantoic membrane
Endogenous alkaline phosphatase staining
Haemoglobin
Zebrafish
title_short Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
title_full Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
title_fullStr Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
title_full_unstemmed Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
title_sort Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)
author Negri, K. M.S. [UNESP]
author_facet Negri, K. M.S. [UNESP]
Malafronte, N.
Certo, G.
D’Angelo, V.
Rapisarda, A.
Bauab, T. M. [UNESP]
Germanò, M. P.
author_role author
author2 Malafronte, N.
Certo, G.
D’Angelo, V.
Rapisarda, A.
Bauab, T. M. [UNESP]
Germanò, M. P.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
University of Salerno
University of Messina
dc.contributor.author.fl_str_mv Negri, K. M.S. [UNESP]
Malafronte, N.
Certo, G.
D’Angelo, V.
Rapisarda, A.
Bauab, T. M. [UNESP]
Germanò, M. P.
dc.subject.por.fl_str_mv Angiogenesis
Astronium urundeuva
Chick chorioallantoic membrane
Endogenous alkaline phosphatase staining
Haemoglobin
Zebrafish
topic Angiogenesis
Astronium urundeuva
Chick chorioallantoic membrane
Endogenous alkaline phosphatase staining
Haemoglobin
Zebrafish
description Astronium urundeuva (Fr. All.) Engl. (aroeira-do-sertão) (Anacardiaceae) is an arboreal species typical of northeast brazilian savanna popularly used for its anti-inflammatory, antimicrobial, anti-ulcerogenic and healing properties. In this study the effects of A. urundeuva on in vivo angiogenesis are evaluated. Stem bark (AUS) and leaves (AUL) extracts (EtOH 70%) are investigated on zebrafish embryos and chick chorioallantoic membrane (CAM). Results of the biological screening show that AUS extracts induce a weak anti-angiogenic response in both experimental models. Conversely, AUL extracts at 25 and 50 μg/mL enhance vessel formation in zebrafish embryos submitted to the endogenous alkaline phosphatase (EAP) assay. Moreover, an increased blood vessel development and an higher level of total hemoglobin content is observed in the CAMs exposed to AUL at 80 μg/egg as compared to control. The proangiogenic effects of AUL in two in vivo models suggest its potential use as a source of new therapeutic agents able to modulate angiogenesis.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-30
2022-04-28T19:06:20Z
2022-04-28T19:06:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Pharmacologyonline, v. 1, p. 46-54.
1827-8620
http://hdl.handle.net/11449/220857
2-s2.0-85019662654
identifier_str_mv Pharmacologyonline, v. 1, p. 46-54.
1827-8620
2-s2.0-85019662654
url http://hdl.handle.net/11449/220857
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmacologyonline
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 46-54
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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